Side Effects of sodium zirconium cyclosilicate: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Main Research Findings

Sodium zirconium cyclosilicate is a new medication used to treat hyperkalemia. This medication has been shown to have fewer side effects compared to the traditional treatment, sodium polystyrene sulfonate (SPS). 2

Sodium zirconium cyclosilicate has been shown to be effective in treating hyperkalemia in patients with chronic kidney disease (CKD). 5

Sodium zirconium cyclosilicate may be effective in treating hyperkalemia in patients with heart failure. 7

Sodium zirconium cyclosilicate has been shown to be effective in treating hyperkalemia. 6

Reasons for Side Effects

Sodium zirconium cyclosilicate works by binding to potassium in the intestines and eliminating it through the stool, thus improving hyperkalemia. However, this medication can also bind to sodium and calcium in the intestines, which may lead to side effects such as constipation and intestinal obstruction. 3

Common Side Effects

Constipation

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of constipation as a side effect. 3

Intestinal Obstruction

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of intestinal obstruction as a side effect. 3

Diarrhea

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of diarrhea as a side effect. 3

Abdominal Pain

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of abdominal pain as a side effect. 3

Vomiting

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of vomiting as a side effect. 3

Maldigestion

Sodium zirconium cyclosilicate binds to potassium in the intestines and eliminates it through stool, leading to the possibility of maldigestion as a side effect. 3

Side Effect Countermeasures

Constipation Countermeasures

To prevent constipation, it is essential to drink plenty of fluids. Increasing intake of foods rich in dietary fiber is also effective. 3

Intestinal Obstruction Countermeasures

If symptoms of intestinal obstruction are suspected, seek medical attention immediately. 3

Diarrhea Countermeasures

If diarrhea persists, seek medical attention. 3

Abdominal Pain Countermeasures

If you experience severe abdominal pain, seek medical attention. 3

Vomiting Countermeasures

If you experience persistent vomiting, seek medical attention. 3

Maldigestion Countermeasures

If you experience persistent maldigestion, seek medical attention. 3

Comparison between Studies

Commonalities among Studies

These studies indicate that sodium zirconium cyclosilicate is effective in treating hyperkalemia. 5 7 6 3 2

Differences among Studies

These studies indicate that side effects of sodium zirconium cyclosilicate vary. 5 7 6 3 2

Cautions Regarding Real-Life Applications

While sodium zirconium cyclosilicate has been shown to be effective in treating hyperkalemia, it is important to remember that there is a risk of side effects. 5 7 6 3 2

Limitations of Current Research

There is still insufficient data on the long-term safety and efficacy of sodium zirconium cyclosilicate. 5 7 6 3 2

Future Research Directions

Research is needed to evaluate the long-term safety and efficacy of sodium zirconium cyclosilicate. 5 7 6 3 2

Conclusion

Sodium zirconium cyclosilicate is a new medication that has been shown to be effective in treating hyperkalemia. However, it is important to remember that there is a risk of side effects. If you are considering using sodium zirconium cyclosilicate, it is essential to consult with your doctor. 5 7 6 3 2

Literature analysis of 9 papers
Positive Content
8
Neutral Content
0
Negative Content
1
Article Type
1
2
2
5
9
1.

Risk of Intestinal Necrosis With Sodium Polystyrene Sulfonate: A Systematic Review and Meta-analysis.

Author: HolleckJürgen L, RobertsAndrea E, MarhofferElizabeth A, GrimshawAlyssa A, GundersonCraig G

Intestinal necrosis

This systematic review examines the gastrointestinal side effects of sodium polystyrene sulfonate (SPS), particularly intestinal necrosis. The review included studies with controls and reported the rates of intestinal necrosis associated with SPS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Radiopacity of sodium zirconium cyclosilicate on CT imaging.

Author: KolesnikMichael, BerezovskyDavid, SayeghMartin, SamarnehMajed

Hyperkalemia treatment

Sodium zirconium cyclosilicate, a medication for hyperkalemia, was found to be radiopaque on CT imaging. This finding highlights the importance of understanding the differential of radiopaque substances in imaging.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.

Author: NatalePatrizia, PalmerSuetonia C, RuospoMarinella, SaglimbeneValeria M, StrippoliGiovanni Fm

CKD management
Hyperkalemia treatment
GI side effects

Hyperkalemia is a condition characterized by high potassium levels in the blood, often seen in people with kidney disease. This review discusses the different types of potassium-binding medications available for treating hyperkalemia, including newer options like patiromer and sodium zirconium cyclosilicate. The review aims to provide guidance on the effectiveness and tolerability of these medications for individuals with kidney disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

[Management of hyperkalemia in Nephrology and Cardiology clinics: reality and perspectives].

Author: De NicolaLuca, GarofaloCarlo, ProvenzanoMichele, GrossetoDaniele, MagnaniGiulia, PulignanoGiovanni

Cardiovascular event reduction
End-stage renal disease reduction
Mortality reduction
Hyperkalemia

This review examines the shared aspects of chronic kidney disease (CKD) and chronic heart failure (CHF), emphasizing the role of renin-angiotensin-aldosterone system inhibitors (RAASI) in managing both conditions. It also discusses the challenges of hyperkalemia induced by RAASI and explores new drug options for its management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

5.

[Hyperkalemia treatment in chronic kidney disease patients: overview on new K binders and possible therapeutic approaches].

Author: De StefanoToni, BorrelliSilvio, GarofaloCarlo, ProvenzanoMichele, De NicolaLuca, MinutoloRoberto, ConteGiuseppe

Hyperkalaemia treatment
CKD
Hyperkalaemia

High potassium levels are common in people with chronic kidney disease (CKD) and can cause weakness, paralysis, heart problems, and death. New medications like Patiromer and ZS-9 are more effective than older treatments for high potassium levels, with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

7.

Role of Hyperkalemia in Heart Failure and the Therapeutic Use of Potassium Binders.

Author: SarwarChaudhry M S, BhagatAditi A, AnkerStefan D, ButlerJaved

Treats Hyperkalemia
Side Effects

This chapter reviews the pathophysiology of hyperkalemia and discusses the use of novel potassium-lowering compounds, patiromersorbitex calcium and sodium zirconium cyclosilicate, for the treatment and prevention of hyperkalemia in at-risk populations, particularly those with heart failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A randomized study to compare oral potassium binders in the treatment of acute hyperkalemia.

Author: CañasAlejandro E, TrouttHayden R, JiangLuohua, TonthatSam, DarwishOmar, FerreyAntoney, LotfipourShahram, Kalantar-ZadehKamyar, HannaRamy, LauWei Ling

Potassium binder
Hyperkalemia

This study aims to compare the effectiveness of oral potassium binders versus a nonspecific laxative in the treatment of acute hyperkalemia. The study will investigate the change in potassium levels, length of hospital stay, and gastrointestinal side effects.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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