Major Research Findings

One study examined the effects of valerian on subjective sedation, field sobriety testing, and driving simulator performance. 2 Valerian, like benzodiazepines, may increase gamma-aminobutyric acid (GABA) modulation in the brain, sharing a similar mechanism of action. 2 Valerian has been used effectively to treat generalized anxiety disorder and insomnia. 2 However, the safety of driving while under the influence of valerian remains unknown despite the risk of drowsiness. 2

Another study investigated the effects of two doses of a valerian preparation on the sleep, cognitive, and psychomotor function of sleep-disturbed older adults. 1 This study found no significant difference between valerian 300mg, valerian 600mg, or placebo on any EEG parameter or psychometric measure. 1 This suggests that valerian may be ineffective as an acute dose for sleep problems. 1 However, valerian is traditionally sedative and widely used. 1 Therefore, more research is required into therapeutic dose, types of valerian preparation, and the optimal period of use for therapeutic effect. 1

Benefits and Risks

Benefits Summary

Valerian has been used effectively to treat generalized anxiety disorder and insomnia. 2

Risks Summary

Valerian, like benzodiazepines, may increase gamma-aminobutyric acid (GABA) modulation in the brain, sharing a similar mechanism of action. 2 The safety of driving while under the influence of valerian remains unknown. 2 Valerian may be ineffective as an acute dose for sleep problems in older adults. 1

Comparison of Studies

Commonalities

Both studies used a double-blind, placebo-controlled trial design to assess the effects of valerian. 2 1 Both studies agree on the potential for valerian to increase GABA modulation in the brain. 2

Differences

The two studies differ in terms of the population studied, the outcomes assessed, and the type of valerian preparation used. 2 1 One study evaluated subjective sedation, field sobriety testing, and driving simulator performance. 2 The other study evaluated sleep-related EEG parameters and psychometric measures. 1

Consistency and Contradictions of Results

The results of these studies are inconsistent. 2 1 One study suggests that valerian might have sedative effects, while the other suggests that valerian may be ineffective as an acute dose for sleep problems. 2 1 Further research is needed to determine whether valerian affects driving safety. 2

Precautions for Real-Life Application

Although valerian is generally considered safe, it's important to be aware of the risk of side effects. 2 Avoid driving or operating machinery if you have taken valerian. 2 Always consult your doctor before using valerian. 2 1

Limitations of Current Research

These studies have limitations, such as limited sample sizes, which may make generalizing the results difficult. 2 1 Additionally, the type and dosage of valerian used varied, making it difficult to compare results. 2 1

Future Research Directions

Further research is needed to evaluate the effects of valerian on driving safety. 2 Additional studies are also needed to identify the optimal dosage, type, and duration of use for valerian. 1

Conclusion

Valerian is generally considered a safe herb, but it's important to exercise caution when driving or operating machinery. 2 Consult your doctor before using valerian. 2 1