Side Effects of tavaborole topical: A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Major Research Findings

Tamoxifen and letrozole are effective in preventing breast cancer recurrence. 2 However, these medications can cause side effects. 1 Side effects of tamoxifen include hot flashes and menstrual irregularities. 1 Tamoxifen and letrozole may also cause weight gain. 2 More research is needed to determine how these medications affect thyroid function. 2

Reasons for Side Effects

Tamoxifen and letrozole block estrogen from binding to its receptors, inhibiting its actions. 2 Because these drugs affect how estrogen works in the body, they can cause side effects. 2

Common Side Effects

Hot Flashes

Tamoxifen can cause hot flashes. 1 Hot flashes are characterized by a sudden sensation of heat and sweating. 1 Up to 17% of women taking tamoxifen reported experiencing hot flashes. 1

Menstrual Irregularities

Tamoxifen can cause menstrual irregularities. 1 Menstrual irregularities are characterized by changes in the menstrual cycle. 1 Up to 4% of women taking tamoxifen reported experiencing menstrual irregularities. 1

Weight Gain

Tamoxifen and letrozole can cause weight gain. 2 An average of 1-5 kg weight gain has been observed in women treated for early breast cancer after treatment with chemotherapy/anti-estrogens. 2

Managing Side Effects

Hot Flashes

Hot flashes can be managed through lifestyle changes and medication. 1 Lifestyle changes include quitting smoking, reducing caffeine intake, regular exercise, and wearing loose clothing. 1 Medications include hormone replacement therapy and other drugs. 1

Menstrual Irregularities

Menstrual irregularities can be managed through hormone replacement therapy and other medications. 1

Weight Gain

Weight gain can be managed through diet and exercise. 2 Your doctor can advise on appropriate strategies to manage weight gain. 2

Comparison of Studies

Similarities

Both studies show that tamoxifen can cause side effects. 1 2 Both studies show that tamoxifen and letrozole are effective in preventing breast cancer recurrence. 1 2

Differences

The first study reported that up to 17% of women taking tamoxifen experienced hot flashes. 1 The second study suggests that tamoxifen and letrozole can cause weight gain but further research is needed on their impact on thyroid function. 2

Practical Implications

It’s important to remember that tamoxifen and letrozole can cause side effects if you are taking them. 1 2 Talk to your doctor if you experience side effects. 1 2

Limitations of Current Research

More research is needed to determine how tamoxifen and letrozole affect thyroid function. 2

Future Research Directions

Studies are needed to investigate how tamoxifen and letrozole affect thyroid function. 2

Conclusion

Tamoxifen and letrozole have been shown to be effective in preventing breast cancer recurrence. 2 However, these medications can cause side effects. 1 If you experience any side effects, talk to your doctor. 1 2

Literature analysis of 2 papers
Positive Content
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Negative Content
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Article Type
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1.

Symptoms associated with tamoxifen treatment in postmenopausal women.

Author: LoveR R, CameronL, ConnellB L, LeventhalH

Disease-free survival
Gynecological symptoms
Vasomotor symptoms

Tamoxifen therapy in postmenopausal women with breast cancer was associated with significant perceived symptom 'cost', including vasomotor symptoms and gynecologic symptoms, potentially compromising long-term compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.

Author: MarinaDjordje, RasmussenÅse Krogh, Buch-LarsenKristian, GillbergLinn, AnderssonMichael, SchwarzPeter

BC recurrence
Thyroid function

Tamoxifen and letrozole are anti-oestrogens used to prevent breast cancer recurrence. While their side effects are well-documented, their impact on thyroid function is less clear. This review explores the potential effects of tamoxifen and letrozole on thyroid function and their contribution to weight gain observed in breast cancer patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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