Major Research Findings

Tasimelteon has been shown to be effective in treating non-24-hour sleep-wake disorder (non-24) in two multicenter, randomized, double-blind, placebo-controlled phase 3 trials (SET and RESET). 2 . Non-24 is a rare circadian rhythm disorder caused by the inability of light to reset the body’s internal clock, which is common in totally blind individuals. Tasimelteon is a novel dual-melatonin receptor agonist. These studies showed that tasimelteon was effective in circadian entrainment and maintenance compared to placebo, and its safety was also confirmed. 2 .

Tasimelteon is expected to promote the adjustment of the sleep-wake cycle by not only promoting melatonin synthesis but also acting on melatonin receptors. 3 .

Tasimelteon is designed to act on specific targets compared to other drugs. Therefore, it is considered to have a low risk of side effects due to less effects on other receptors and enzymes. 1 .

Reasons for side effects

Tasimelteon works by mimicking the actions of melatonin to adjust the sleep-wake cycle. Therefore, side effects related to melatonin may occur. 3 .

Common Side Effects

Drowsiness

Tasimelteon may cause side effects such as drowsiness. 2 .

Headache

Tasimelteon may cause side effects such as headache. 2 .

Dizziness

Tasimelteon may cause side effects such as dizziness. 2 .

Gastrointestinal Symptoms

Tasimelteon may cause side effects such as gastrointestinal symptoms. 2 .

Psychoneurological Symptoms

Tasimelteon may cause side effects such as psychoneurological symptoms. 2 .

Side Effects Countermeasures

Drowsiness

If you are concerned about drowsiness, consider adjusting the time you take tasimelteon or avoiding driving or operating dangerous machinery. 2 .

Headache

If you are concerned about headache, take over-the-counter pain relievers. 2 .

Dizziness

If you are concerned about dizziness, consider getting up slowly when standing up and taking precautions against falls. 2 .

Gastrointestinal Symptoms

If you are concerned about gastrointestinal symptoms, pay attention to your diet, eat easily digestible foods, and consult your doctor. 2 .

Psychoneurological Symptoms

If you are concerned about psychoneurological symptoms, consult your doctor. 2 .

Comparison of studies

Common points of studies

All three studies showed that tasimelteon was effective in treating non-24-hour sleep-wake disorder. 2 , 3 , 1 .

Differences in studies

The three studies differ in their purposes and designs. 2 , 3 , 1 .

Notes on application to real life

Tasimelteon has been shown to be effective in treating non-24-hour sleep-wake disorder, but it does not work for all patients. 2 .

Tasimelteon may cause side effects such as drowsiness. 2 . Therefore, it is important to take precautions such as refraining from driving or operating dangerous machinery. 2 .

Current research limitations

There is not enough research on tasimelteon yet. 2 , 3 , 1 .

Future research directions

Further research is needed to assess the long-term safety and efficacy of tasimelteon. 2 , 3 , 1 .

Conclusion

Tasimelteon is an effective drug for the treatment of non-24-hour sleep-wake disorder. 2 , 3 , 1 . However, there is a risk of side effects, so please take it as instructed by your doctor. 2 , 3 , 1 .