Effects of valsartan: A Synthesis of Findings from 5 Studies

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Original Abstract of the Article

Major findings of the studies

Valsartan is an angiotensin II receptor blocker that has been shown to be effective in treating hypertension. 4 A study found that high-dose valsartan monotherapy was significantly more effective in lowering blood pressure than conventional doses in patients with mild-to-moderate hypertension. 3 Another study found that valsartan was effective and safe in lowering blood pressure in children with hypertension aged 1 to 5 years and did not have any negative effects on growth and development. 1 A study on the interaction between valsartan and atenolol found that valsartan was effective in combination therapy with a beta-adrenoceptor blocking agent. 2 Another study demonstrated that valsartan in combination with benazepril was effective in treating congestive heart failure.

Benefits and risks

Benefits summary

Valsartan is an effective drug for treating hypertension. 4 It has been shown to be safe and effective in lowering blood pressure in patients of various ages. 3 Valsartan is also effective in combination therapy with other drugs such as atenolol and benazepril. 1 2

Risks summary

Valsartan is generally a safe drug, but it can cause side effects in some patients. 4 Most side effects are mild and temporary. However, there is always a risk of serious side effects, although they are rare. 3 It is important to follow your doctor's instructions and to have regular checkups to monitor for any potential side effects.

Comparison between studies

Commonalities among studies

All of these studies found that valsartan is an effective drug for lowering blood pressure. 4 These studies also suggest that valsartan is generally safe.

Differences among studies

These studies differ in their target patient populations and research methodologies. 4 For example, one study focused on children with hypertension aged 1 to 5 years, 3 while another focused on adult patients. 4 There were also variations in the dosages of valsartan used and the drugs it was combined with in different studies. 1

Consistency and contradictions in the findings

The findings of these studies are generally consistent. Valsartan has been shown to be safe and effective in lowering blood pressure in patients of various ages. 4 However, these studies did not provide definitive conclusions on the optimal dosage of valsartan or the drugs it should be combined with. 3

Notes on application in real-life

While valsartan is an effective drug for treating hypertension, it is not suitable for all patients. 4 It is important to follow your doctor's instructions and to have regular checkups to monitor for any potential side effects. 3

Limitations of current research

All of these studies involved a limited number of patients, which is insufficient to evaluate the long-term effects and safety of valsartan. 4 Additionally, as these studies were conducted on specific patient populations, their findings cannot be generalized to other patient populations. 3

Future research directions

Larger studies are needed to evaluate the long-term effects and safety of valsartan. 4 Further research is also needed to determine the optimal dosage of valsartan and the drugs it should be combined with. 3

Conclusion

Valsartan is an effective drug for treating hypertension. 4 It is safe and effective in lowering blood pressure in patients of various ages. 3 If you are taking valsartan, follow your doctor's instructions and have regular checkups. 3

Literature analysis of 5 papers
Positive Content
5
Neutral Content
0
Negative Content
0
Article Type
4
1
1
1
5
1.

Pharmacokinetic and pharmacodynamic interaction of single doses of valsartan and atenolol.

Author: CzendlikC H, SioufiA, PreiswerkG, HowaldH

Hypertension treatment
Drug interactions

This study investigates the interaction between valsartan (V), an angiotensin II receptor blocker, and atenolol (A), a beta-adrenoceptor blocker, when co-administered for hypertension treatment. The findings suggest that both drugs affect the pharmacokinetics of each other, but the combination does not significantly alter the pharmacodynamic effects on blood pressure, heart rate, or renin activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Effects of benazepril combined with valsartan on congestive heart failure].

Author: YeJian-feng, LiuDong-sheng

Improve heart failure

A study investigated the efficacy of combining benazepril and valsartan in treating congestive heart failure. The combination was effective in improving cardiac function and was well tolerated.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

3.

Efficacy and safety of the Angiotensin receptor blocker valsartan in children with hypertension aged 1 to 5 years.

Author: FlynnJoseph T, MeyersKevin E C, NetoJose Pacheco, de Paula MenesesRejane, ZurowskaAleksandra, BaggaArvind, MattheyseLionel, ShiVictor, GupteJitendra, Solar-YohaySusan, HanGuangyang,

Hypertension treatment
Adverse events

This study evaluated the efficacy and safety of valsartan in 90 children (mean age: 3.2 years) with systolic blood pressure (SBP) above the 95th percentile. Valsartan effectively lowered SBP and diastolic blood pressure compared to placebo, with no negative effects on growth and development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effectiveness and safety of high-dose valsartan monotherapy in hypertension treatment: the ValTop study.

Author: ParatiGianfranco, AsmarRoland, BiloGrzegorz, KandraAlbert, Di GiovanniRobert, MengdenThomas

Hypertension treatment
Adverse events

The ValTop study compared the efficacy and safety of high versus conventional doses of valsartan in patients with mild to moderate hypertension. The study found that high-dose valsartan was safe and effective, providing additional blood pressure reduction compared to the lower dose, regardless of initial response. This suggests that high-dose angiotensin receptor blocker (ARB) monotherapy may be a viable option for hypertension management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Different Doses of Sacubitril/Valsartan Compared with Olmesartan in Patients with Essential Hypertension: A Systematic Review and Meta-Analysis.

Author: AlmarjanAmjaad Ibrahim, AlmarjanSara Abdulaziz, MasoudAhmed Taher

Antihypertensive effects

Sacubitril/valsartan, a drug with neprilysin inhibition and angiotensin receptor-blocking properties, is expected to have strong antihypertensive effects. However, there is limited evidence to compare its safety and efficacy with olmesartan in patients with hypertension.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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