Effective treatment of trigeminal neuralgia: A Synthesis of Findings from 60 Studies

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Original Abstract of the Article

Major Research Findings

Trigeminal neuralgia (TN) is a common condition characterized by episodes of intense pain in one or more branches of the trigeminal nerve. 9 TN can be debilitating and severely impact the quality of life of those affected. 38 The exact cause of TN is unknown, but it is believed to be related to blood vessels pressing on the trigeminal nerve. 8 The incidence of TN increases with age, making it a common concern for neurosurgeons. 9 There are a variety of treatments available for TN, including medication, nerve blocks, and surgery. 4 The most common treatment is medication, but it is not always effective, and side effects can occur. 19 Microvascular decompression (MVD) is considered the most effective surgical treatment for TN. 8 It involves separating the blood vessels from the trigeminal nerve to relieve pressure. 8 However, MVD carries risks, including cerebellar hematoma, cranial nerve injury, stroke, and death, particularly in elderly patients. 9 Other less invasive treatments like gamma knife radiosurgery (GKRS) and radiofrequency thermocoagulation (RF) have been investigated as alternatives to traditional surgery. 25 GKRS, in particular, has shown promise with good pain control and low complication rates, but long-term effectiveness still needs to be studied. 25

Treatment Summary

The most common treatment for TN is medication, with carbamazepine being the first-line drug. 12 When medication fails or has intolerable side effects, other treatment options such as nerve blocks, microvascular decompression (MVD), gamma knife radiosurgery (GKRS), radiofrequency thermocoagulation (RF), botulinum toxin type A (BoTN-A), and even acupuncture can be considered. 19 10 20 24 37 25 MVD is considered the most effective surgical treatment, providing long-term pain relief in many cases. 8 However, it involves a surgical procedure and carries inherent risks. 9 GKRS is a less invasive alternative to traditional surgery, showing promise with good pain control and low complication rates. 25 However, its long-term effectiveness is still under investigation. 25

Benefits and Risks

Benefit Summary

Different TN treatment options offer varying benefits, depending on the individual patient and their condition. 4 Medication is generally considered safe with a low risk of complications, but its effectiveness can vary, and side effects can occur. 19 MVD can provide long-lasting pain relief in many cases, potentially offering a lasting solution. 8 GKRS is a less invasive alternative to surgery with potential for good pain control and lower complication rates, but its long-term effectiveness needs further investigation. 25

Risk Summary

All TN treatment options carry risks, though the severity and frequency vary. Medication can cause side effects, ranging from mild to severe. 19 MVD is a surgical procedure with inherent risks, particularly in elderly patients. 9 GKRS, while less invasive, still carries some risks, and its long-term safety and effectiveness require further study. 25

Comparison of Research

Commonalities of Research

A number of studies have highlighted the importance of considering both the benefits and risks associated with different TN treatment options. 4 25 8 9 While medication is generally considered safe and less invasive, its effectiveness can vary, and side effects can occur. 19 MVD is considered the most effective surgical treatment, but it carries risks. 9 GKRS presents a less invasive alternative, but its long-term effectiveness needs further investigation. 25

Differences in Research

Some studies provide different perspectives on the effectiveness of specific treatments, including MVD and GKRS. 25 8 While some studies emphasize the effectiveness of MVD for long-term pain relief, others highlight the promising results of GKRS with good pain control and lower complication rates. 25 8 Furthermore, some studies highlight the effectiveness of nerve blocks in certain cases where medication fails, while others indicate that their effects may be temporary. 38 1

Consistency and Contradictions in Results

While a considerable amount of research has been conducted on TN treatment options, inconsistencies and contradictions exist in the results. 25 4 8 9 For instance, some studies highlight the success rates of MVD, while others emphasize the potential of GKRS. 25 8 Additionally, the effectiveness of nerve blocks can vary, with some studies showing effectiveness in specific situations, while others suggest that their effects might be temporary. 38 1 These discrepancies could be attributed to factors like differences in research designs, sample sizes, patient populations, and the specific treatment approaches employed. 4 25

Application in Real Life: Things to Keep in Mind

While research offers valuable insights into TN treatment options, the ideal treatment for a specific individual depends on their unique situation. 4 25 Factors like the severity of symptoms, the patient’s medical history, age, and personal preferences can influence the best course of action. 4 25 Therefore, consulting a healthcare professional is crucial to determine the most suitable treatment approach for each individual. 4 25

Limitations of Current Research

Current research on TN treatment options has limitations. 4 25 Many studies have been conducted with relatively small sample sizes, limiting the generalizability of the findings. 4 25 Moreover, differences in research designs, patient populations, and specific treatment approaches make direct comparisons between studies challenging. 4 25 Additionally, long-term effectiveness and safety data for certain treatment options, especially less invasive approaches like GKRS, are limited. 4 25

Future Research Directions

Further research on TN treatment options is crucial to address current limitations and better understand the long-term impact of various treatments. 4 25 Large-scale, well-designed studies comparing different treatment approaches are needed to establish the most effective and safe options. 4 25 Long-term follow-up studies are essential to evaluate the durability of pain relief and potential long-term side effects of various treatments, particularly for less invasive options like GKRS. 4 25 Furthermore, research should focus on developing personalized treatment plans tailored to individual patient needs and characteristics. 4 25

Conclusion

The research on TN treatment options highlights the importance of a personalized approach, considering individual patient factors and the benefits and risks associated with different treatments. 4 25 While medication is the most common treatment, it might not always be effective, and side effects can occur. 19 MVD is considered the most effective surgical treatment but carries risks. 9 GKRS shows promise as a less invasive alternative with good pain control and low complication rates, but its long-term effectiveness needs further investigation. 25 Consult a healthcare professional to determine the best treatment for your specific situation. 4 25 Continued research is crucial to refine our understanding of TN and develop the most effective and safe treatments for individuals suffering from this debilitating condition. 4 25

Treatment List

Medication, Nerve Blocks, Microvascular Decompression (MVD), Gamma Knife Radiosurgery (GKRS), Radiofrequency Thermocoagulation (RF), Botulinum toxin type A (BoTN-A), Acupuncture.

Keywords
Benefit Keywords
ITN treatment
1
Pain relief
2
Trigeminal neuralgia treatment
3
Neuropathic trigeminal pain treatment
4
Improved trigeminal neuralgia treatment
5
TN treatment
6
Improved trigeminal neuralgia
7
TN treatment
8
Treatment for TN
9
Fewer adverse effects
Similar efficacy to CBZ
10
Treatment of trigeminal neuralgia
11
Improved trigeminal neuralgia treatment
12
Treatment of drug-resistant TN in MS patients
13
Pain relief
14
TN treatment
15
Trigeminal neuralgia treatment
16
Microvascular decompression
17
TN treatment
18
Lidocaine block for CTN
19
Alternative treatment
Pain reduction
20
Pain relief
Safe procedure
21
Efficacy for TN and PHN
22
Medication avoidance
Pain control
23
Improved outcomes
Reduced pain
24
Good pain control
Low complication rates
25
TN treatment
26
TN/MS treatment
27
TN treatment comparison
28
Trigeminal neuralgia treatment
29
Improved quality of life
30
Microvascular decompression
Trigeminal neuralgia treatment
31
Improved MRTN treatment
32
Trigeminal neuralgia treatment
33
GN treatment
34
PRF
TN treatment
35
RFT
Trigeminal neuralgia treatment
36
Improved TN treatment
37
Fast pain relief
38
Trigeminal postherpetic neuralgia treatment
39
Botulinum toxin type A
TN treatment
40
Improved RTN treatment
41
TN pain control
42
TN treatment
43
Photobiomodulation for trigeminal neuralgia
44
TN treatment
45
Radiofrequency thermocoagulation
46
TN treatment
47
TN treatment
48
Repeat MVD for TN
49
Comfortable treatment
50
TN Treatment
51
Trigeminal neuralgia treatment
52
Pain relief
Reduced recurrence
53
Pain relief
54
MVD and vessel transposition for TGN
55
TRINCOS for TN
56
Trigeminal neuralgia treatment
57
ITN treatment
58
Treatment for PTN
59
Pediatric TN treatment
60
Risk Keywords
Numbness
Paresthesia
2
Trigeminal neuralgia
5
Surgery risk
6
Cerebellar hematoma
Cranial nerve injury
Death
Stroke
9
Trigeminal neuralgia
17
Unclear bias
20
Facial dysesthesia
Hearing loss
Recurrence
23
Pain
30
Neurovascular conflict
31
Complications
36
bothersome numbness
42
Pharmacotherapy side effects
Surgery side effects
44
Trigeminal neuralgia
46
Adverse Reactions
Recurrence
51
Complications
52
Facial numbness
53
Side effects
54
Literature analysis of 60 papers
Positive Content
59
Neutral Content
1
Negative Content
0
Article Type
16
21
37
22
59
1.

Peripheral streptomycin/lidocaine injections versus lidocaine alone in the treatment of idiopathic trigeminal neuralgia. A double blind controlled trial.

Author: StajcićZ, JuniperR P, TodorovićL

ITN treatment

This study compared the effectiveness of injections with a combination of streptomycin and lidocaine to lidocaine alone in treating trigeminal neuralgia (a type of nerve pain) in 17 patients. Both treatments led to initial pain relief, but the effects were temporary. While the combination therapy showed slightly faster initial improvements, long-term relief was similar for both treatments. This suggests that while both treatments may provide temporary relief, they are not a long-term solution for trigeminal neuralgia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Does increased nerve length within the treatment volume improve trigeminal neuralgia radiosurgery? A prospective double-blind, randomized study.

Author: FlickingerJ C, PollockB E, KondziolkaD, PhuongL K, FooteR L, StaffordS L, LunsfordL D

Pain relief
Numbness
Paresthesia

Increasing the treatment volume to include a longer nerve length for trigeminal neuralgia radiosurgery did not improve pain relief but may increase complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Evaluation of surgical procedures for trigeminal neuralgia.

Author: OngK S, KengS B

Trigeminal neuralgia treatment

Trigeminal neuralgia is a painful condition that is difficult to treat. This review examines current surgical procedures used for trigeminal neuralgia, comparing their effectiveness and considering the pros and cons of surgery for this condition. The review also compares surgery with other treatment options for trigeminal neuralgia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Management issues of neuropathic trigeminal pain from a medical perspective.

Author: WatsonC Peter N

Neuropathic trigeminal pain treatment

This review looks at medications used to treat neuropathic trigeminal pain, a type of nerve pain in the face. While several studies were reviewed, many were not randomized or controlled, making it difficult to draw firm conclusions. Trigeminal neuralgia, a specific type of this pain, responds poorly to common medications for other nerve pains. Treatments for postherpetic neuralgia (pain after shingles) are similar to those used for other types of trigeminal nerve pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

[Clinical observation on acupoint injection of VitB12 for treatment of trigeminal neuralgia].

Author: ZhouChang-shan, KongDe-qing, HanZheng-yong

Improved trigeminal neuralgia treatment
Trigeminal neuralgia

This study compares the effectiveness of injecting vitamin B12 into acupuncture points (treatment group) versus taking carbamazepine by mouth (control group) for trigeminal neuralgia. The results were assessed after three rounds of treatment.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

6.

Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies.

Author: GronsethG, CruccuG, AlksneJ, ArgoffC, BraininM, BurchielK, NurmikkoT, ZakrzewskaJ M

TN treatment
Surgery risk

Routine neuroimaging can identify a cause of trigeminal neuralgia (TN) in up to 15% of patients. Carbamazepine or oxcarbazepine are effective treatments for pain control. For patients with TN refractory to medical therapy, Gasserian ganglion percutaneous techniques, gamma knife, and microvascular decompression may be considered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

[Clinical observation on three-combination needling method for treatment of primary trigeminal neuralgia].

Author: PengYi-Yu, HuangYi-Sheng, ZhangSu-Lan, YeXiu-Ying, XiongZhen-Rong, CaoJie

Improved trigeminal neuralgia

The three-combination needling method, which combines acupuncture, acupoint-injection, and fire-needle therapy, showed a higher total effective rate (93.5%) and cured rate (60.9%) compared to acupuncture and acupoint-injection (65.0% and 22.5%) for primary trigeminal neuralgia.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

8.

Microvascular decompression as a surgical management for trigeminal neuralgia: a critical review of the literature.

Author: KabatasSerdar, AlbayrakS Baki, CanseverTufan, HepgulKemal T

TN treatment

Trigeminal neuralgia (TN) is a common condition causing intense, stabbing pain in the face. It is often caused by a blood vessel pressing on the trigeminal nerve. Microvascular decompression (MVD) is the preferred surgery for TN that doesn't respond to medication. MVD has been shown to relieve pain even in people without visible pressure on the nerve and provides the highest long-term satisfaction with the lowest risk of pain returning. This review summarizes research and personal experience on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Microvascular decompression for elderly patients with trigeminal neuralgia: a prospective study and systematic review with meta-analysis.

Author: SekulaRaymond F, FredericksonAndrew M, JannettaPeter J, QuigleyMatthew R, AzizKhaled M, ArnoneGregory D

Treatment for TN
Cerebellar hematoma
Cranial nerve injury
Death
Stroke

This prospective study and systematic review with meta-analysis investigated the safety and effectiveness of microvascular decompression (MVD) in elderly patients with trigeminal neuralgia (TN).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

A systematic review on acupuncture for trigeminal neuralgia.

Author: LiuHua, LiHong, XuMin, ChungKa-Fai, ZhangShi Ping

Fewer adverse effects
Similar efficacy to CBZ

Acupuncture showed similar efficacy to carbamazepine in treating trigeminal neuralgia (TN) with fewer adverse effects, but the evidence is weak due to low methodological quality. Further research is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Neurosurgical interventions for the treatment of classical trigeminal neuralgia.

Author: ZakrzewskaJoanna M, AkramHarith

Treatment of trigeminal neuralgia

Surgery is used for trigeminal neuralgia when medication is ineffective. Surgical approaches can be either ablative (destructive) or non-ablative, and are performed at different locations: near the nerve, at the Gasserian ganglion, or inside the skull.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis.

Author: WangQiang-Ping, BaiMin

Improved trigeminal neuralgia treatment

This study discusses carbamazepine as the primary treatment for trigeminal neuralgia, acknowledging its effectiveness in 70-80% of patients but also highlighting the potential for side effects that may lead to treatment discontinuation. The study examines alternative treatments like oxcarbazepine, baclofen, and topiramate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

What is the best treatment of drug-resistant trigeminal neuralgia in patients affected by multiple sclerosis? A literature analysis of surgical procedures.

Author: MontanoNicola, PapacciFabio, CioniBeatrice, Di BonaventuraRina, MeglioMario

Treatment of drug-resistant TN in MS patients

Trigeminal neuralgia (TN) that doesn't respond to medication can be a challenge for people with multiple sclerosis (MS). While different surgical procedures have been used to treat this condition, there's no clear consensus on the best approach. This study aims to assess the outcomes of various surgical procedures for TN in people with MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Botulinum toxin-type A: could it be an effective treatment option in intractable trigeminal neuralgia?

Author: ShehataHatem S, El-TamawyMohamed S, ShalabyNevin M, RamzyGihan

Pain relief

Botulinum toxin type A (BTX-A) has demonstrated analgesic effects independent of its muscle tone-reducing action, potentially by modulating neurogenic inflammatory mediators and controlling neurotransmitter release in sensory and autonomic nerve terminals. This study investigates the efficacy, safety, and tolerability of BTX-A for treating intractable idiopathic trigeminal neuralgia (TN).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Novel design for a phase IIa placebo-controlled, double-blind randomized withdrawal study to evaluate the safety and efficacy of CNV1014802 in patients with trigeminal neuralgia.

Author: ZakrzewskaJoanna M, PalmerJoanne, EttlinDominik A, ObermannMark, GiblinGerard M P, MorissetValerie, TateSimon, GunnKevin

TN treatment

Trigeminal neuralgia is a rare but severe facial pain condition. While medications like carbamazepine are currently used, they often have side effects and don't fully control pain. This study will evaluate a new medication, CNV1014802, for treating trigeminal neuralgia. Due to the severity of the condition, a standard comparison with a placebo or existing medication is not ethical, so the study will focus on assessing the new drug's effectiveness.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Non-antiepileptic drugs for trigeminal neuralgia.

Author: ZhangJingjing, YangMi, ZhouMuke, HeLi, ChenNing, ZakrzewskaJoanna M

Trigeminal neuralgia treatment

Trigeminal neuralgia is a condition that causes sudden, severe, stabbing pain in the face. Anti-epileptic medications are the standard treatment. While other medications have also been used since the 1970s, this review updates information on the use of non-antiepileptic drugs for trigeminal neuralgia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Effectiveness and safety of microvascular decompression surgery for treatment of trigeminal neuralgia: a systematic review.

Author: XiaLei, ZhongJun, ZhuJin, WangYong-Nan, DouNing-Ning, LiuMing-Xing, VisocchiMassimiliano, LiShi-Ting

Microvascular decompression
Trigeminal neuralgia

This systematic review examines the effectiveness and safety of microvascular decompression for treating trigeminal neuralgia. Microvascular decompression is a surgical procedure that aims to relieve pressure on the trigeminal nerve. The review analyzes data from multiple studies to assess the procedure's success rate and potential complications. The study suggests that microvascular decompression is an effective treatment for trigeminal neuralgia, but careful attention to surgical technique is essential to minimize risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial.

Author: ZhangHaifeng, LianYajun, MaYunqing, ChenYuan, HeCaihong, XieNanchang, WuChuanjie

TN treatment

Trigeminal neuralgia causes sudden, severe, stabbing pain in the face. While medication is the first treatment, surgery or other procedures to block the nerve are options if medication is ineffective or causes side effects. In addition to these methods, injections of Botulinum Toxin Type A (BTX-A) into the skin or mucous membranes have been used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Combination of pharmacotherapy and lidocaine analgesic block of the peripheral trigeminal branches for trigeminal neuralgia: a pilot study.

Author: Di StaniFabrizio, OjangoChristine, DugoniDemo, Di LorenzoLuigi, MasalaSalvatore, DelfiniRoberto, BrutiGianluca, SimonettiGiovanni, PiovesanElcio Juliato, RuggeriAndrea Gennaro

Lidocaine block for CTN

This study examines the therapeutic effect of combining pharmacotherapy with lidocaine block for treating classical trigeminal neuralgia (CTN). The research finds that combining these approaches may significantly reduce pain episodes and improve overall symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses.

Author: ShackletonThomas, RamSaravanan, BlackMisty, RyderJon, ClarkGlenn T, EncisoReyes

Alternative treatment
Pain reduction
Unclear bias

Botulinum toxin type A might be an effective treatment for trigeminal neuralgia and postherpetic neuralgia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Calcitonin as an Additive to Local Anesthetic and Steroid Injection Using a Modified Coronoid Approach in Trigeminal Neuralgia.

Author: ElsheikhNabil Ail, AmrYasser M

Pain relief
Safe procedure

Calcitonin may be a useful additive to local anesthetic and steroid in management of trigeminal neuralgia. A modified coronoid approach for maxillary and mandibular nerve is simple, free of radiation, safe, and may be an effective percutaneous procedure in trigeminal neuralgia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

BoTN-A: The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses.

Author:

Efficacy for TN and PHN

This study reviewed evidence supporting the use of botulinum toxin for treating trigeminal neuralgia and postherpetic neuralgia. The review concludes that there is moderate evidence for the effectiveness of this treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Meta-Analysis on Safety and Efficacy of Microsurgical and Radiosurgical Treatment of Trigeminal Neuralgia.

Author: GubianArthur, RosahlSteffen K

Medication avoidance
Pain control
Facial dysesthesia
Hearing loss
Recurrence

This systematic review compared the evidence regarding safety and efficiency of microvascular decompression (MVD) and radiosurgical treatment (RS) for classic trigeminal neuralgia. The review found that MVD was associated with higher initial success rates and lower recurrence rates than RS, but that RS may be a suitable option for patients with higher surgical risk. This suggests that both MVD and RS are valid treatment options for trigeminal neuralgia, and that the choice of treatment should be individualized based on patient factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Interventions for Refractory Trigeminal Neuralgia: A Bayesian Mixed Treatment Comparison Network Meta-Analysis of Randomized Controlled Clinical Trials.

Author: SridharanKannan, SivaramakrishnanGowri

Improved outcomes
Reduced pain

Sumatriptan and combined continuous and pulsed radiofrequency thermocoagulation had significant effects in reducing pain in patients with refractory trigeminal neuralgia (TN). The quality of evidence was graded as very low for all except botulinum toxin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia.

Author: SpinaAlfio, BoariNicola, GagliardiFilippo, BailoMichele, MorselliCarlotta, IannacconeSandro, MortiniPietro

Good pain control
Low complication rates

This systematic review examines the use of gamma knife radiosurgery (GKRS) for treating glossopharyngeal neuralgia (GPN). The study explores the effectiveness and safety of this treatment compared to other approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Efficacy of 8 Different Drug Treatments for Patients With Trigeminal Neuralgia: A Network Meta-analysis.

Author: YangFang, LinQiang, DongLihua, GaoXiaohui, ZhangSu'e

TN treatment

Trigeminal neuralgia (TN) is a painful condition that affects older adults. While there are medications to treat TN, the best choice is unclear. This study uses network meta-analysis (NMA) to compare the effectiveness of 8 different medications for TN.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

A Systematic Review of the Management of Trigeminal Neuralgia in Patients with Multiple Sclerosis.

Author: ZakrzewskaJoanna M, WuJianhua, BrathwaiteTricia S-L

TN/MS treatment

People with trigeminal neuralgia (TN) and multiple sclerosis (MS) are often treated with medications or surgery. However, there's not much research to prove that these treatments reduce pain by 50% or significantly improve quality of life. This review aims to evaluate the effectiveness of treatments for TN in people with MS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Comparative efficacy and acceptability of antiepileptic drugs for classical trigeminal neuralgia: a Bayesian network meta-analysis protocol.

Author: QinZongshi, XieShang, MaoZhi, LiuYan, WuJiani, FurukawaToshi A, KwongJoey S W, TianJinhui, LiuZhishun

TN treatment comparison

A systematic review will be conducted to compare the efficacy and acceptability of all currently available antiepileptic drugs for the treatment of classical trigeminal neuralgia (TN).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

29.

Pain-Free Outcomes and Durability of Surgical Intervention for Trigeminal Neuralgia: A Comparison of Gamma Knife and Microvascular Decompression.

Author: MendelsonZachary S, VelagalaJayant R, KohliGurkirat, HeirGary M, MammisAntonios, LiuJames K

Trigeminal neuralgia treatment

This study compares two treatment options for trigeminal neuralgia (TN), a painful condition: microvascular decompression (MVD) and Gamma Knife surgery (GKS). The study aims to determine which procedure is more effective in providing immediate and long-lasting pain relief, and how often the pain returns after treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

The psychosocial impact of orofacial pain in trigeminal neuralgia patients: a systematic review.

Author: MelekL N, DevineM, RentonT

Improved quality of life
Pain

This systematic review determined the psychosocial impact of orofacial pain in patients with trigeminal neuralgia (TN), highlighting the significant impact of refractory pain on quality of life and recommending psychological support within a multidisciplinary team.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

First treatment and retreatment of medically refractive trigeminal neuralgia by stereotactic radiosurgery versus microvascular decompression: a systematic review and Meta-analysis.

Author: LuVictor M, DuvallJulia B, PhanKevin, JonkerBenjamin P

Improved MRTN treatment

This study compared the outcomes of two treatments for trigeminal neuralgia that doesn't respond to medication: stereotactic radiosurgery (SRS) and microvascular decompression (MVD). The study paid particular attention to first-time treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Microvascular decompression versus stereotactic radiosurgery as primary treatment modality for trigeminal neuralgia: A systematic review and meta-analysis of prospective comparative trials.

Author: SharmaRavi, PhalakManoj, KatiyarVaridh, BorkarSachin, KaleShashank S, MahapatraAshok K

Trigeminal neuralgia treatment

A meta-analysis of prospective trials comparing microvascular decompression (MVD) and gamma knife radiosurgery for trigeminal neuralgia found that both procedures were effective, but MVD had a higher rate of complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Nervus intermedius and the surgical management of geniculate neuralgia.

Author: Peris-CeldaMaria, OushySoliman, PerryAvital, GraffeoChristopher S, CarlstromLucas P, ZimmermanRichard S, MeyerFredric B, PollockBruce E, LinkMichael J

GN treatment

Geniculate neuralgia (GN) is a rare and painful condition affecting the face, often mistaken for other conditions like trigeminal neuralgia (TN) or glossopharyngeal neuralgia (GPN) due to overlapping symptoms and the complexity of facial nerves. Diagnosis and treatment can be challenging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Effectiveness and Safety of High-Voltage Pulsed Radiofrequency to Treat Patients with Primary Trigeminal Neuralgia: A Multicenter, Randomized, Double-Blind, Controlled Study Protocol.

Author: JiaYitong, PanYuesong, RenHao, JiNan, LuoFang

PRF
TN treatment

Trigeminal neuralgia (TN) is a very painful condition affecting the face. While medications are often used, people who don't respond well can receive a nerve block. Pulsed radiofrequency (PRF) is a non-invasive pain treatment, but its effectiveness for TN is unclear. A small study showed that a high-voltage PRF treatment was effective for TN, but more research is needed to confirm this, particularly in people who haven't responded to other treatments. The study suggests comparing high-voltage PRF to standard nerve blocks in a controlled trial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Comparative safety and efficacy of percutaneous approaches for the treatment of trigeminal neuralgia: A systematic review and meta-analysis.

Author: TexakalidisPavlos, XenosDimitrios, ToraMuhibullah S, WetzelJeremy S, BoulisNicholas M

Improved TN treatment

This meta-analysis compares the safety and efficacy of glycerol rhizotomy (GR), radiofrequency thermocoagulation (RF), and balloon compression (BC) as percutaneous treatments for trigeminal neuralgia (TN).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

A systematic review of rescue analgesic strategies in acute exacerbations of primary trigeminal neuralgia.

Author: MooreD, ChongM S, ShettyA, ZakrzewskaJ M

Fast pain relief

A systematic review of 17 studies found that local anesthetics (lidocaine), anticonvulsants (phenytoin/fosphenytoin), and serotonin agonists (sumatriptan) may provide fast and safe relief of trigeminal neuralgia (TN) exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

High-Voltage, Long-Duration Pulsed Radiofrequency on Gasserian Ganglion Improves Acute/Subacute Zoster-Related Trigeminal Neuralgia: A Randomized, Double-Blinded, Controlled Trial.

Author: WanChengfu, DongDao-Song, SongTao

Trigeminal postherpetic neuralgia treatment

Trigeminal postherpetic neuralgia is a severe, often difficult-to-treat type of nerve pain that can occur after shingles. While many studies have been conducted, the best way to prevent this type of pain from developing is still unknown.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Combined pulsed and thermal radiofrequency versus thermal radiofrequency alone in the treatment of recurrent trigeminal neuralgia after microvascular decompression: A double blinded comparative study.

Author: Abdel-RahmanKhaled A, ElawamyAbdelraheem M, MostafaMohamed F, HasanWaleed S, HerdanRagaa, OsmanNagwa M, IbrahimAbdelrady S, AlyMohamed G, AliAbdelhady S, AbodahabGamal M

Improved RTN treatment

This study evaluates the effect of adding pulsed radiofrequency to radiofrequency thermocoagulation at 60°C compared to radiofrequency thermocoagulation at 70°C alone in treating recurrent trigeminal neuralgia after microvascular decompression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Optimizing Radiosurgery for Trigeminal Neuralgia: Impact of Radiation Dose and Anatomic Target on Patient Outcomes.

Author: WilsonTaylor Anne, KarlssonBengt, HuangLei, RamanathanDinesh, OyoyoUdochukwu, BolingWarren

TN pain control
bothersome numbness

This study found that increasing radiation prescription dose was associated with improved pain control in patients with trigeminal neuralgia (TN) without increasing bothersome numbness. The distal target was also associated with improved pain control, independent of dose. Bothersome numbness was not related to dose or target.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Trigeminal Neuralgia Secondary to Meningiomas and Vestibular Schwannoma Is Improved after Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis.

Author: Peciu-FlorianuIulia, RégisJean, LevivierMarc, DedeciusovaMichaela, ReynsNicolas, TuleascaConstantin

TN treatment

Trigeminal neuralgia (TN), a condition that causes severe facial pain, can be caused by tumors affecting nerves in the face. Stereotactic radiosurgery (SRS), a treatment that uses focused radiation, is used to treat these tumors. This review will examine research on SRS for TN caused by meningiomas and vestibular schwannomas (VS), looking at how often it improves symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Photobiomodulation on trigeminal neuralgia: systematic review.

Author: IbarraAna Melissa Ccopa, Biasotto-GonzalezDaniela Aparecida, KohatsuEdna Yoshiko Ide, de OliveiraSimone Saldanha Ignacio, BussadoriSandra Kalil, TanganeliJoão Paulo Colesanti

Photobiomodulation for trigeminal neuralgia
Pharmacotherapy side effects
Surgery side effects

This systematic review investigates the use of photobiomodulation as an alternative therapy for trigeminal neuralgia, comparing its effectiveness to conventional therapies and TENS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Efficacy of Gamma Knife radiosurgery in the management of multiple sclerosis-related trigeminal neuralgia: a systematic review and meta-analysis.

Author: SpinaAlfio, NoceraGianluca, BoariNicola, IannacconeSandro, MortiniPietro

TN treatment

GKRS is a safe and effective treatment for TN and has been adopted for MS-TN, although with a lower success rate. This study reviewed 12 articles involving 646 patients to analyze the outcome of GKRS for MS-TN. GKRS had an 83% initial pain response rate, which decreased to 47% during follow-up. Length of follow-up was the only factor significantly explaining heterogeneity in the proportion of successful treatments. GKRS remains a valuable option for MS-TN, but its long-term efficacy should be considered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study.

Author: WangTingting, XuSaijun, HeQiuli, TaoJiachun, NiHuadong, ZhuJianjun, LuoGe, FuJie, XieKeyue

Radiofrequency thermocoagulation
Trigeminal neuralgia

A randomized clinical trial of 57 patients with ophthalmic division trigeminal neuralgia found that the transverse puncture method during radiofrequency thermocoagulation through the supraorbital foramen had better efficacy and fewer complications in comparison with the vertical puncture method. The Numeric Rating Scale scores at 6 months, 1 year, and 2 years after the treatment were significantly lower in the transverse puncture group compared to the vertical puncture group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Internal Neurolysis for the Treatment of Trigeminal Neuralgia: A Systematic Review.

Author: SabourinVictor, LavergnePascal, MazzaJacob, HeadJeffrey, Al-SaieghFadi, StefanelliTony, KarsyMichael, EvansJames J

TN treatment

Trigeminal neuralgia (TN) is a painful condition that can be difficult to treat. While surgery is an option, it's not always clear how well it works. This review will examine research on a specific surgical procedure called microvascular decompression with internal neurolysis (IN) for TN.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

A Systematic Review of Repeat Microvascular Decompression for Recurrent or Persistent Trigeminal Neuralgia.

Author: JiaoLiwu, YeHao, LvJibo, XieYong, SunWei, DingGuolin, CuiSimin

Repeat MVD for TN

This systematic review analyzed the literature on the feasibility of repeat microvascular decompression (MVD) for treating recurrent or persistent trigeminal neuralgia (TN) after initial MVD. MVD is a common treatment for TN, but managing recurrent or persistent TN following MVD can be challenging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Cardiovascular response to Gasserian ganglion ablation on trigeminal neuralgia under local anesthesia: a retrospective single-blind case-control study.

Author: ZhaoDingliang, LiJing, MaChao, HuangYing, TaoGaojian

Comfortable treatment

This study assessed the safety and efficacy of lidocaine local anesthesia for trigeminal neuralgia patients undergoing radiofrequency thermocoagulation of the Gasserian ganglion. The study aimed to provide more comfortable treatment for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Efficacy and safety of microvascular decompression versus percutaneous balloon compression in the treatment of trigeminal neuralgia: a systematic review and meta-analysis.

Author: WuJingwei, XiaoYing, ChenBin, ZhangRuizhu, DaiMingming, ZhangYupeng

TN Treatment
Adverse Reactions
Recurrence

This meta-analysis compared the efficacy and safety of microvascular decompression (MVD) and percutaneous balloon compression (PBC) for trigeminal neuralgia (TN). 18 studies with 1,932 patients were included. Both MVD and PBC showed similar overall effectiveness in treating TN. However, MVD resulted in lower recurrence rates and fewer adverse reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Radiofrequency thermoablation of the peripheral branches of trigeminal nerve versus the Gasserian ganglion for treating idiopathic trigeminal neuralgia: A systematic review and meta-analysis.

Author: AbduhamidAhmed S, AlomariMohammed S, GhaddafAbdullah A, MullahAbdullah N, AlsharifAbdullah, AlqrniAli Mohamed, HaiderMohamed

Trigeminal neuralgia treatment
Complications

Trigeminal neuralgia (TN) causes pain in the face. While medication is often used, some people need other treatments. This study will compare two procedures that use heat to treat TN: radiofrequency thermoablation (RFT) of the Gasserian ganglion and the peripheral branches of the trigeminal nerve. The study will look at how well they work and how many complications each procedure has.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Microvascular Decompression Versus Gamma Knife Surgery in Patients with Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis.

Author: AlizadehYavar, HayakHemn, KhoshnevisanAlireza

Pain relief
Reduced recurrence
Facial numbness

Microvascular decompression (MVD) was superior to Gamma Knife surgery (GKS) in terms of pain relief and lower recurrence rates in patients with drug-resistant Trigeminal Neuralgia (TN).

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

54.

Percutaneous Radiofrequency Ablation for Trigeminal Neuralgia Management: A Randomized, Double-Blinded, Sham-Controlled Clinical Trial.

Author: MansanoAndré Marques, FredericoThiago Nouer, ValentinRaquel Elisa B, CarmonaMaria Jose Carvalho, AshmawiHazem Adel

Pain relief
Side effects

Percutaneous trigeminal radiofrequency ablation resulted in statistically and clinically significant greater pain relief than the sham procedure after 1 month of follow-up. This procedure is supported as a treatment for refractory trigeminal neuralgia.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

55.

Contact-free transposition and interposition techniques for trigeminal neuralgia: a systematic review.

Author: UhlChristian, VajkoczyPeter

MVD and vessel transposition for TGN

This review compared the effectiveness of classic microvascular decompression (MVD) techniques (interposition) and more recent transposition techniques for treating trigeminal neuralgia (TGN).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

56.

An international Delphi survey and consensus meeting to define the core outcome set for trigeminal neuralgia clinical trials.

Author: Venda NovaCarolina, Ni RiordainRicheal, BakerSarah R, ZakrzewskaJoanna M

TRINCOS for TN

This study aimed to reach consensus on what outcomes of treatment are important to different trigeminal neuralgia (TN) stakeholders, identifying the TN Core Outcome Set (TRINCOS).

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Open surgery vs. stereotactic radiosurgery for tumour-related trigeminal neuralgia: A systematic review.

Author: NugrohoSetyo Widi, AnindyaYodie, HafifMuhammad, WicaksanaBima Andyan, DesbassariFitrie, SadewoWismaji, PerkasaSayyid Abdil Hakam

Trigeminal neuralgia treatment

Secondary trigeminal neuralgia is facial pain caused by tumors in a specific area of the brain. Treatment options include surgery to remove the tumor or radiation therapy. This study reviews the effectiveness of both approaches to determine the best treatment for this condition.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

58.

Abnormal activation of brain regions in idiopathic trigeminal neuralgia patients by fMRI: An activation likelihood estimation meta-analysis.

Author: YuXin-Ming, LvWen-Ming, LiuXiao-Liang, KangXi-Zhi, ZhangLiang-Wen

ITN treatment

This study analyzes literature on brain areas with abnormal or reduced activation in ITN patients to provide insight into the neuropathological basis of the disease and potential new treatment targets.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

60.

Treatment of pediatric trigeminal neuralgia with microvascular decompression: a case series and systematic review.

Author: GrossenAudrey A, IserCourtney R, LemingAmy B, DesaiVirendra R, ChruscielDeepti G

Pediatric TN treatment

Trigeminal neuralgia (TN), a painful condition that affects the face, is rare in children, affecting fewer than 2% of cases. Children are often treated with the same medications used for adults, but many don't respond well. This review will look at research on TN in children to better understand its diagnosis, treatment, and complications in this population.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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