Key Research Findings

Solriamfetol is a novel wake-promoting agent that has been approved for the treatment of excessive daytime sleepiness (EDS) associated with narcolepsy or obstructive sleep apnea (OSA). 1 Studies have shown that solriamfetol is effective in reducing sleepiness and improving wakefulness in patients with narcolepsy or OSA. 1 Solriamfetol is believed to work by selectively inhibiting the reuptake of dopamine and norepinephrine, which are neurotransmitters involved in alertness and wakefulness. 1

Reasons for Side Effects

Solriamfetol exerts its wake-promoting effects by inhibiting the reuptake of dopamine and norepinephrine. However, this action can also impact other neurotransmitters, potentially leading to side effects. 1

Common Side Effects

Headache

Headache is a common side effect of solriamfetol. This could be due to the alteration of neurotransmitter balance caused by the inhibition of dopamine and norepinephrine reuptake. 1

Nausea

Nausea can occur with solriamfetol. The inhibition of dopamine and norepinephrine reuptake might disrupt the balance of neurotransmitters in the gastrointestinal system, potentially leading to nausea. 1

Dry Mouth

Dry mouth is another possible side effect of solriamfetol. The inhibition of dopamine and norepinephrine reuptake could reduce saliva production, resulting in dry mouth. 1

Insomnia

Solriamfetol can cause insomnia. The prolonged wakefulness induced by inhibiting dopamine and norepinephrine reuptake may interfere with sleep patterns. 1

Anxiety

Anxiety is a potential side effect of solriamfetol. The altered neurotransmitter balance due to the inhibition of dopamine and norepinephrine reuptake could contribute to anxiety. 1

Side Effect Management

Headache

Over-the-counter pain relievers and rest can often alleviate headaches. 1

Nausea

Eating small, frequent meals and staying hydrated can help mitigate nausea. 1

Dry Mouth

Drinking plenty of fluids is essential to combat dry mouth. 1

Insomnia

If insomnia occurs, consult a healthcare professional for appropriate treatment. 1

Anxiety

If anxiety develops, seek medical advice and appropriate treatment. 1

Research Comparison

Commonalities

Both papers indicate that solriamfetol is a promising treatment option for excessive daytime sleepiness associated with narcolepsy or OSA. 2 1

Differences

2 provides a broader perspective on the potential of solriamfetol in managing narcolepsy, while 1 focuses on the clinical applications of solriamfetol. Notably, 1 emphasizes the role of solriamfetol in patient selection and treatment strategies.

Real-Life Application Considerations

Solriamfetol has demonstrated effectiveness in alleviating excessive daytime sleepiness associated with narcolepsy or OSA. However, it is crucial to consider the potential side effects. 1

Specifically, solriamfetol's wake-promoting action through dopamine and norepinephrine reuptake inhibition can potentially impact other neurotransmitters. 1

Therefore, when considering solriamfetol, it is essential to consult with a healthcare professional, understand the risks and benefits, and follow prescribed dosage instructions. 1

Current Research Limitations

Research on the long-term safety and efficacy of solriamfetol is still limited. 1 Additionally, more effective strategies for managing solriamfetol-related side effects are needed. 1

Future Research Directions

Further investigations into the long-term safety and efficacy of solriamfetol are necessary. 1 Research on the prevention and treatment of solriamfetol-induced side effects is also crucial. 1

Conclusion

Solriamfetol is a promising treatment option for excessive daytime sleepiness associated with narcolepsy or OSA, as supported by research. 1 However, it is essential to be aware of the potential side effects. 1

Before considering solriamfetol, consult with a healthcare professional to understand the risks and benefits and ensure proper dosage instructions are followed. 1