Major Research Findings

Triazolam and lorazepam both showed similar hypnotic effects and were superior to placebo. However, lorazepam was associated with more drowsiness upon awakening and increased sleepiness in the mid-morning and mid-afternoon compared to triazolam or placebo. 1

Reasons for Side Effects

Lorazepam was reported to have more side effects than triazolam. This could be due to its longer duration of action compared to triazolam, leading to lingering drowsiness and dizziness the next day. 1

Common Side Effects

Drowsiness

Patients reported more drowsiness upon awakening and more sleepiness in mid-morning and mid-afternoon after nights on lorazepam than nights on triazolam or placebo. 1

Lightheadedness

Lorazepam was associated with three times more frequent reports of lightheadedness compared to triazolam or placebo. 1

Restlessness

Lorazepam was associated with three times more frequent reports of restlessness compared to triazolam or placebo. 1

Impaired Coordination

Lorazepam was associated with three times more frequent reports of impaired coordination compared to triazolam or placebo. 1

Dizziness

Lorazepam was associated with three times more frequent reports of dizziness compared to triazolam or placebo. 1

Nausea

Lorazepam was associated with three times more frequent reports of nausea compared to triazolam or placebo. 1

Side Effects Management

Drowsiness

Avoid driving or operating machinery if experiencing significant drowsiness. Consider caffeine intake or taking a walk to alleviate drowsiness. 1

Lightheadedness, Impaired Coordination, Dizziness

Avoid driving or operating machinery if experiencing significant lightheadedness, impaired coordination, or dizziness. Use handrails and take extra caution when walking to prevent falls. 1

Comparison Between Studies

Commonalities

Multiple studies have reported that lorazepam is associated with more side effects than triazolam. 1

Differences

There may be variations in the effectiveness of lorazepam and triazolam as hypnotics and the severity of side effects between different studies. 1

Considerations for Real-Life Application

Lorazepam's longer duration of action compared to triazolam can lead to lingering drowsiness and dizziness the next day. Exercise caution when driving or operating machinery, activities that require concentration and alertness. 1

Limitations of Current Research

Research on the side effects of lorazepam and triazolam is still limited. Further studies are necessary. 1

Future Research Directions

Further research on the side effects of lorazepam and triazolam is warranted. Particularly, research on the long-term impact and individual variations in side effect responses is needed. 1

Conclusion

Both lorazepam and triazolam are effective hypnotics, but lorazepam has been associated with more side effects. It is crucial to understand the risks associated with lorazepam and use it safely. 1