Effective treatment of syringomyelia: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

Syringomyelia is a debilitating and progressive disease characterized by fluid-filled cavities within the spinal cord. 4 These cavities can cause various symptoms, including pain, weakness, numbness, and difficulty with bowel and bladder control. 15 In severe cases, syringomyelia can lead to paralysis. 15 The underlying cause of syringomyelia can vary, with some cases linked to conditions like Chiari malformation or spinal cord injury. 6

While syringomyelia is often associated with Chiari malformation, there are other causes such as arachnoiditis, tethered cord syndrome, and even tuberculosis meningitis. 19 1 3

Current treatment options for syringomyelia primarily focus on surgical interventions, aiming to relieve pressure on the spinal cord and allow for proper CSF flow. 4 These include procedures such as posterior fossa decompression, duraplasty, and syrinx shunting. 14 9

However, there is a growing interest in exploring non-surgical approaches. For example, research into the potential of stem cell therapy for syringomyelia is ongoing. 15

Treatment Summary

The primary treatment for syringomyelia is surgical intervention, aimed at relieving pressure on the spinal cord and restoring normal CSF flow. 4 Surgical options include posterior fossa decompression, duraplasty, and syrinx shunting. 14 9

Stem cell therapy shows promise as a potential non-surgical treatment option, but further research is needed. 15

Benefits and Risks

Benefits Summary

Treatment for syringomyelia can lead to symptom relief, improved neurological function, and enhanced quality of life. 4

Risks Summary

Surgical interventions for syringomyelia carry inherent risks, including potential for failure, recurrence, and complications. 15

Comparison between Studies

Commonalities between Studies

Multiple studies highlight the effectiveness of surgical interventions in treating syringomyelia. 4 14

Differences between Studies

Different studies focus on specific aspects of syringomyelia treatment, such as the effectiveness of various shunting procedures, the impact of socioeconomic factors on treatment access, and the potential benefits of stem cell therapy. 4 16 15

Consistency and Contradictions in Findings

While the effectiveness of surgical treatment for syringomyelia is widely acknowledged, the optimal surgical approach and the long-term outcomes can vary depending on the individual case. 4

Ongoing research is exploring the potential of non-surgical treatments, such as stem cell therapy, to provide alternative options for syringomyelia management. 15

Implications for Daily Life

Individuals diagnosed with syringomyelia should seek medical guidance from a qualified healthcare professional to discuss appropriate treatment options. 16

Limitations of Current Research

Research on syringomyelia treatment is still ongoing, and further studies are needed to gain a more comprehensive understanding of the disease, its various causes, and the effectiveness of different treatment approaches. 18

Future Directions for Research

Future research should focus on developing novel treatment strategies, enhancing the effectiveness of existing treatments, minimizing potential complications, and exploring new non-surgical options for managing syringomyelia. 18 15

Conclusion

Syringomyelia is a challenging condition, requiring careful diagnosis and appropriate treatment. 4 While surgical interventions remain the primary treatment approach, ongoing research into non-surgical options holds promise for improving outcomes for individuals affected by this condition. 15

If you are experiencing symptoms that might be related to syringomyelia, it is important to seek medical attention promptly for accurate diagnosis and timely intervention. 16

Treatment List

  • Posterior fossa decompression
  • Duraplasty
  • Syrinx shunting
  • Stem cell therapy
  • Spinal cord stimulation
  • Foramen magnum decompression (FMD)
  • Atlantoaxial fusion
  • Fourth ventricle-subarachnoid shunt (FVSS)
Literature analysis of 21 papers
Positive Content
17
Neutral Content
0
Negative Content
4
Article Type
2
1
4
1
19
1.

Treatment of terminal syringomyelia in association with tethered cord syndrome: clinical outcomes with and without syrinx drainage.

Author: ErkanK, UnalF, KirisT, KaralarT

Tethered cord syndrome treatment

The study aimed to assess the clinical impact of syrinx decompression on the clinical outcome of tethered cord syndrome, given the increased awareness of the frequency of terminal syringomyelia in patients with this condition.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Treatment of posttraumatic syringomyelia: evidence from a systematic review.

Author: KleindienstAndrea, LautFrancisco Marin, RoeckeleinVerena, BuchfelderMichael, Dodoo-SchittkoFrank

PTS treatment

After a spinal cord injury (SCI), a condition called posttraumatic syringomyelia (PTS) is often found on MRI scans. While surgery has been the preferred treatment for decades, there's no clear agreement on the best approach. This review examines the different treatments for PTS, their effectiveness, and potential risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Management of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature.

Author: KannapadiNivedha V, AlomariSafwan O, CaturegliGiorgio, BydonAli, ChoSung-Min

TB syringomyelia treatment

This study investigated the characteristics and outcomes of tuberculosis (TB) syringomyelia, a condition where a fluid-filled cavity forms in the spinal cord due to TB infection. The study reviewed 33 cases of TB syringomyelia and found that while surgery was more common for those with TB meningitis, there was no clear difference in symptom improvement between surgical and medical management. More research is needed to determine the best treatment approach for TB syringomyelia.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Syrinx shunts for syringomyelia: a systematic review and meta-analysis of syringosubarachnoid, syringoperitoneal, and syringopleural shunting.

Author: RothrockRobert J, LuVictor M, LeviAllan D

Evidence-based comparison
Improved syringomyelia treatment

Syringomyelia is a progressive condition that can lead to loss of function in people who already have nerve damage. There are different types of shunts used to treat it, but there's been a lack of direct comparisons between them. This review will examine research to compare the outcomes of different shunt procedures: syringosubarachnoid, syringoperitoneal, and syringopleural shunts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Chiari Type 1 Malformation and Syringomyelia in Children: Classification and Treatment Options.

Author: SolemanJehuda, RothJonathan, ConstantiniShlomi

Improved treatment
Improved understanding

This chapter provides a comprehensive overview of Chiari type 1 malformation (CIM) and syringomyelia (SM), highlighting existing controversies and future directions for clinical research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Resolution of Large Cervico-Thoracic Syringomyelia Following Treatment of Thyrotoxicosis: A Case Report.

Author: CravenClaudia L, MullinsSophie, Pradini-SantosLaura, WatkinsLaurence D

Syrinx resolution

This case report describes syrinx resolution following treatment of thyrotoxicosis in a patient with Chiari 1 malformation, suggesting a potential link between hyperdynamic circulation and syrinx formation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

7.

A novel scoring system for assessing adult syringomyelia associated with CM I treatment outcomes.

Author: GuanJian, YuanChenghua, YaoQingyu, DuYueqi, FangZeyu, ZhangLei, JiaShanhang, ZhangCan, LiuZhenlei, WangKai, DuanWanru, WangZuowei, WangXingwen, WuHao, ChenZan, JianFengzeng

Syringomyelia assessment

This study evaluates a novel scoring system (SOS-XW) for assessing surgical outcomes in the treatment of syringomyelia (SM) associated with Chiari malformation type I (CM I).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Post-traumatic syringomyelia resolution following surgical treatment: the moniliform syrinx with a better prognosis.

Author: LuChunli, GuanJian, DingChenyuan, WangXingwen, WangZuowei, ChenZan, WuHao, JianFengzeng

Endogenous repair
PTS

The study investigates whether there might be an 'early syringomyelia state' after spinal cord injury, potentially leading to better outcomes.

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Spinal cord stimulator for the treatment of central neuropathic pain secondary to cervical syringomyelia: illustrative case.

Author: SchatmeyerBryan A, DodinRakan, KinsmanMichael, GarciaDavid

CNP treatment

Central neuropathic pain (CNP) of the cervical and/or thoracic spinal cord can be challenging to treat. While spinal cord stimulation is often used for adults, it is rarely used in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Spinal arachnoiditis and syringomyelia: Review of literature with emphasis on postinfectious inflammation and treatment.

Author: NadeemSyed Faisal, BaigAhmer Nasir, TariqQurat Ul Ain, ShamimMuhammad Shahzad

Arachnoiditis complications
Syringomyelia

Arachnoiditis is a rare and debilitating disease causing chronic inflammation of the arachnoid mater and subarachnoid space. It can result in a variety of symptoms and complications, including syringomyelia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Magendie's foramen debridement and catheterisation for the treatment of syringomyelia due to diffuse craniocervical junction arachnoiditis. A case report and technical note.

Author: Champeaux-DepondCharles, FroelichSébastien, ParkerFabrice, BirladeanuAndréi

Arachnoiditis treatment
Hydrocephalus
Syrinx

This case report describes a patient who developed lumbar spinal arachnoiditis after epidural anesthesia for childbirth, leading to lower limb impairment, hydrocephalus, and ultimately, tetraparesis due to a syrinx. The patient underwent a combined surgical procedure that included an open fourth ventriculostomy and catheter insertion to address all problems simultaneously, with positive results.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature.

Author: AhnHyunjun, LeeSang Yeon, JungWon-Ju, LeeKye-Ho

Recurrence
Side effects
Surgical failure

Syringomyelia is a disease of the spinal cord that can cause pain, numbness, and weakness. While surgery is currently the only treatment, it is not always effective and can have side effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

16.

Socioeconomic and demographic factors in the diagnosis and treatment of Chiari malformation type I and syringomyelia.

Author: AkbariSyed Hassan A, RizviAsad A, CreveCoeurTravis S, HanRowland H, GreenbergJacob K, TornerJames, BrockmeyerDouglas L, WellonsJohn C, LeonardJeffrey R, ManganoFrancesco T, JohnstonJames M, ShahManish N, IskandarBermans J, AhmedRaheel, TuiteGerald F, KaufmanBruce A, DanielsDavid J, JacksonEric M, GrantGerald A, PowersAlexander K, CoutureDaniel E, AdelsonP David, AldenTord D, AldanaPhilipp R, AndersonRichard C E, SeldenNathan R, BierbrauerKarin, BoydstonWilliam, ChernJoshua J, WhiteheadWilliam E, DauserRobert C, EllenbogenRichard G, OjemannJeffrey G, FuchsHerbert E, GuillaumeDaniel J, HankinsonTodd C, O'NeillBrent R, IantoscaMark, OakesW Jerry, KeatingRobert F, KlimoPaul, MuhlbauerMichael S, McCombJ Gordon, MenezesArnold H, KhanNickalus R, NiaziToba N, RaghebJohn, ShannonChevis N, SmithJodi L, AckermanLaurie L, JeaAndrew H, MaherCormac O, NarayanPrithvi, AlbertGregory W, StoneScellig S D, BairdLissa C, GrossNaina L, DurhamSusan R, GreeneStephanie, McKinstryRobert C, ShimonyJoshua S, StrahleJennifer M, SmythMatthew D, DaceyRalph G, ParkTae Sung, LimbrickDavid D

Improved access
Improved care

This study examined the social determinants that influence access and outcomes for pediatric neurosurgical care for patients with Chiari malformation type I (CM-I) and syringomyelia (SM). Non-White patients were older at diagnosis and more likely to be treated at low-volume centers, leading to longer operative times, higher estimated blood loss, and a longer hospital stay. Race is associated with age and timing of diagnosis, highlighting socioeconomic and demographic barriers to care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Brace treatment for scoliosis secondary to chiari malformation type 1 or syringomyelia without neurosurgical intervention: A matched comparison with idiopathic scoliosis.

Author: ZhangTianyuan, BaoHongda, ZhangXin, ShuShibin, LiuZhen, SunXu, QiuYong, ZhuZezhang

Scoliosis prevention
Scoliosis surgery prevention
Curve progression

Brace treatment is effective for Chiari malformation type 1 (CM-1) or syringomyelia associated scoliosis without neurosurgical intervention. Compared to idiopathic scoliosis, patients with CMS-associated scoliosis had a higher rate of curve progression, but similar prevention for scoliosis surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Diagnosis and treatment of Chiari malformation and syringomyelia in adults: international consensus document.

Author: CiaramitaroPalma, MassimiLuca, BertuccioAlessandro, SolariAlessandra, FarinottiMariangela, PerettaPaola, SalettiVeronica, ChiappariniLuisa, BarbaneraAndrea, GarbossaDiego, BolognesePaolo, BrodbeltAndrew, CeladaCarlo, CocitoDario, CuroneMarcella, DevigiliGrazia, ErbettaAlessandra, FerrarisMarilena, FurlanettoMarika, GilantonMado, JalloGeorge, KaradjovaMarieta, KlekampJorg, MassaroFulvio, MorarSylvia, ParkerFabrice, PerriniPaolo, PocaMaria Antonia, SahuquilloJuan, StoodleyMarcus, TalamontiGiuseppe, TriulziFabio, ValentiniMaria Consuelo, VisocchiMassimiliano, ValentiniLaura,

Chiari malformation
Syringomyelia

International experts have reached a consensus on diagnostic criteria and treatment guidelines for Chiari 1 malformation and syringomyelia in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

[Treatment of syringomyelia in patients with arachnopathy within craniovertebral junction].

Author: ZuevA A, KostenkoG V

Arachnoiditis
Syringomyelia

This paper describes a rare case of adhesive arachnoiditis developing within the occipital cistern, impairing cerebrospinal fluid flow and leading to syringomyelia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

20.

Is C1-C2 Reduction and Fixation A Good Choice in the Treatment of Recurrent Chiari-Like Symptoms With Syringomyelia?

Author: İştemenİsmail, HarmanFerhat, ArslanAli, OlgunerSemih Kıvanç, AçıkVedat, ÖktenAli İhsan, ArslanBarış, GezercanYurdal

CM treatment

For patients with Chiari malformation (CM) who have undergone failed foramen magnum decompression (FMD), atlantoaxial fusion may be an effective second-line treatment option. The study suggests a treatment algorithm for CM with syringomyelia, prioritizing atlantoaxial fusion in cases of FMD failure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Treatment of posttraumatic syringomyelia: evidence from a systematic review.

Author: KleindienstAndrea, LautFrancisco Marin, RoeckeleinVerena, BuchfelderMichael, Dodoo-SchittkoFrank

PTS treatment

After a spinal cord injury (SCI), a condition called posttraumatic syringomyelia (PTS) is often found on MRI scans. While surgery has been the preferred treatment for decades, there's no clear agreement on the best approach. This review examines the different treatments for PTS, their effectiveness, and potential risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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