Effects of vigabatrin: A Synthesis of Findings from 12 Studies

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Original Abstract of the Article

Major Research Findings

Vigabatrin has shown promise as a new treatment for partial seizures. Several studies have shown that vigabatrin is significantly more effective than placebo in reducing the frequency of partial seizures. 10 , 3 , 1 , 4 , 6 While the dosage of vigabatrin varies between studies, it is generally administered in the range of 2g to 3g per day. Vigabatrin has been found to be well-tolerated and does not cause clinically significant adverse drug effects when added to established anticonvulsant therapy. 10 Side effects such as drowsiness and visual disturbances (diplopia, ataxia, visual abnormalities) have been reported with vigabatrin, but these side effects appear to increase in a dose-dependent manner. 10 It appears that vigabatrin may be a valuable option for the treatment of partial seizures. 10 However, some research suggests that vigabatrin can have a negative impact on cognitive function in some patients. 6

Benefits and Risks

Benefit Summary

Vigabatrin has been shown to significantly reduce the frequency of partial seizures. 10 , 3 , 1 , 4 , 6 Vigabatrin has been found to be well-tolerated and does not cause clinically significant adverse drug effects when added to established anticonvulsant therapy. 10

Risk Summary

Side effects such as drowsiness and visual disturbances (diplopia, ataxia, visual abnormalities) have been reported with vigabatrin. 10 These side effects appear to increase in a dose-dependent manner. 10 Some research also suggests that vigabatrin can have a negative impact on cognitive function in some patients. 6

Comparison Between Studies

Similarities Between Studies

Multiple studies have shown that vigabatrin is significantly more effective than placebo in reducing the frequency of partial seizures. 10 , 3 , 1 , 4 , 6 In these studies, vigabatrin was administered in addition to existing anticonvulsant medications. Vigabatrin has been found to be well-tolerated and does not cause clinically significant adverse drug effects. 10

Differences Between Studies

The dosage of vigabatrin varies between studies. 10 , 3 , 1 , 4 , 6 The frequency and severity of side effects also vary between studies. 10 , 3 , 1 , 4 , 6 Specifically, the possibility of vigabatrin having a negative impact on cognitive function is inconsistent across studies. 6

Consistency and Contradictions in the Results

Multiple studies have shown that vigabatrin is effective in treating partial seizures. 10 , 3 , 1 , 4 , 6 However, the possibility of vigabatrin having a negative impact on cognitive function is inconsistent across studies. 6 The dosage of vigabatrin and the frequency of side effects vary between studies, so further research is needed to resolve these inconsistencies. 10 , 3 , 1 , 4 , 6

Important Considerations for Real-Life Applications

Vigabatrin may be a valuable option for treating partial seizures. 10 However, some research suggests that vigabatrin can have a negative impact on cognitive function in some patients. 6 Side effects such as drowsiness and visual disturbances (diplopia, ataxia, visual abnormalities) have been reported with vigabatrin. 10 It is important to discuss these risks and benefits with your doctor before taking vigabatrin. 10 , 3 , 1 , 4 , 6

Limitations of Current Research

The research on vigabatrin is still incomplete. 10 , 3 , 1 , 4 , 6 Further research is needed to investigate the long-term effects and safety of vigabatrin, as well as its impact on cognitive function. 10 , 3 , 1 , 4 , 6

Future Directions for Research

Further research is needed to investigate the long-term effects and safety of vigabatrin, as well as its impact on cognitive function. 10 , 3 , 1 , 4 , 6 The dosage of vigabatrin and the frequency of side effects vary between patients, so developing personalized treatment approaches is also necessary. 10 , 3 , 1 , 4 , 6

Conclusion

Vigabatrin may be a valuable option for treating partial seizures. 10 However, some research suggests that vigabatrin can have a negative impact on cognitive function in some patients. 6 It is important to discuss these risks and benefits with your doctor before taking vigabatrin. 10 , 3 , 1 , 4 , 6 Further research is needed to investigate the long-term effects and safety of vigabatrin, as well as its impact on cognitive function. 10 , 3 , 1 , 4 , 6

Literature analysis of 12 papers
Positive Content
11
Neutral Content
1
Negative Content
0
Article Type
10
2
2
2
12
1.

Vigabatrin: rational treatment for chronic epilepsy.

Author: RingH A, HellerA J, FarrI N, ReynoldsE H

Reduced seizure frequency
Depression
Drowsiness
Headaches
Mood instability

Vigabatrin is a potentially valuable new treatment for chronic epilepsy, particularly partial seizures, but can cause side effects such as drowsiness, depression, and headaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effects of vigabatrin on evoked potentials in epileptic patients.

Author: CosiV, CalliecoR, GalimbertiC A, ManniR, TartaraA, MumfordJ, PeruccaE

Safe for long-term use
No significant risks

Vigabatrin, an anticonvulsant, did not affect somatosensory, brainstem auditory, or visual evoked potentials in patients with epilepsy, suggesting a favorable safety profile in terms of neurotoxicity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug-resistant epilepsy.

Author: LoiseauP, HardenbergJ P, PestreM, GuyotM, SchechterP J, TellG P

Epilepsy treatment
Confusion
Constipation
Drowsiness
Irritability
Nausea

Vigabatrin (GVG) (3 g/day) and placebo were compared in 19 patients with therapy-resistant epilepsy. GVG was associated with a significant reduction in seizure frequency, with 11 patients experiencing greater than 50% reduction. Adverse effects were generally mild, consisting of drowsiness, confusion, nausea, irritability, and constipation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Vigabatrin in the treatment of epilepsy: a double-blind, placebo-controlled study.

Author: TartaraA, ManniR, GalimbertiC A, HardenbergJ, OrwinJ, PeruccaE

Reduced seizure frequency
Ataxia
Drowsiness
Dysarthria
Headache
Vertigo

Vigabatrin was more effective than placebo in reducing seizures in patients with drug-resistant epilepsy. The most common side effect was drowsiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Long-term efficacy and cognitive effects of vigabatrin.

Author: YlinenA, KälviäinenR, RiekkinenP J

Effective add-on therapy
Well tolerated
Lack of efficacy

Vigabatrin is effective as add-on therapy in about 50% of patients with partial epilepsy refractory to drugs. As monotherapy, both vigabatrin and carbamazepine seem to be successful in a similar proportion of newly diagnosed patients with epilepsy, but carbamazepine monotherapy fails more often due to side-effects and vigabatrin more often due to lack of efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Effects of vigabatrin on partial seizures and cognitive function.

Author: GrünewaldR A, ThompsonP J, CorcoranR, CordenZ, JacksonG D, DuncanJ S

Improved cognitive function
Reduced seizure frequency
Aggression
Depression
Drowsiness
Headache
Lethargy

Vigabatrin significantly reduced complex partial seizure frequency in patients with refractory partial seizures, with 60% of responders maintaining the response after 44 weeks. However, it also caused a significant reduction in motor speed and a lower score on a design learning test, suggesting potential cognitive side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Evaluation of the effects of vigabatrin on cognitive abilities and quality of life in epilepsy.

Author: DodrillC B, ArnettJ L, SommervilleK W, SussmanN M

Epilepsy treatment
Vigabatrin effective
Little side effect

Vigabatrin, an antiepilepsy drug, had little impact on cognitive abilities or quality of life. In a study of 168 patients with focal epilepsy, there were no differences between vigabatrin and placebo groups on cognitive measures or mood assessments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Clinical and EEG/ERP brain mapping studies with vigabatrin in therapy refractory epileptic patients].

Author: PfersmannD, SaletuB, SemlitschH V, AndererP, DieterichH A

Good tolerability
Reduced CP frequency

Vigabatrin was effective in reducing complex partial seizures in therapy-resistant epilepsy and well-tolerated, with no significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

9.

The effects of vigabatrin on attention, concentration and mood: an investigation in healthy volunteers.

Author: ThomasL, TrimbleM

Cognition
Vigabatrin

Vigabatrin did not significantly affect cognition or mood in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A double-blind, placebo-controlled crossover study of vigabatrin 2 g/day and 3 g/day in uncontrolled partial seizures.

Author: BeranR G, BerkovicS F, BuchananN, DantaG, MackenzieR, SchapelG, SheeanG, VajdaF

Partial seizures treatment
Drowsiness
Visual disturbances

Vigabatrin, given in a daily dose of 2 g or 3 g, was significantly more effective than placebo in reducing seizure frequency among patients with partial seizures. Vigabatrin was well-tolerated but caused drowsiness and visual disturbances in a dose-related manner.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Vigabatrin for refractory partial epilepsy.

Author: HemmingKarla, MaguireMelissa J, HuttonJane L, MarsonAnthony G

Epilepsy treatment
Visual field constriction

Vigabatrin, an antiepileptic drug for refractory epilepsy, is generally well-tolerated. However, long-term use has been associated with asymptomatic visual field constriction, highlighting the need for monitoring during treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Vigabatrin for refractory partial epilepsy.

Author: HemmingKarla, MaguireMelissa J, HuttonJane L, MarsonAnthony G

Refractory epilepsy treatment
Visual field constriction

Vigabatrin is an antiepileptic drug that is used for the treatment of refractory epilepsy. Although vigabatrin is generally well tolerated, it can cause asymptomatic visual field constriction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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