Effects of spinosad topical: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown that spinosad is a promising insecticide that can be effective for a variety of applications in humans and animals. 1 investigated the side effects of co-administration of spinosad and sildenafil in healthy men and found no significant side effects. In addition, 8 demonstrated that spinosad is effective in treating flea infestations in cats and was shown to be more effective than the traditional treatment, selamectin. Furthermore, 5 revealed that while spinosad exhibits some toxicity to bees, it is safer than other insecticides. 7 showed that spinosad is effective in controlling medfly, and it was found to be more effective than chlorpyrifos, a traditionally used insecticide for medfly control. demonstrated that spinosad is effective against golf course pests that have developed resistance to pyrethroid insecticides. 4 showed that spinosad exhibits some toxicity to stingless bees, but it is safer than other insecticides. 2 suggests that spinosad may affect insects that are predators of tomato pests, even at low concentrations. 3 demonstrated that spinosad is an effective insecticide against flies and was shown to be more effective than beta-cyfluthrin, a traditionally used insecticide. 11 revealed that while spinosad exhibits some toxicity to insects that transmit Chagas disease, it is safer than other insecticides. 9 showed that spinosad is effective in treating sheep blowfly larvae and was shown to be more effective than cyromazine, a traditionally used insecticide. 10 demonstrated that spinosad is effective in treating head lice and was shown to be more effective than permethrin, a traditionally used insecticide.

Benefits and Risks

Benefit Summary

Spinosad has been shown to be effective against a wide range of pests including fleas, lice, flies, medfly, golf course pests, and insects that transmit Chagas disease. It has also been suggested to be safer than traditional insecticides. Furthermore, spinosad has been shown to be less likely to develop resistance than traditional insecticides.

Risk Summary

Spinosad has been shown to exhibit some toxicity to beneficial insects such as bees. It has also been suggested that spinosad may affect insects that are predators of tomato pests, even at low concentrations.

Comparison Among Studies

Commonalities

Multiple studies have shown that spinosad has higher efficacy and safety compared to traditional insecticides.

Differences

While spinosad has been shown to be effective against a wide range of pests, its effectiveness varies depending on the type of pest and the concentration of spinosad. There are also differences in the results of studies regarding the toxicity of spinosad to beneficial insects.

Consistency and Inconsistencies of Results

Multiple studies have shown that spinosad has higher efficacy and safety compared to traditional insecticides. However, the results regarding the toxicity of spinosad to beneficial insects vary among studies, suggesting further investigation is required.

Points to Note Regarding Application in Real Life

While spinosad has been shown to be effective against a wide range of pests, it may exhibit some toxicity to beneficial insects. Therefore, when using spinosad, it is essential to consider its impact on beneficial insects.

Limitations of Current Research

Research on the safety and effectiveness of spinosad is not yet sufficient. In particular, further research is needed to understand the long-term effects of spinosad on humans and the environment.

Future Research Directions

Further research is needed on the safety and effectiveness of spinosad. In particular, detailed studies are required to understand the long-term effects of spinosad on humans and the environment. To investigate the effectiveness of spinosad in greater detail, studies comparing its efficacy against various pest species are needed. Furthermore, research is necessary to more accurately assess the toxicity of spinosad to beneficial insects.

Conclusion

Spinosad is a promising insecticide that can be effective against a variety of pests. However, it is essential to use caution when using it as it may exhibit some toxicity to beneficial insects. Further research on the safety and effectiveness of spinosad is required.

Literature analysis of 11 papers
Positive Content
10
Neutral Content
0
Negative Content
1
Article Type
2
0
0
1
11
1.

Lack of pharmacodynamic interaction of silodosin, a highly selective alpha1a-adrenoceptor antagonist, with the phosphodiesterase-5 inhibitors sildenafil and tadalafil in healthy men.

Author: MacDiarmidScott A, HillLawrence A, VolinnWeining, HoelGary

Safe coadministration
Mild adverse events

Co-administration of silodosin with sildenafil or tadalafil did not cause clinically significant orthostatic changes in blood pressure or heart rate in healthy men. The study found no significant differences in orthostatic effects between the treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Does the dose make the poison? Neurotoxic insecticides impair predator orientation and reproduction even at low concentrations.

Author: PassosLuis C, RicuperoMichele, GugliuzzoAntonio, SoaresMarianne A, DesneuxNicolas, CarvalhoGeraldo A, ZappalàLucia, BiondiAntonio

Pest control
Predator toxicity

This study assessed the toxicity of three neurotoxic insecticides on Nesidiocoris tenuis, a predator that controls insect pests in solanaceous crops, finding that even low doses can have negative effects on behavior and reproduction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Lethal and sub-lethal effects of select macrocyclic lactones insecticides on forager worker honey bees under laboratory experimental conditions.

Author: Abdu-AllahGamal A M, PittendrighBarry R

Honey bee safety
Selective insecticide
Insecticide toxicity

This study investigated the acute toxicity of four macrocyclic lactone insecticides to honey bees.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Cross-resistance Patterns to Insecticides of Several Chemical Classes Among Listronotus maculicollis (Coleoptera: Curculionidae) Populations With Different Levels of Resistance to Pyrethroids.

Author: KostromytskaOlga S, WuShaohui, KoppenhöferAlbrecht M

ABW control
pyrethroid resistance

This study investigated pyrethroid resistance in the annual bluegrass weevil (ABW), a significant pest of golf courses in eastern North America. The research found that pyrethroid resistance is widespread, including in the New York metropolitan area, New Jersey, and eastern Pennsylvania. The study also found cross-resistance to other insecticide classes, including chlorpyrifos, spinosad, clothianidin, and indoxacarb.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

7.

Effects of pesticides used on citrus grown in Spain on the mortality of Ceratitis capitata (Diptera: Tephritidae) Vienna-8 strain sterile males.

Author: Juan-BlascoMaría, Sabatier-MuñozBeatriz, ArgilésRafael, JacasJosep A, OrtegoFélix, UrbanejaAlberto

Medfly population control
Pesticide toxicity

The study investigated the effects of pesticides commonly used in citrus on Vienna-8 sterile males, which are used to reduce wild populations of the medfly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Safety and efficacy of spinosad chewable tablets for treatment of flea infestations of cats.

Author: PaarlbergTandy E, WisemanScott, TroutCandace M, KeeElizabeth A, SnyderDaniel E

FAD treatment
Flea control
Vomiting

Spinosad and selamectin both reduced flea counts and FAD scores for cats, although spinosad was more effective. Monthly oral administration of spinosad may be practical for treatment of flea infestations and FAD in cats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Spinosad for the treatment of head lice infestations.

Author: VillegasS C

Head lice treatment

This study discusses the use of spinosad 0.9% topical suspension, a novel agent with both pediculicidal and ovicidal activity, for the treatment of head lice infestations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Toxicity of non-pyrethroid insecticides against Triatoma infestans (Hemiptera: Reduviidae).

Author: CarvajalGuillermo, Mougabure-CuetoGastón, TolozaAriel Ceferino

Control Chagas disease

Fenitrothion and imidacloprid, non-pyrethroid insecticides, showed effective insecticidal activity against both deltamethrin-susceptible and deltamethrin-resistant populations of Triatoma infestans, a vector of Chagas disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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