Effective treatment of stroke: A Synthesis of Findings from 55 Studies

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Original Abstract of the Article

Major Research Findings

Stroke treatment has significantly advanced in recent decades, with two key advancements being the approval of intravenous chemical thrombolysis in 1995 and intra-arterial mechanical thrombectomy in 2015. 42 These treatments aim to improve blood flow to the brain by dissolving or removing blood clots that cause strokes, thus potentially reducing stroke symptoms and improving recovery. 42

Studies have demonstrated the effectiveness of these treatments, with earlier initiation showing greater potential for reducing stroke-related disabilities. 42 However, it's essential to acknowledge that the effectiveness and risks of these treatments can vary depending on factors such as the time of initiation and the individual patient's condition. 35

Furthermore, preventing stroke recurrence is crucial, as strokes are a leading cause of disability worldwide. 36 This includes managing risk factors like blood pressure and cholesterol, as well as avoiding smoking. 36

Treatment Summary

Stroke treatment options include thrombolytic therapy, endovascular therapy, and preventative medications.

Thrombolytic therapy involves dissolving blood clots in the brain using medications to restore blood flow. 42 、 26 This treatment is ideally started within 3 hours of stroke onset. 26

Endovascular therapy utilizes catheters to access brain vessels and directly remove blood clots. 42 This approach is used when thrombolytic therapy isn't effective or if the blockage is in a major blood vessel. 42

Preventive medications include antiplatelet agents like aspirin and anticoagulants like warfarin. 52 These medications are prescribed to reduce the risk of stroke recurrence. 36

Benefits and Risks

Benefit Summary

Stroke treatments, especially when initiated early, have the potential to reduce stroke-related disabilities. 42 Additionally, taking appropriate preventative medications can help prevent stroke recurrence. 36

Risk Summary

Stroke treatments carry risks, including bleeding. 42 Thrombolytic therapy is ideally initiated within 3 hours of stroke onset, and delaying treatment can lead to reduced effectiveness. 26

Comparison Across Studies

Study Commonalities

Numerous studies indicate the effectiveness of thrombolytic and endovascular therapies as stroke treatments. 42 、 35

Study Differences

Variations exist across studies in terms of the patient population, treatment initiation timing, and observed effectiveness and risks. 35

Consistency and Contradictions in Results

While consistent results regarding the effectiveness of stroke treatments are found in many studies, some research reports contradictory findings. 14 These discrepancies can be attributed to differences in the patient populations, treatment methods, and assessment techniques employed in each study. 35

Practical Application Notes

Stroke treatments are tailored to individual patients. 35 Therefore, adhering to physician instructions and receiving appropriate treatment is crucial. 35 Moreover, stroke prevention is essential, and maintaining a healthy lifestyle is paramount. 36

Limitations of Current Research

There are still unanswered questions regarding stroke treatment. 37 These include the mechanisms of stroke, the long-term effects of treatments, and determining the optimal treatment choices for individual patients. 3

Future Research Directions

Future research on stroke treatment should focus on developing new and more effective treatments, optimizing existing treatment methods, and improving stroke prevention strategies. 43 The development of even more effective and safe treatments is a key goal for the future. 45

Conclusion

Prompt treatment for stroke is critical, and appropriate interventions can potentially reduce stroke-related disabilities. 42 Stroke prevention is equally important, and maintaining a healthy lifestyle is crucial. 36 If you have any concerns about stroke, consulting a healthcare professional is recommended.

Treatment List

• Thrombolytic therapy

• Endovascular therapy

• Antiplatelet medications

• Anticoagulants

Keywords
Benefit Keywords
Stroke treatment
3
Improved self-care
4
Dissolves thrombus
6
Improved discharge outcomes
Reduced mortality
7
Better functional state
Home living
Improved survival
8
Reduced disability
9
Stroke prevention
10
Improved quality of life
12
Reduced disability
Reduced mortality
13
Early discharge
Improved functional outcome
Improved survival
14
Improved stroke outcomes
15
Improved stroke recovery
16
Improved mood
18
Antidepressant drugs
19
Stroke treatment
21
Reduced stroke risk
22
Improved stroke treatment
23
Effective stroke treatment
24
Improved stroke treatment
25
Nimodipine for SAH
Stroke treatment
26
Improved stroke recovery
27
Effective treatment
Improved stroke outcomes
28
Improved stroke treatment
29
Improved stroke rehabilitation
30
Improved stroke outcome
Reduced stroke-related death
31
Secondary prevention
Stroke prevention
32
Stroke recovery
34
Ischemic stroke treatment
35
Beta-blockers for stroke prevention
36
Functional outcome
Stroke treatment
38
Stroke treatment
39
Improved outcome
40
Endovascular treatment
41
Improved stroke treatment
42
Not applicable
43
Reduced stroke recurrence
44
Improved stroke outcome
Reduced neurological deficits
45
Acute ischemic stroke treatment
Endovascular therapy
46
Stroke treatment
47
Stroke treatment
48
EVT for AIS
49
Improved reperfusion
50
Stroke treatment
51
Reduced stroke recurrence
52
Reduced care time
53
Secondary stroke prevention
Stroke recovery
54
Post-stroke disability reduction
Stroke mortality reduction
55
Risk Keywords
Stroke treatment inconclusive
1
Stroke risk
2
Edema
Hematoma
Herniation
6
Limited access to stroke units
7
Increased haemorrhage
9
Stroke
12
Intracranial hemorrhage
15
Fatal bleeding
16
Aspirin ineffectiveness
17
Depression
Stroke
19
Depression
20
Haemorrhage
22
Stroke
23
Stroke
25
Anticoagulant limitations
Neuroprotectant failure
26
Brain bleeding
27
Intracranial hemorrhage
28
Brain bleeding
34
Intracerebral hemorrhage
Mortality
38
Increased mortality
Neurological deterioration
43
Increased bleeding
44
Increased hemorrhage risk
45
Thrombolysis delivery
47
Post-cardiac surgery stroke
48
Major bleeding risk
52
Lack of clarity on study population
53
Asymptomatic intracerebral hemorrhage
55
Literature analysis of 55 papers
Positive Content
49
Neutral Content
2
Negative Content
4
Article Type
32
10
20
17
54
1.

Is there a real treatment for stroke? Clinical and statistical comparison of different treatments in 300 patients.

Author: SantambrogioS, MartinottiR, SardellaF, PorroF, RandazzoA

Stroke treatment inconclusive

A study of 300 patients with stroke compared the effectiveness of standard supportive care with the addition of Hydergine, dexamethasone, or mannitol. No statistically significant difference in outcomes was observed between any of the treatment groups and the group receiving only supportive care within the first 10 days after stroke. The study concluded that, at the doses used, these additional medications did not provide a benefit over standard supportive care for stroke patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The risk of stroke in patients with acute myocardial infarction after thrombolytic and antithrombotic treatment. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico II (GISSI-2), and The International Study Group.

Author: MaggioniA P, FranzosiM G, SantoroE, WhiteH, Van de WerfF, TognoniG

Stroke risk

Thrombolytic therapy for acute myocardial infarction does not significantly increase the risk of stroke compared to conventional treatment. However, further research is needed to understand the incidence of various stroke types and the impact of risk factors across different thrombolytic and antithrombotic regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The pragmatic approach to stroke trial design: stroke register, pilot trial, assessment of neurological then functional outcome.

Author: BarerD H, EbrahimS B, MitchellJ R

Stroke treatment

This paper discusses the challenges and considerations for designing and conducting clinical trials for acute stroke.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Therapy impact on functional outcome in a controlled trial of stroke rehabilitation.

Author: SmithM E, GarrawayW M, SmithD L, AkhtarA J

Improved self-care

This study compared stroke unit care with medical unit care for elderly patients. Patients in the stroke unit were more likely to be independent in self-care, despite similar neurological impairments. While stroke unit patients received less therapy overall, they started occupational therapy earlier after admission. These findings suggest that starting rehabilitation early may be more important than the total amount of therapy time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.

Author: AdamsH P, BendixenB H, KappelleL J, BillerJ, LoveB B, GordonD L, MarshE E

This study developed a system to classify types of ischemic stroke based on their cause. This classification system will be used in clinical trials for acute stroke treatment to better understand how different types of stroke respond to various therapies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Thrombolysis acute ischemic stroke.

Author: FieschiC, CavallettiC, ToniD, FiorelliM, SacchettiM L, De MicheleM, GoriM C, MontinaroE, ArgentinoC

Dissolves thrombus
Edema
Hematoma
Herniation

This study explores the use of thrombolysis (clot-busting treatment) for stroke. While promising in dissolving clots, it can also cause complications like bleeding or swelling in the brain. The study found that the size of the affected area on a CT scan within 5 hours of stroke onset can predict the risk of bleeding. The European Co-operative Acute Stroke Study (ECASS) excluded patients with large areas of damage on their initial CT scan from receiving thrombolysis. Ongoing trials aim to further refine patient selection for thrombolysis to maximize benefits and minimize risks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

[Apoplexy units--reduced mortality, need for nursing homes, length of stay and cost savings].

Author: JørgensenH S, NakayamaH, RaaschouH O, LarsenK J, HübbeP, OlsenT S

Improved discharge outcomes
Reduced mortality
Limited access to stroke units

This study found that treatment on a specialized stroke unit significantly reduced in-hospital mortality, case-fatality rate, 6-month and 1-year mortality, and discharge rate to a nursing home compared to treatment on a general neurological/medical ward.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Danish

8.

Stroke unit treatment. Long-term effects.

Author: IndredavikB, SlørdahlS A, BakkeF, RoksethR, HåheimL L

Better functional state
Home living
Improved survival

Stroke unit care was shown to improve long-term survival and functional state, increasing the proportion of patients able to live at home 5 years after a stroke.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

[Thrombolytic therapy in stroke. What do clinical tests prove?].

Author: LindbergP J, KasteM

Reduced disability
Increased haemorrhage

While treatment with rt-PA (a clot-busting drug) within 3 hours of stroke onset has shown to reduce disability by 30% at 3 months, the risk of bleeding in the brain remains a concern. Until better guidelines for using rt-PA are established, this treatment should be limited to specialized centers. The study also emphasizes the importance of public awareness regarding the need for immediate specialized care for stroke patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Swedish

10.

[When is lipid-lowering therapy appropriate for stroke?].

Author: TeréntA

Stroke prevention

This study discussed the potential benefits of cholesterol-lowering medication for secondary stroke prevention, noting that while large trials focused on heart disease had shown a reduction in cardiovascular events, those trials involved younger patients than typical stroke populations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Swedish

11.

Stroke unit versus general medical wards, II: neurological deficits and activities of daily living: a quasi-randomized controlled trial.

Author: RønningO M, GuldvogB

This study investigates the effectiveness of stroke units, considering the recent improvements in stroke care in general medicine. The research focuses on patients admitted early with short hospital stays, determining if stroke units still provide a benefit and identifying key components of successful stroke unit care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Stroke unit treatment improves long-term quality of life: a randomized controlled trial.

Author: IndredavikB, BakkeF, SlørdahlS A, RoksethR, HåheimL L

Improved quality of life
Stroke

This study investigated the effect of treatment in a combined acute and rehabilitation stroke unit on quality of life (QoL) for stroke patients 5 years after the onset of stroke.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Protocol for the Multicenter Acute Stroke Trial--thrombolysis study.

Author:

Reduced disability
Reduced mortality

This study describes the rationale for the Multicenter Acute Stroke Trial (MAST), highlighting the need for effective treatments for acute ischemic stroke, a major cause of death and disability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Treatment in a combined acute and rehabilitation stroke unit: which aspects are most important?

Author: IndredavikB, BakkeF, SlordahlS A, RoksethR, HâheimL L

Early discharge
Improved functional outcome
Improved survival

This study aimed to identify the differences in treatment between a stroke unit (SU) and general ward (GW) and to assess which aspects of SU care were most responsible for improved outcomes in stroke patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study.

Author: MarlerJ R, TilleyB C, LuM, BrottT G, LydenP C, GrottaJ C, BroderickJ P, LevineS R, FrankelM P, HorowitzS H, HaleyE C, LewandowskiC A, KwiatkowskiT P

Improved stroke outcomes
Intracranial hemorrhage

This study analyzed data from the NINDS rt-PA Stroke Study to further characterize the relationship between onset-to-treatment time (OTT) and outcomes, including early improvement and intracranial hemorrhage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Thrombolysis for acute ischaemic stroke.

Author: WardlawJ M, ZoppoG, YamaguchiT, BergeE

Improved stroke recovery
Fatal bleeding

Most strokes are caused by blood clots blocking arteries in the brain. Giving clot-busting medications quickly can restore blood flow and improve recovery from stroke. However, these medications also increase the risk of serious brain bleeding, which can be fatal. Several studies have investigated the use of clot-busting medication for stroke.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Aspirin in the prevention of progressing stroke: a randomized controlled study.

Author: Rödén-JülligA, BrittonM, MalmkvistK, LeijdB

Aspirin ineffectiveness

This study evaluated the efficacy of aspirin for preventing stroke progression in patients with ischemic stroke. The study found that aspirin treatment did not significantly reduce the frequency of stroke progression or improve patient outcome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Interventions for preventing depression after stroke.

Author: AndersonC S, HackettM L, HouseA O

Improved mood

The study examines the importance of addressing abnormal mood in stroke patients, including the potential benefits of early anti-depressant treatment for preventing depression and improving outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

[Depression: an underrated consequence of stroke in elderly].

Author: Pariel-MadjlessiSylvie, PouillonMarianne, RobcisIngrid, SebbanClaude, FrémontPatrick, BelminJoël

Antidepressant drugs
Depression
Stroke

Post-stroke depression is common and can impact functional recovery. Early identification and treatment with antidepressants can improve depressive symptoms and functional recovery in stroke patients.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

20.

Predictors of depression after stroke: a systematic review of observational studies.

Author: HackettMaree L, AndersonCraig S

Depression

This study found that there is a paucity of well-designed studies of sufficient size to allow stable multivariate predictive models of depression after stroke to be developed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Naftidrofuryl for acute stroke.

Author: Leonardi-BeeJ, SteinerT, Bath-HextallF

Stroke treatment

Stroke is a major cause of death and disability. While research continues on developing new treatments, there is no widely effective treatment available. This study examines the effectiveness of naftidrofuryl, a medication that has been suggested as a potential treatment for stroke, by reviewing available research. The study aims to determine if the evidence supports the use of naftidrofuryl for stroke.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.

Author: KennedyJames, HillMichael D, RyckborstKarla J, EliasziwMichael, DemchukAndrew M, BuchanAlastair M,

Reduced stroke risk
Haemorrhage

This study found that clopidogrel in addition to aspirin may reduce the risk of stroke in patients with transient ischemic attack (TIA) or minor stroke within 90 days. However, the study was stopped early due to low recruitment rates and was unable to provide evidence of benefit for simvastatin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Recommendations and treatment strategies for the management of acute ischemic stroke.

Author: SeguraTomás, CallejaSergio, JordanJoaquin

Improved stroke treatment
Stroke

Stroke is a major cause of death and disability globally. Understanding that the brain tissue affected by a stroke is not immediately damaged (penumbra concept) has led to two main treatment strategies: reopening the blocked artery and protecting the vulnerable brain tissue until the blockage is resolved or treatment stops the damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Promoting Acute Thrombolysis for Ischaemic Stroke (PRACTISE).

Author: DirksMaaike, NiessenLouis W, HuijsmanRobbert, van WijngaardenJeroen, MinkmanMirella M N, FrankeCees L, van OostenbruggeRobert J, KoudstaalPeter J, DippelDiederik W J,

Effective stroke treatment

Barriers to broad implementation of thrombolysis for acute ischemic stroke are discussed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Design of the economic evaluation for the Interventional Management of Stroke (III) trial.

Author: MauldinPatrick D, SimpsonKit N, PaleschYuko Y, SpilkerJudy S, HillMichael D, KhatriPooja, BroderickJoseph P,

Improved stroke treatment
Stroke

Stroke is a common and expensive condition. Early treatment can improve a person's quality of life and reduce the cost of acute care and ongoing support. To guide decisions about adopting new treatments, economic analyses should be included in research on improving outcomes for stroke patients.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

26.

[Pharmacotherapy of stroke].

Author: BereczkiDániel

Nimodipine for SAH
Stroke treatment
Anticoagulant limitations
Neuroprotectant failure

This study discusses the treatment of stroke, a major health concern with 85% of cases being ischemic (caused by blocked blood flow) and 15% hemorrhagic (caused by bleeding). The only proven treatment for ischemic stroke is a clot-busting medication (thrombolysis) given within 3 hours of symptoms. Research on extending the treatment window and new medications is ongoing. While some studies showed promise, no neuroprotective medications have been found to be effective in treating stroke. Anti-clotting medications like heparin are not recommended for routine use. Aspirin can be safely given within 48 hours and may slightly reduce the risk of death or disability. There is no proven medication for treating bleeding in the brain (intracerebral hemorrhage). For bleeding in the space around the brain (subarachnoid hemorrhage), nimodipine helps prevent blood vessel spasms. While research on statins is mixed, they may have a similar protective effect. The study emphasizes the importance of preventing stroke as there are limited treatment options once it occurs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Hungarian

27.

Thrombolysis for acute ischaemic stroke.

Author: WardlawJoanna M, MurrayVeronica, BergeEivind, Del ZoppoGregory J

Improved stroke recovery
Brain bleeding

This article discusses the use of thrombolytic drugs for the treatment of stroke and the risks and benefits associated with these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

The effectiveness of thrombolysis with intravenous alteplase for acute ischemic stroke in daily practice.

Author: DirksMaaike, NiessenLouis W, van WijngaardenJeroen, KoudstaalPeter J, FrankeCees L, van OostenbruggeRobert J, DippelDiederik W J,

Effective treatment
Improved stroke outcomes
Intracranial hemorrhage

Thrombolysis with intravenous alteplase was an effective treatment for ischemic stroke in an unselected observational cohort of patients. Treatment with alteplase was associated with a favorable outcome, with a 5% symptomatic intracranial bleeding complication rate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial.

Author: WalterSilke, KostopoulosPanagiotis, HaassAnton, KellerIsabel, LesmeisterMartin, SchlechtriemenThomas, RothChristian, PapanagiotouPanagiotis, GrunwaldIris, SchumacherHelmut, HelwigStephan, VieraJulio, KörnerHeiko, AlexandrouMaria, YilmazUmut, ZieglerKarin, SchmidtKathrin, DabewRainer, KubulusDarius, LiuYang, VolkThomas, KronfeldKai, RuckesChristian, BertschThomas, ReithWolfgang, FassbenderKlaus

Improved stroke treatment

This study aims to assess the efficacy of a new approach to stroke diagnosis and treatment that starts at the emergency site, rather than after hospital arrival, to reduce delays in therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

The effects of a rhythm and music-based therapy program and therapeutic riding in late recovery phase following stroke: a study protocol for a three-armed randomized controlled trial.

Author: Bunketorp KällLina, Lundgren-NilssonÅsa, BlomstrandChristian, PeknaMarcela, PeknyMilos, NilssonMichael

Improved stroke rehabilitation

Rehabilitation programs incorporating rhythm and music and therapeutic riding are being investigated for their effectiveness in treating stroke patients in the late phase. However, more research is needed to determine their efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Importance of proper patient selection and endpoint selection in evaluation of new therapies in acute stroke: further analysis of the SENTIS trial.

Author: ShuaibAshfaq, SchwabStefan, RutledgeJ Neal, StarkmanSidney, LiebeskindDavid S, BernardiniGary L, BoulosAlan, Abou-CheblAlex, HuangDavid Y, VanhoorenGeert, Cruz-FloresSalvador, KlucznikRichard Paul, SaverJeffrey L,

Improved stroke outcome
Reduced stroke-related death

Rapid treatment and initial stroke severity have a significant impact on outcome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Beta-blockers for preventing stroke recurrence.

Author: De LimaLuiz Gustavo, SoaresBernardo G O, SaconatoHumberto, AtallahAlvaro N, da SilvaEdina M K

Secondary prevention
Stroke prevention

Stroke is a major health problem with a high rate of recurrence. This study will investigate the role of beta-blockers in the secondary prevention of stroke.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design.

Author: JohnstonS Claiborne, EastonJ Donald, FarrantMary, BarsanWilliam, BattenhouseHolly, ConwitRobin, DillonCatherine, ElmJordan, LindbladAnne, MorgensternLewis, PoissonSharon N, PaleschYuko

Within the first three months after a transient ischemic attack (TIA) or minor stroke, 10-20% of people experience another stroke or other vascular problems, many of which are disabling. The highest risk period is in the hours and days immediately following the initial event. Aspirin is the most common medication used to prevent blood clots in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

34.

Thrombolysis for acute ischaemic stroke.

Author: WardlawJoanna M, MurrayVeronica, BergeEivind, del ZoppoGregory J

Stroke recovery
Brain bleeding

Most strokes are caused by blood clots blocking arteries in the brain. Clot-busting medications can restore blood flow and improve recovery in some people, but they can also cause dangerous brain bleeds. One drug, rt-PA, is approved for use within 4.5 hours of a stroke in Europe and within 3 hours in the US. There are age limits and restrictions on the severity of stroke in some countries. There is more recent research (40% more) since the last review in 2009.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.

Author: EmbersonJonathan, LeesKennedy R, LydenPatrick, BlackwellLisa, AlbersGregory, BluhmkiErich, BrottThomas, CohenGeoff, DavisStephen, DonnanGeoffrey, GrottaJames, HowardGeorge, KasteMarkku, KogaMasatoshi, von KummerRuediger, LansbergMaarten, LindleyRichard I, MurrayGordon, OlivotJean Marc, ParsonsMark, TilleyBarbara, ToniDanilo, ToyodaKazunori, WahlgrenNils, WardlawJoanna, WhiteleyWilliam, del ZoppoGregory J, BaigentColin, SandercockPeter, HackeWerner,

Ischemic stroke treatment

Alteplase is a medication used to treat stroke caused by blood clots. This study investigates how factors like the time since stroke onset, age, and stroke severity affect the likelihood of a good outcome after treatment with alteplase.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

36.

Beta-blockers for preventing stroke recurrence.

Author: De LimaLuiz Gustavo, SaconatoHumberto, AtallahAlvaro N, da SilvaEdina M K

Beta-blockers for stroke prevention

Stroke is a major public health concern, with high recurrence rates. This review discusses the role of beta-blockers in secondary stroke prevention, emphasizing their effects beyond blood pressure reduction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Systematic review of survival time in experimental mouse stroke with impact on reliability of infarct estimation.

Author: KlarskovCarina Kirstine, KlarskovMikkel Buster, HasseldamHenrik, JohansenFlemming Fryd

Stroke is a major cause of death worldwide. While there is one treatment available for acute stroke (thrombolysis), its use is limited. Research has focused on finding additional treatments, but there have been challenges in translating results from animal studies to human trials. This is likely due to differences in how stroke affects the brain in mice versus humans, particularly in terms of swelling (edema).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Endovascular Treatment with Stent-Retriever Devices for Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.

Author: BushChad K, KurimellaDayaamayi, CrossLee J S, ConnerKatherine R, Martin-SchildSheryl, HeJiang, LiChangwei, ChenJing, KellyTanika

Functional outcome
Stroke treatment
Intracerebral hemorrhage
Mortality

Patients receiving endovascular treatment experienced 2.22 times greater odds of better functional outcome compared to those randomized to medical management. Further, this analysis showed that acute ischemic stroke patients may receive enhanced functional benefit from earlier endovascular treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

39.

Topographic distribution of cerebral infarct probability in patients with acute ischemic stroke: mapping of intra-arterial treatment effect.

Author: BoersA M M, BerkhemerO A, SlumpC H, van ZwamW H, RoosY B W E M, van der LugtA, van OostenbruggeR J, YooA J, DippelD W J, MarqueringH A, MajoieC B L M,

Stroke treatment

While intravenous thrombolysis (IAT) is the standard treatment for acute ischemic stroke, only about one-third of patients achieve full recovery. While functional outcome is often used to assess IAT effectiveness, understanding the treatment's effect on brain tissue salvage is crucial to improve patient selection and treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Effects of Alteplase for Acute Stroke on the Distribution of Functional Outcomes: A Pooled Analysis of 9 Trials.

Author: LeesKennedy R, EmbersonJonathan, BlackwellLisa, BluhmkiErich, DavisStephen M, DonnanGeoffrey A, GrottaJames C, KasteMarkku, von KummerRüdiger, LansbergMaarten G, LindleyRichard I, LydenPatrick, MurrayGordon D, SandercockPeter A G, ToniDanilo, ToyodaKazunori, WardlawJoanna M, WhiteleyWilliam N, BaigentColin, HackeWerner, HowardGeorge,

Improved outcome

This study assessed the effect of alteplase on the distribution of functional outcomes after ischemic stroke, considering treatment delay, age, and stroke severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Endovascular thrombectomy and medical therapy versus medical therapy alone in acute stroke: A randomized care trial.

Author: KhouryNaim N, DarsautTim E, GhostineJimmy, DeschaintreYan, DaneaultNicole, DurocherAndré, LanthierSylvain, PoppeAlexandre Y, OdierCéline, LebrunLouise-Hélène, GuilbertFrançois, GentricJean-Christophe, BatistaAndré, WeillAlain, RoyDaniel, BracardSerge, RaymondJean,

Endovascular treatment

This study implemented a care trial for patients with acute ischemic stroke to evaluate the benefits of endovascular treatment. The study found that endovascular treatment was not significantly better than standard care at improving functional outcomes at 3 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Thrombolytic therapies for ischemic stroke: Triumphs and future challenges.

Author: MoussaddyAimen, DemchukAndrew M, HillMichael D

Improved stroke treatment

Stroke treatment has significantly improved in recent decades, with the introduction of clot-busting medications (thrombolysis) and minimally invasive procedures to remove clots (thrombectomy). Current research focuses on identifying who is most likely to benefit from these treatments, as well as exploring the use of new medications and combining treatments. A key area of research is understanding the best ways to combine medication and procedures to improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Frequency, Predictors, and Outcomes of Prehospital and Early Postarrival Neurological Deterioration in Acute Stroke: Exploratory Analysis of the FAST-MAG Randomized Clinical Trial.

Author: ShkirkovaKristina, SaverJeffrey L, StarkmanSidney, WongGregory, WengJulius, HamiltonScott, LiebeskindDavid S, EcksteinMarc, StrattonSamuel, PrattFrank, ConwitRobin, SanossianNerses,

Not applicable
Increased mortality
Neurological deterioration

Neurological deterioration, defined as a worsening of 2 or more points on the Glasgow Coma Scale, occurs in 1 in 8 patients transported by ambulance with acute cerebrovascular disease. This deterioration was more common among patients with intracranial hemorrhage (1 in 3) than those with acute cerebral ischemia (1 in 16). The deterioration is associated with reduced functional independence and increased mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT.

Author: BathPhilip M, WoodhouseLisa J, AppletonJason P, BeridzeMaia, ChristensenHanne, DineenRobert A, FlahertyKatie, DuleyLelia, EnglandTimothy J, HavardDiane, HeptinstallStan, JamesMarilyn, KasondeChibeka, KrishnanKailash, MarkusHugh S, MontgomeryAlan A, PocockStuart, RandallMarc, RantaAnnamarei, RobinsonThompson G, ScuttPolly, VenablesGraham S, SpriggNikola

Reduced stroke recurrence
Increased bleeding

The use of three antiplatelet agents for acute ischaemic stroke or TIA was associated with increased bleeding without any significant reduction in the recurrence of stroke or TIA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

Author: MaHenry, CampbellBruce C V, ParsonsMark W, ChurilovLeonid, LeviChristopher R, HsuChung, KleinigTimothy J, WijeratneTissa, CurtzeSami, DeweyHelen M, MiteffFerdinand, TsaiChon-Haw, LeeJiunn-Tay, PhanThanh G, MahantNeil, SunMu-Chien, KrauseMartin, SturmJonathan, GrimleyRohan, ChenChih-Hung, HuChaur-Jong, WongAndrew A, FieldDeborah, SunYu, BarberP Alan, SabetArman, JannesJim, JengJiann-Shing, ClissoldBenjamin, MarkusRomesh, LinChing-Huang, LienLi-Ming, BladinChristopher F, ChristensenSøren, YassiNawaf, SharmaGagan, BivardAndrew, DesmondPatricia M, YanBernard, MitchellPeter J, ThijsVincent, CareyLeeanne, MeretojaAtte, DavisStephen M, DonnanGeoffrey A,

Improved stroke outcome
Reduced neurological deficits
Increased hemorrhage risk

Alteplase administered between 4.5 and 9.0 hours after stroke onset resulted in a higher percentage of patients with no or minor neurologic deficits than placebo.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

TRIAGE-STROKE: Treatment strategy In Acute larGE vessel occlusion: Prioritize IV or endovascular treatment-A randomized trial.

Author: BehrndtzAnne, JohnsenSøren P, ValentinJan B, GudeMartin F, BlauenfeldtRolf A, AndersenGrethe, MajoieCharles Blm, FisherMarc, SimonsenClaus Z

Acute ischemic stroke treatment
Endovascular therapy

For severe strokes caused by blockages in major blood vessels, both clot-busting medication (intravenous thrombolysis) and a procedure to remove the clot (endovascular therapy) are used. While endovascular therapy is more effective, it's unclear which way to transport patients with these strokes to a specialized stroke center is best. The study aims to find the optimal transport strategy for patients with severe strokes.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Effect of an Enhanced Paramedic Acute Stroke Treatment Assessment on Thrombolysis Delivery During Emergency Stroke Care: A Cluster Randomized Clinical Trial.

Author: PriceChristopher I, ShawLisa, IslamSaiful, JavanbakhtMehdi, WatkinsAlan, McMeekinPeter, SnooksHelen, FlynnDarren, FrancisRichard, LakeyRachel, SutcliffeLou, McClellandGraham, LallyJoanne, ExleyCatherine, RodgersHelen, RussellIan, ValeLuke, FordGary A

Stroke treatment
Thrombolysis delivery

A cluster-randomized trial of 1214 patients with acute ischemic stroke found that an enhanced paramedic assessment did not facilitate thrombolysis delivery. However, the unexpected combination of thrombolysis and health outcomes suggests possible alternative influences on treatment decisions requiring further evaluation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Postcardiac Surgery Acute Stroke Therapies: A Systematic Review.

Author: KashaniHessam H, MosienkoLucas, GrocottBronwen B, GlezersonBryan A, GrocottHilary P

Stroke treatment
Post-cardiac surgery stroke

A review of 8 case reports/series and 2 retrospective studies found that endovascular thrombectomy, with or without intra-arterial thrombolysis (IAT), is being used increasingly with success in patients presenting with postcardiac surgery stroke. However, the number of patients reported is too small to confidently understand its overall effect on neurologic outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke.

Author: RoaldsenMelinda B, LindekleivHaakon, MathiesenEllisiv B

Improved reperfusion

Wake-up strokes, which occur during sleep, have traditionally been considered ineligible for thrombolytic treatment due to uncertainty about the time of onset. However, recent studies suggest potential benefits of recanalisation therapies in selected patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Edaravone for acute ischemic stroke - Systematic review with meta-analysis.

Author: FidalgoMariana, Ricardo PiresJoana, ViseuInês, MagalhãesPedro, GregórioHugo, AfreixoVera, GregórioTiago

Stroke treatment

Stroke is a major cause of death and disability. While treatments exist to restore blood flow to the brain, they only work within a limited time frame, and most people aren't eligible. A medication called edaravone has been shown to help reduce brain damage in some stroke patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials.

Author: TornyosDániel, KomócsiAndrás, BálintAlexandra, KupóPéter, El AbdallaouiOumaima El Alaoui, SzapáryLászló, SzapáryLászló Botond

Reduced stroke recurrence
Major bleeding risk

Cilostazol was most effective in reducing stroke recurrence and bleeding risk compared to aspirin. Intensified antiplatelet regimens with aspirin and ticagrelor or clopidogrel resulted in lower stroke recurrence but higher bleeding risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Reducing care time after implementing protocols for acute ischemic stroke: a systematic review.

Author: LeiteKarina Fonseca de Souza, Dos SantosSamuel Ribeiro, AndradeRubia Laine de Paula, de FariaMariana Gaspar Botelho Funari, SaitaNanci Michele, ArcêncioRicardo Alexandre, IsaacIgor Simões da Silva, de RezendeCarlos Eduardo Menezes, VillaTereza Cristina Scatena, Pontes NetoOctavio Marques, MonroeAline Aparecida

Reduced care time
Lack of clarity on study population

Implementing protocols for acute ischemic stroke improved door-to-image, image-to-needle, door-to-needle, and symptoms-onset-to-needle times, but not symptoms-onset-to-door time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

The effect of polyphenols in post stroke adults: A systematic review of randomised controlled trials.

Author: BayesJ, BedasoA, PengW, AdamsJ, SibbrittD

Secondary stroke prevention
Stroke recovery

This review highlights the promising role of polyphenols in stroke rehabilitation and reducing risk factors for secondary stroke.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

55.

Endovascular Treatment plus Medical Treatment versus Medical Treatment Alone in Ischemic Stroke: A Systematic Review and Meta-Analysis.

Author: ToubasiAhmad A, Al-SayeghThuraya N, AlbustanjiFarah H, Al-HarasisLayla M

Post-stroke disability reduction
Stroke mortality reduction
Asymptomatic intracerebral hemorrhage

This systematic review and meta-analysis of 22 randomized controlled trials found that endovascular treatment combined with medical therapy is superior to medical therapy alone in the management of stroke, reducing disability and mortality.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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