Side Effects of teprotumumab-trbw injection: A Synthesis of Findings from 3 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of teprotumumab-trbw injection: A Synthesis of Findings from 3 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Main Research Findings

The use of antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. 1 . When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). 1 . Anti-estrogen therapy with tamoxifen and letrozole is effective in preventing breast cancer recurrence but can affect thyroid function. 2 . Long-term treatment with levothyroxine for hypothyroidism can cause many side effects. 3 . Herbal medicine treatment can regulate thyroid hormones and prevent side effects. 3 .

Reasons for Side Effects

Antithyroid drugs and anti-estrogen drugs can affect hormone balance in the body, leading to side effects. 1 , 2 . Long-term levothyroxine treatment for hypothyroidism can lead to side effects. 3 .

Common Side Effects

Hepatotoxicity

Hepatotoxicity has been reported as a side effect of antithyroid drugs. 1 .

Cutaneous Reactions

Cutaneous reactions have been reported as a side effect of antithyroid drugs. 1 .

Weight Gain

Weight gain has been reported as a side effect of anti-estrogen drugs such as tamoxifen and letrozole. 2 .

Changes in Thyroid Function

Anti-estrogen drugs such as tamoxifen and letrozole can affect thyroid function. 2 .

Side Effects Management

Hepatotoxicity

If you experience symptoms of hepatotoxicity, consult your doctor. 1 .

Cutaneous Reactions

If you experience symptoms of cutaneous reactions, consult your doctor. 1 .

Weight Gain

If you are concerned about weight gain, consult your doctor. 2 .

Changes in Thyroid Function

If you experience any abnormalities in thyroid function, consult your doctor. 2 .

Comparison of Studies

Commonalities

All three studies examine side effects of drug treatments.

Differences

Study 1 examines the side effects of antithyroid drugs. Study 2 examines the side effects of anti-estrogen drugs. Study 3 examines the treatment of hypothyroidism.

Considerations for Real-Life Application

It is important to discuss the risks of side effects with your doctor when undergoing drug treatment. 1 , 2 . Herbal medicine treatment should also be done in consultation with your doctor. 3 .

Limitations of Current Studies

All three studies focus on specific drugs or treatments. Therefore, it is unclear whether these findings are applicable to other drugs or treatments.

Future Research Directions

Further research is needed on the side effects of various drugs and treatments.

Conclusion

Antithyroid drugs and anti-estrogen drugs are known to cause side effects. 1 , 2 . Long-term levothyroxine treatment for hypothyroidism can lead to side effects. 3 . It is important to discuss the risks of side effects with your doctor when undergoing drug treatment. 1 , 2 . Herbal medicine treatment should also be done in consultation with your doctor. 3 .

Literature analysis of 3 papers
Positive Content
2
Neutral Content
1
Negative Content
0
Article Type
1
0
2
1
3
1.

Hepatotoxicity and cutaneous reactions after antithyroid drug administration.

Author: OtsukaFumiko, NohJaeduk Y, ChinoToshiko, ShimizuTaeko, MukasaKoji, ItoKunihiko, ItoKoichi, TaniyamaMatsuo

Antithyroid drug side effects

This study investigated side effects associated with the first and second antithyroid drugs (ATDs) used in patients. The study highlights the high frequency of side effects associated with thiamazole (MMI) and propylthiouracil (PTU).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.

Author: MarinaDjordje, RasmussenÅse Krogh, Buch-LarsenKristian, GillbergLinn, AnderssonMichael, SchwarzPeter

BC recurrence
Thyroid function

Tamoxifen and letrozole are anti-oestrogens used to prevent breast cancer recurrence. While their side effects are well-documented, their impact on thyroid function is less clear. This review explores the potential effects of tamoxifen and letrozole on thyroid function and their contribution to weight gain observed in breast cancer patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled Trials.

Author: JavidiNajmeh, KhorasaniZahra Mazloum, SalariRoshanak, NiroumandShabnam, YousefiMahdi

Hypothyroidism treatment

Hypothyroidism is a common condition that can cause health problems, especially in older adults. While medications are used to treat hypothyroidism, they can have side effects. Herbal remedies are being explored as a potential treatment for hypothyroidism that can regulate thyroid hormones and reduce side effects.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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