Side Effects of tafenoquine: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Main Research Findings

Tafenoquine is a new drug approved by the FDA in 2018 for the treatment of Plasmodium vivax malaria infection and malaria prophylaxis. 4 Tafenoquine also shows promise as a treatment for Babesia infection, a parasitic disease that can be fatal in people with weakened immune systems. 4 The drug is considered a promising antimalarial prophylactic drug. 7

Reasons for Side Effects

Tafenoquine side effects may be caused by reactive oxygen species (ROS) generated during drug metabolism in the body. 4 ROS can damage cells and cause various side effects.

Common Side Effects

Gastrointestinal

Tafenoquine can cause gastrointestinal side effects. 7

Metabolic

Tafenoquine can cause hyperkalemia. 4

Countermeasures for Side Effects

Hyperkalemia

Appropriate measures, such as dietary management and medication, are necessary to reduce the risk of hyperkalemia caused by tafenoquine. 4

Comparison Among Studies

Commonalities

Many studies have shown that tafenoquine is effective in treating parasitic infections such as Plasmodium vivax and Babesia.

Differences

The research findings on the side effects of tafenoquine vary depending on the research methods and subjects.

Precautions for Real-Life Applications

Tafenoquine is an effective treatment, but it also carries the risk of side effects. Therefore, it is important to use it under the guidance of a physician.

Limitations of Current Research

Research on the side effects of tafenoquine is not yet sufficient. Further research is needed.

Future Research Directions

It is necessary to elucidate the mechanism of tafenoquine side effects and research methods to reduce the risk of side effects.

Conclusion

Tafenoquine has been shown to be effective in treating malaria and Babesia infections. However, there is also a risk of side effects, so it is important to use it under the guidance of a physician.

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
2
0
0
2
8
1.

Pilot study evaluating preference for 3-mg versus 6-mg subcutaneous sumatriptan.

Author: LandyStephen H, McGinnisJudy E, McDonaldSusan A

Improved migraine tolerability
Reduced migraine frequency
Reduced migraine pain
Side effects

A lower dose of subcutaneous sumatriptan (3 mg) was preferred by 80% of patients compared to the standard dose (6 mg) for treatment of migraine attacks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Tafenoquine for malaria prophylaxis in adults: An integrated safety analysis.

Author: Novitt-MorenoAnne, RansomJanet, DowGeoffrey, SmithBryan, ReadLisa Thomas, TooveyStephen

Malaria prophylaxis

This analysis presents an integrated safety assessment of the Tafenoquine Anticipated Clinical Regimen (Tafenoquine ACR) from five clinical trials. Tafenoquine is a new prophylactic antimalarial drug.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives.

Author: ShirakiHiroaki, KozarMichael P, MelendezVictor, HudsonThomas H, OhrtColin, MagillAlan J, LinAi J

Antimalarial activity
Hemolysis

This study explored the antimalarial activity and toxicity of a series of 5-aryl-8-aminoquinoline derivatives, aiming to separate antimalarial effects from hemolytic side effects. Several compounds showed promising antimalarial activity with reduced toxicity compared to existing drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

4.

Tafenoquine Is a Promising Drug Candidate for the Treatment of Babesiosis.

Author: LiuMingming, JiShengwei, KondohDaisuke, GalonEloiza May, LiJixu, TomihariMizuki, YanagawaMasashi, TagawaMichihito, AdachiMami, AsadaMasahito, IgarashiIkuo, IguchiAiko, XuanXuenan

Babesicidal effect
Rapid elimination of infection
Hyperkalemia
Potential fatal recurrence

Tafenoquine, an FDA-approved drug for malaria, showed promising efficacy against Babesia infection in mice and dogs. Tafenoquine rapidly eliminated acute Babesia infections, but repeated administration or combination therapy may be necessary to prevent recurrence in immunocompromised hosts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group.

Author: ThriemerKamala, LeyBenedikt, BobogareAlbino, DysoleyLek, AlamMohammad Shafiul, PasaribuAyodhia P, SattabongkotJetsumon, JambertElodie, DomingoGonzalo J, CommonsRobert, AuburnSarah, MarfurtJutta, DevineAngela, AktaruzzamanMohammad M, SohelNayeem, NamgayRinzin, DrukpaTobgyel, SharmaSurender Nath, SarawatiElvieda, SamadIriani, TheodoraMinerva, NambanyaSimone, OunekhamSonesay, MudinRose Nanti Binti, Da ThakurGarib, MakitaLeo Sora, DerayRaffy, LeeSang-Eun, BoazLeonard, DanansuriyaManjula N, MudiyanselageSantha D, ChinanonwaitNipon, KitchakarnSuravadee, NausienJohnny, NaketEsau, DucThang Ngo, Do ManhHa, HongYoung S, ChengQin, RichardsJack S, KusriastutiRita, SatyagrahaAri, NoviyantiRintis, DingXavier C, KhanWasif Ali, Swe PhruChing, GuodingZhu, QiGao, KanekoAkira, MiottoOlivo, NguitragoolWang, RoobsoongWanlapa, BattleKatherine, HowesRosalind E, Roca-FeltrerArantxa, DuparcStephan, BhowmickIpsita Pal, KenangalemEnny, BibitJo-Anne, BarryAlyssa, SintasathDavid, AbeyasingheRabindra, SibleyCarol H, McCarthyJames, von SeidleinLorenz, BairdJ Kevin, PriceRic N

Malaria Elimination
G6PD Deficiency

This meeting report summarizes the key discussion points from a round table discussion on the programmatic issues hindering the widespread use of primaquine (PQ) for radical cure of Plasmodium vivax malaria. The discussion highlighted the need for robust point-of-care (PoC) glucose-6-phosphate dehydrogenase (G6PD) tests and strategies to improve adherence to PQ regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Malaria chemoprophylaxis: when should we use it and what are the options?

Author: PetersenEskild

Malaria chemoprophylaxis
Side effects

Malaria chemoprophylaxis involves taking medication to prevent malaria infection. The risk of malaria infection varies depending on the location and the standard of living. There are several different drugs used for malaria chemoprophylaxis, with varying levels of effectiveness and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial.

Author: BruecknerR P, LasseterK C, LinE T, SchusterB G

Effective malaria treatment
Long half-life
Low toxicity
Gastrointestinal issues

WR 238605, a new antimalarial drug, is well-tolerated and has a long half-life, making it suitable for further testing as a prophylactic, curative, and eradication agent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

8.

Smart Safety Surveillance (3S): Multi-Country Experience of Implementing the 3S Concepts and Principles.

Author: IessaNoha, Macolic SarinicViola, GhazaryanLilit, RomanovaNaira, AlemuAsnakech, RungapiromnanWatcharee, JiamsuchonPorntip, PokhagulPattreya, CastroJose Luis, Macias Saint-GeronsDiego, GhukasyanGayane, TeferiMengistab, GuptaMadhur, PalShanthi Narayan

Improved pharmacovigilance

The Smart Safety Surveillance (3S) concept recommends countries to invest judiciously in pharmacovigilance, focusing on new priority products, sharing work and resources with other countries, and building national competence for non-delegatable activities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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