Side Effects of simethicone: A Synthesis of Findings from 26 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Simethicone is a medication that is commonly used to treat gas and bloating. It works by reducing the surface tension of gas bubbles in the digestive tract, allowing them to coalesce and be more easily passed. While simethicone is generally considered safe, there have been some reports of side effects.

Reasons for Side Effects

The side effects of simethicone are likely due to its mechanism of action. By reducing the surface tension of gas bubbles, simethicone can also affect the normal function of the digestive system. For example, it may affect the amount of stomach acid produced or the movement of food through the digestive tract.

Common Side Effects

Constipation

In 7 , constipation was reported when simethicone was added to polyethylene glycol electrolyte solution.

Diarrhea

In 21 , diarrhea was reported when using an antacid containing simethicone.

Abdominal Bloating

In 8 , abdominal bloating was reported when simethicone was used as an adjunct to bowel preparation agents.

Side Effects Management

Constipation

If constipation occurs due to simethicone, it is important to increase fluid intake, eat foods high in fiber, and exercise regularly. If constipation persists, consult a doctor for possible medication.

Diarrhea

If diarrhea occurs due to simethicone, consider taking over-the-counter anti-diarrheal medication. However, always follow a doctor's instructions when taking any medication.

Abdominal Bloating

If abdominal bloating occurs due to simethicone, try reducing meal size, eating slowly, and avoiding foods that tend to cause bloating. Consult a doctor if bloating persists to rule out digestive issues.

Comparison Between Studies

Similarities Between Studies

Many studies have shown that simethicone is effective in treating various digestive symptoms. Additionally, simethicone is generally considered a safe medication with no reports of serious side effects. However, it's important to note that there is variability in the effectiveness and side effects of simethicone between individual studies.

Differences Between Studies

There can be differences in the effectiveness and severity of side effects of simethicone between studies, likely due to differences in study subjects, methods, and conditions. For example, 12 did not establish whether simethicone is effective in treating infantile colic. In contrast, 14 showed that simethicone is effective in preparing the intestines for capsule endoscopy. These findings suggest that the effectiveness of simethicone may vary depending on its application and the condition being treated.

Cautions on Real-Life Application

While simethicone is generally considered safe, side effects are possible. Before taking simethicone, consult a doctor to ensure it is appropriate for your health condition and body type. Additionally, if you experience any unusual symptoms while taking simethicone, consult a doctor immediately. It is especially important to consult a doctor before taking simethicone if you are pregnant or breastfeeding.

Limitations of Current Research

Research on the safety and effectiveness of simethicone is still ongoing and not completely conclusive. More research is needed, particularly on the long-term effects of using simethicone and its effectiveness for different diseases. Further investigation into interactions between simethicone and other medications is also necessary.

Future Research Directions

Further research on the safety and effectiveness of simethicone is crucial. This includes investigating long-term effects of using simethicone, its effectiveness in treating various conditions, and interactions with other medications. These studies will provide a comprehensive understanding of simethicone's benefits and risks.

Conclusion

Simethicone is a medication commonly used to treat gas and bloating. While generally safe, it can cause side effects. It is crucial to consult a doctor before taking simethicone to ensure its suitability for your health condition. If any unusual symptoms arise, immediately consult a doctor. Further research on simethicone's long-term effects, interactions with other medications, and effectiveness for different diseases is necessary for a thorough understanding of its benefits and risks.

Literature analysis of 26 papers
Positive Content
25
Neutral Content
1
Negative Content
0
Article Type
12
2
4
4
26
1.

Evaluation of side effects of sildenafil in group of young healthy volunteers.

Author: DündarM, KoçakI, DündarS O, ErolH

Treat erectile dysfunction
Arthralgia
Dyspepsia
Flushing
Headache
Palpitation

Sildenafil, a drug for erectile dysfunction, showed a statistically significant increase in heart rate and common side effects like flushing, headache, and dyspepsia in sexually active volunteers, even without sexual stimulation. While these side effects may be acceptable, potential users should be informed of their likelihood.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy.

Author: SteinDaniel J, CoplandAndrew, McDanielDeborah, HaysR Ann

Small bowel visualization
Recorder failure

Linaclotide, a single-dose given 1 hour before capsule endoscopy, was equally effective as polyethylene glycol (PEG) in improving visualization and transit time in patients undergoing small bowel capsule endoscopy. Both regimens were well-tolerated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease.

Author: RestelliniSophie, KheradOmar, BessissowTalat, MénardCharles, MartelMyriam, Taheri TanjaniMaryam, LakatosPeter L, BarkunAlan N

Improved bowel cleansing
Side effects

Low-volume polyethylene glycol (PEG) regimens were as effective as high-volume PEG regimens in cleansing the colon of patients with inflammatory bowel disease. Low-volume regimens were also associated with greater willingness to repeat the procedure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

[Comparative Study on Bowel Preparation Efficacy of Ascorbic Acid Containing Polyethylene Glycol by Adding Either Simethicone or 1 L of Water in Health Medical Examination Patients: A Prospective Randomized Controlled Study].

Author: YeoSe Hwan, KwakJae Hoon, KimYeo Un, KwonTae Ho, ParkJeong Bae, ParkJun Hyung, LeeYong Kook, LimYun Jeong, YangChang Heon

Bowel cleansing
Reduced bubble elimination
Side effects

This randomized controlled trial compared the efficacy of a polyethylene glycol with ascorbic acid (PEGA) bowel preparation regimen with the addition of simethicone or 1 L of water. PEGA alone demonstrated satisfactory bowel cleansing, while the addition of simethicone significantly reduced the amount of bubbles and increased patient satisfaction compared to the addition of water.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Korean

8.

Adjuncts to colonic cleansing before colonoscopy.

Author: ParkSanghoon, LimYun Jeong

Improved bowel cleansing
Drug interactions

This review examines the use of adjunctive agents to improve colonic cleansing effectiveness during colonoscopy preparation. While no single agent has completely overcome limitations of the gold standard method, several promising options, such as bisacodyl, magnesium citrate, senna, simethicone, metoclopramide, and prokinetics, can enhance the efficiency of traditional bowel preparation agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

[Efficacy of alverina citrate and simethicone combination in abdominal pain and discomfort of irritable bowel syndrome].

Author: WittmannT, ParadovskyL, DucrotteP, BuenoL, Andro-DelestrainM C T

Reduced abdominal pain

The combination of alverina citrate and simethicone was significantly more effective in patients with IBS compared to placebo in reducing abdominal pain or discomfort.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

11.

[Comparison of a new medical device with domperidone in functional dyspepsia: a randomized, cross-over, controlled study].

Author: GalloA, GiovinaleM, FonnesuC, CovinoM, MontaltoM, GasbarriniG

Symptomatic improvement
Side effects

A new medical device was evaluated for its efficacy in patients with functional dyspepsia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Italian

12.

Infantile colic: a systematic review of medical and conventional therapies.

Author: HallBelinda, ChestersJanice, RobinsonAnske

Reduced colic

There is some scientific evidence to support the use of a casein hydrolysate formula in formula-fed infants or a low-allergen maternal diet in breastfed infants with infantile colic. However, there is little scientific evidence to support the use of Simethicone, Dicyclomine hydrochloride, Cimetropium bromide, lactase, additional fiber, or behavioral interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation.

Author: TongprasertSasinee, SobhonslidsukAbhasnee, RattanasiriSasivimol

Colonoscopy visibility
Patient satisfaction

This study found that adding simethicone to sodium phosphate bowel preparation significantly improved colonoscopy visibility by diminishing air bubbles. Endoscopist and patient satisfaction were also increased, but there was no difference in the total duration of the procedure or side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Effect of small bowel preparation with simethicone on capsule endoscopy.

Author: FangYou-hong, ChenChun-xiao, ZhangBing-ling

Small bowel visualization

Capsule endoscopy is a new technology that allows doctors to examine the small intestine. This study examined the use of simethicone, an anti-gas medication, in bowel preparation before capsule endoscopy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Magnesium-aluminum hydroxide suspension for the treatment of dermal capsaicin exposures.

Author: LeeDavid C, RyanJames R

Cheap and readily available
Reduced pain
Minimal side effects

Magnesium-aluminum-hydroxide-simethicone suspension (MgAl) was found to significantly reduce pain scores during the first 30 minutes of treatment for dermal capsaicin exposure. Although the clinical significance of this difference is questionable, MgAl is a cheap and readily available treatment option with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effectiveness of treatments for infantile colic: systematic review.

Author: LucassenP L, AssendelftW J, GubbelsJ W, van EijkJ T, van GeldropW J, NevenA K

Colic relief
Reduced crying
Side effects

Hypoallergenic formula milk is effective in reducing crying in infants with infantile colic. Reducing stimulation and a one-week trial of hypoallergenic formula are recommended as first-line treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Small volume isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in treatment of chronic nonorganic constipation.

Author: CorazziariE, BadialiD, HabibF I, ReboaG, PittoG, MazzaccaG, SabbatiniF, GaleazziR, CilluffoT, VantiniI, BardelliE, BaldiF

Constipation treatment
Few side effects
Improved bowel function
Reduced laxative use

This study found that polyethylene glycol (PEG) solution, taken twice daily, was effective in increasing bowel frequency and improving constipation symptoms in patients with chronic nonorganic constipation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

[Management of infantile colics].

Author: SavinoF, OggeroR

Colic management

This article proposes a scoring system for evaluating infantile colic based on crying intensity, duration, and associated symptoms, and outlines a management plan based on the score.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Italian

20.

[Premedication for sonography. Enzyme-paractol in comparison with a placebo].

Author: HeyderN, LutzH, HorbachL

Improves ultrasonographic representation
Side effects

Enzym-Paractol improved the ultrasonographic representation of internal organs compared to placebo, with no difference in side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

21.

Open safety-in-use trial of a new high-potency antacid product.

Author: PawlowskiG J, KrondlA, DarkeA C

Antacid efficacy
Taste acceptability
Diarrhea

A new high-potency antacid product was effective in relieving 67% to 73% of upper gastro-intestinal tract symptoms in 109 patients. 70% of patients preferred the new product to previous antacid therapy. The incidence of product-related side-effects was low, with only 6.7% experiencing diarrhea or loose stools.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

A controlled trial of senna preparations and other laxatives used for bowel cleansing prior to radiological examination.

Author: BrouwersJ R, van OuwerkerkW P, de BoerS M, ThomanL

Improved palatability
Safe for diabetics
Cramps
Side effects

Standardized sennoside preparations are effective in treating constipation. HP is the most effective and safe, however, PP has fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Comparative study of cimetidine and Mylanta II in the 6-week treatment of gastric ulcer.

Author: SherbaniukR W, WenselR H, BaileyR J, KirdeikisP, FisherD, ThomsonA B

Gastric Ulcer Pain Relief

Cimetidine (300 mg q.i.d.) was more effective than antacids in healing gastric ulcers in 38 patients. Both treatments effectively relieved symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery.

Author: LamotheP H, RaoE, SerraA J, CastellanoJ, WoronickC L, McNicholasK W, LemoleG M

Postoperative stress ulceration prevention
Hematologic and neurological side effects

Famotidine and ranitidine were more effective than cimetidine in controlling gastric pH and preventing postoperative stress ulceration in patients undergoing coronary artery bypass.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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