Side Effects of yellow fever vaccine: A Synthesis of Findings from 30 Studies

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Original Abstract of the Article

Major Research Findings

Yellow fever vaccine is generally considered safe and effective. However, in recent years, rare cases of serious side effects have been reported. 11 reports a case of a 23-year-old woman who developed severe viscerotropic disease and encephalitis after receiving the yellow fever vaccine. This patient had decreased expression of Fc-gamma receptors (CD16, CD32, and CD64) in monocytes, along with increased levels of NK T cells, activated T cells (CD4(+) and CD8(+) cells), and B lymphocytes. 25 is a retrospective study on the safety of yellow fever vaccine in patients with diabetes mellitus, and no side effects were reported in diabetic patients. 8 is a randomized, double-blind, controlled trial that evaluated whether coadministration of the yellow fever (YF) virus vaccine with human immunoglobulin (Ig) that contained YF virus-neutralizing antibodies would reduce post-vaccination viremia without compromising immunogenicity and thus, potentially mitigate YF vaccine-associated adverse events. In this study, no difference was found in the proportion of vaccinated participants who developed viremia, seroconversion, cluster of differentiation (CD)-8(+) and CD4(+) T-cell responses, and cytokine responses between the two groups. 13 reports on adverse events following yellow fever preventive vaccination campaigns in eight African countries from 2007 to 2010. The paper reports that serious, but rare adverse events following immunization (AEFI) have been reported with yellow fever (YF) 17D vaccine, including severe allergic reactions, YF vaccine-associated neurologic disease (YEL-AND), and YF vaccine-associated viscerotropic disease (YEL-AVD). The frequency with which YEL-AND and YEL-AVD occur in YF endemic countries is mostly unknown. Serious side effects are rare, but the risk may be higher, especially in the elderly and immunocompromised individuals. 3 reports on adverse events following yellow fever immunization in Brazil. This paper analyzed 67 neurological cases found from 2007 to 2012. The highest rate of neurological adverse events was found in the age group from 5 to 9 years. However, these adverse events generally have a good prognosis and should not contraindicate the use of yellow fever vaccine in the face of the risk of infection by yellow fever virus. 4 investigated risk groups for yellow fever vaccine-associated viscerotropic disease (YEL-AVD). This paper identified elderly males, women between the ages of 19 and 34, people with a variety of autoimmune diseases, individuals who have been thymectomized because of thymoma, and infants and children ≤11 years old as risk groups for YEL-AVD. YEL-AVD does not negate the fact that yellow fever vaccine is safe and effective, but it is important to understand the risks and take appropriate precautions.

Reasons for Side Effects

Side effects of the yellow fever vaccine may be caused by allergic reactions to vaccine components, infection by the vaccine virus, or abnormal immune reactions. 18 is a study that investigated serious adverse events associated with the yellow fever vaccine. This paper suggests that the cause of serious adverse events is largely unknown and may be related to individual host factors. Additionally, side effects of the yellow fever vaccine may vary depending on factors such as age and immune status. 2 is a study that investigated the risk of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) in the elderly. This study suggested that the elderly may be at increased risk of YEL-AVD. However, this paper concluded that further research is needed on the risk of YEL-AVD in the elderly.

Common Side Effects

Pain at the injection site

Pain and swelling at the injection site may occur after receiving the yellow fever vaccine. 19 is a study that investigated the occurrence of side effects in people who received the yellow fever vaccine in Brazil. This study found no significant difference in side effects between those who received the normal dose and those who received a 25-fold concentrated dose of the vaccine.

Fever

Fever may occur after receiving the yellow fever vaccine. 1 is a study that investigated the safety and efficacy of yellow fever vaccine in infants aged 7 to 8 months. This study reported fever as the most significant immediate and delayed side effect. 12 children (15.6%) experienced fever within 48 hours of vaccination, while 10 children (12.9%) experienced fever within 10 days of vaccination. Other side effects such as pain at the injection site and vomiting were also reported.

Fatigue

Fatigue and headache may occur after receiving the yellow fever vaccine. 27 is a double-blind randomized clinical trial that evaluated the immunogenicity and safety of the 17DD yellow fever vaccine (17DD-YFV) in Brazil. This study investigated the dose-response relationship of the vaccine and found that low-dose 17DD-YFV was as immunogenic and safe as the current formulation. However, this study did not mention fatigue as a side effect.

Allergic reactions

Allergic reactions may occur after receiving the yellow fever vaccine. 11 reports a case of a 23-year-old woman who developed severe viscerotropic disease and encephalitis after receiving the yellow fever vaccine. This patient had potential allergic reactions. However, this study did not mention specific symptoms of allergic reactions.

Neurological side effects

Rarely, neurological side effects such as encephalitis and paralysis may occur after receiving the yellow fever vaccine. 28 reports on two fatal cases of hemorrhagic fever associated with yellow fever 17DD substrain vaccine in Brazil. This study suggests that the yellow fever vaccine may cause serious neurological side effects. Yellow fever vaccine-associated neurologic disease (YEL-AND) is more likely to occur in children and older adults. 16 is a paper that explains immunization against yellow fever. This paper points out that neurological side effects from the yellow fever vaccine are rare, but tend to be more frequent in older adults. However, this paper does not mention specific symptoms of side effects. Neurological side effects may occur weeks to months after vaccination. 3 reports on adverse events following yellow fever immunization in Brazil. This paper analyzed 67 neurological cases found from 2007 to 2012. The highest rate of neurological adverse events was found in the age group from 5 to 9 years. However, these adverse events generally have a good prognosis and should not contraindicate the use of yellow fever vaccine in the face of the risk of infection by yellow fever virus.

Viscerotropic Disease

Rarely, viscerotropic disease, which affects the internal organs such as the liver and kidneys, may occur after receiving the yellow fever vaccine. Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is serious and can often be fatal. 4 investigated risk groups for yellow fever vaccine-associated viscerotropic disease (YEL-AVD). This paper identified elderly males, women between the ages of 19 and 34, people with a variety of autoimmune diseases, individuals who have been thymectomized because of thymoma, and infants and children ≤11 years old as risk groups for YEL-AVD.

Other

Other symptoms such as nausea, vomiting, abdominal pain, muscle aches, joint pain, and swollen lymph nodes may occur after receiving the yellow fever vaccine. 29 reports a case of a rare local vesicular reaction to the yellow fever vaccine. This paper reports that the patient developed vesicular lesions resulting in bullae and circumferential hyperpigmentation.

Countermeasures for Side Effects

Pain at the injection site

Cold compresses and analgesics can be used for pain at the injection site. Massaging the injection site may also be effective.

Fever

Antipyretics can be taken for fever. It is also important to stay hydrated. If fever persists, see a doctor.

Fatigue

It is important to get enough rest for fatigue. Light exercise may also be effective. If fatigue persists, see a doctor.

Allergic reactions

If you have an allergic reaction, seek medical attention immediately. Serious allergic reactions can be life-threatening.

Neurological side effects

If you suspect neurological side effects, seek medical attention immediately. Serious neurological side effects can lead to permanent disabilities.

Viscerotropic disease

If you suspect viscerotropic disease, seek medical attention immediately. Viscerotropic disease can be life-threatening if left untreated.

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that the yellow fever vaccine is generally safe and effective. However, serious side effects can occur, albeit rarely. The risk of serious side effects may be higher, especially in the elderly and immunocompromised individuals.

Differences in Studies

Multiple studies have shown that side effects of the yellow fever vaccine may vary depending on factors such as age and immune status. For example, 2 suggests that the elderly may be at increased risk of yellow fever vaccine-associated viscerotropic disease (YEL-AVD). On the other hand, 25 reported no side effects of yellow fever vaccine in patients with diabetes mellitus.

Precautions for Real-Life Application

The yellow fever vaccine is recommended for travelers to areas where yellow fever is prevalent and for those who work in these areas. When considering yellow fever vaccination, it is important to consult with a doctor to assess your health status and risks. If you experience side effects after receiving the yellow fever vaccine, see a doctor immediately.

Limitations of Current Research

Research on side effects of the yellow fever vaccine is still insufficient. Further research is needed, especially on the incidence and mechanisms of side effects in the elderly and immunocompromised patients. In addition, future research is needed on countermeasures to reduce side effects of the yellow fever vaccine.

Future Research Directions

Research on side effects of the yellow fever vaccine needs to focus on the following points:

  • Incidence and mechanisms of side effects in the elderly and immunocompromised patients
  • Countermeasures to reduce side effects of the yellow fever vaccine
  • Development of safer and more effective yellow fever vaccines

Conclusion

The yellow fever vaccine is generally considered safe and effective. However, serious side effects can occur, albeit rarely. The risk of serious side effects may be higher, especially in the elderly and immunocompromised individuals. When considering yellow fever vaccination, it is important to consult with a doctor to assess your health status and risks. If you experience side effects after receiving the yellow fever vaccine, see a doctor immediately.

Literature analysis of 30 papers
Positive Content
25
Neutral Content
1
Negative Content
4
Article Type
3
0
1
8
28
1.

Safety and efficacy of yellow fever vaccine in children less thanone-year-old.

Author: OsinusiK, AkinkugbeF M, AkinwolereO A, FabiyiA

Safe and effective yellow fever vaccine
Fever
Pain
Vomiting

Yellow fever vaccine was found to be safe and fairly effective in infants. In a clinical trial of 77 children aged seven to eight months, the most significant side effect was fever, occurring in 15.6% of children within 48 hours of vaccination and 12.9% within 10 days. Seroconversion rates were lower than those reported in adults and older children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Risk of yellow fever vaccine-associated viscerotropic disease among the elderly: a systematic review.

Author: RaffertyEllen, DuclosPhilippe, YactayoSergio, SchusterMelanie

YEL-AVD risk

Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a rare but serious adverse event of yellow fever (YF) vaccine. This review found that two out of five studies found a significantly higher rate of YEL-AVD among the elderly population. While the evidence remains limited, these findings suggest that unexposed elders may be at an increased risk of developing YEF-AVD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Adverse events following yellow fever immunization: Report and analysis of 67 neurological cases in Brazil.

Author: MartinsReinaldo de Menezes, PavãoAna Luiza Braz, de OliveiraPatrícia Mouta Nunes, dos SantosPaulo Roberto Gomes, CarvalhoSandra Maria D, MohrdieckRenate, FernandesAlexandre Ribeiro, SatoHelena Keico, de FigueiredoPatricia Mandali, von DoellingerVanessa Dos Reis, LealMaria da Luz Fernandes, HommaAkira, MaiaMaria de Lourdes S

Good neurological prognosis
Yellow fever vaccine safety
Neurological adverse events

This study analyzed neurological adverse events following administration of the 17DD substrain of yellow fever vaccine (YEL-AND) in Brazil. The highest rate of neurological adverse events was observed in the age group from 5 to 9 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Risk groups for yellow fever vaccine-associated viscerotropic disease (YEL-AVD).

Author: SeligmanStephen J

Death
YEL-AVD

This review identifies risk groups for yellow fever vaccine-associated viscerotropic disease (YEL-AVD), a severe, often fatal complication of the yellow fever vaccine. Risk groups include elderly males, women between 19 and 34, individuals with autoimmune diseases, and thymectomized individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy.

Author: Sicre de FontbruneFlore, ArnaudCécile, CheminantMorgane, BoulayAude, KonopackiJohana, LapusanSimona, RobinChristine, BernaudinFrançoise, SuarezFelipe, SimonFrançois, SociéGérard, Colin de VerdièreNathalie, ConsignyPaul-Henri

No side effects
Protective immunity

Yellow fever vaccine is not routinely given to allogeneic hematopoietic stem cell transplant recipients due to concerns about its safety. This study found that YFV was safe and effective in a group of HSCT recipients, suggesting that it could be considered for routine use in this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Safety of 17D derived yellow fever vaccines.

Author: DomingoCristina, NiedrigMatthias

Effective vaccine
Severe side effects

Yellow fever vaccine (YFSAE) can cause serious adverse events, including hypersensitivity reactions, neurotropic and viscerotropic syndromes. The incidence of YFSAE is associated with increasing age and thymus disorders. Further research is needed to better understand the causes of these adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Viscerotropic disease and acute uveitis following yellow fever vaccination: a case report.

Author: VolkovLev, GrardGilda, BollaertPierre-Edouard, DurandGuillaume A, CravoisyAurélie, ConradMarie, NaceLionel, CourteGuilhem, MarnaiRémy, Leparc-GoffartIsabelle, GibotSébastien

Yellow fever vaccine complications

This study reports a case of a patient who presented both viscerotropic and neurological manifestations after yellow fever vaccination, highlighting the potential for rare but serious complications.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A randomized, double-blind, controlled trial of the 17D yellow fever virus vaccine given in combination with immune globulin or placebo: comparative viremia and immunogenicity.

Author: EdupugantiSrilatha, EidexRachel B, KeyserlingHarry, AkondyRama S, LanciottiRobert, OrensteinWalter, del RioCarlos, PanYi, QuerecTroy, LipmanHarvey, BarrettAlan, AhmedRafi, TeuwenDirk, CetronMartin, MulliganMark J,

Immunogenicity
YF vaccine efficacy

This study evaluated the effect of co-administering yellow fever vaccine with human immunoglobulin containing neutralizing antibodies. It found no difference in viremia, immunogenicity, or adverse events between the two groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Deaths following vaccination: What does the evidence show?

Author: MillerElaine R, MoroPedro L, CanoMaria, ShimabukuroTom T

Vaccine safety
Anaphylaxis
Eczema vaccinatum
Guillain-Barré syndrome
Intussusception
Progressive vaccinia

This study discussed the safety of vaccines in the United States, particularly in light of unsubstantiated claims of deaths caused by vaccines. The study reviewed epidemiologic data on deaths following vaccination, noting that while serious adverse reactions are rare, coincidental events do occur. The study emphasized the importance of relying on scientific evidence rather than anecdotal reports to assess vaccine safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Yellow Fever outbreaks in unvaccinated populations, Brazil, 2008-2009.

Author: RomanoAlessandro Pecego Martins, CostaZouraide Guerra Antunes, RamosDaniel Garkauskas, AndradeMaria Auxiliadora, JaymeValéria de Sá, AlmeidaMarco Antônio Barreto de, VettorelloKátia Campomar, MascherettiMelissa, FlanneryBrendan

Yellow fever prevention
Vaccine-associated adverse events

Yellow fever outbreaks in Brazil resulted in 21 confirmed cases with 9 deaths in Rio Grande do Sul and 28 cases with 11 deaths in Sao Paulo. Over 5.5 million doses of vaccine were administered, resulting in six deaths (0.8 per million doses) and 45 cases (5.6 per million doses) of vaccine-associated adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination.

Author: SilvaMaria Luiza, Espírito-SantoLuçandra Ramos, MartinsMarina Angela, Silveira-LemosDenise, Peruhype-MagalhãesVanessa, CaminhaRicardo Carvalho, de Andrade Maranhão-FilhoPéricles, Auxiliadora-MartinsMaria, de Menezes MartinsReinaldo, GallerRicardo, da Silva FreireMarcos, MarcovistzRugimar, HommaAkira, TeuwenDirk E, Elói-SantosSilvana Maria, AndradeMariléia Chaves, Teixeira-CarvalhoAndréa, Martins-FilhoOlindo Assis

YF vaccine tolerance
YEL-SAE occurrence

A 23-year-old female patient developed a suspected case of severe YEL-AVD with encephalitis, as well as with pancreatitis and myositis, following receipt of a 17D-204 YF vaccination. The patient exhibited a decreased level of expression of Fc-gammaR in monocytes (CD16, CD32, and CD64), along with increased levels of NK T cells (an increased CD3(+) CD16(+/-) CD56(+/-)/CD3(+) ratio), activated T cells (CD4(+) and CD8(+) cells), and B lymphocytes.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Novel approaches in the treatment of Hansen's disease (Leprosy): a case series of multidrug therapy of monthly rifampin, moxifloxacin, and minocycline (RMM) in the United States.

Author: Franco-ParedesCarlos, Garcia-CreightonElizabeth, Henao-MartínezAndrés, KallgrenDiane L, BanjadeRashmi, DyerJon A, NelsonTaylor, ZaesimAraya, PelusoMichael J, JainVivek, LeeDong Heun, MincesLucio R, WirshupMary, Sierra HoffmanMiguel, KatsolisJenn, BrustKaren, GironJose, SmiarowskiLauren, Hoosepian-MerPauline A, StryjewskaBarbara

Improved safety
Leprosy treatment

This case series reports the successful treatment of 10 patients with Hansen's disease (HD) using a monthly regimen of rifampin, moxifloxacin, and minocycline (RMM). All patients completed the regimen without interruptions and experienced rapid improvement of skin lesions with no significant side effects. The results suggest RMM as a potential first-line therapy for HD.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

14.

Active assessment of adverse events following yellow fever vaccination of persons aged 60 years and more.

Author: MiyajiKarina Takesaki, LuizAndré Machado, LaraAmanda Nazareth, do Socorro Souza ChavesTania, PiorelliRoberta de Oliveira, LopesMarta Heloisa, SartoriAna Marli Christovam

Safe yellow fever vaccination
Adverse events

Most persons aged ≥ 60 y may be safely vaccinated against YF. Before vaccination, they must be carefully screened for conditions associated to altered immunocompetence and for risk of exposure to YF.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

15.

Yellow fever vaccination in organ transplanted patients: is it safe? A multicenter study.

Author: AzevedoL S, LasmarE P, ContieriF L C, BoinI, PercegonaL, SaberL T S, SelistreL S, NettoM V P, MoreiraM C V, CarvalhoR M, BrunoR M, FerreiraT C A, David-NetoE

YF vaccine effectiveness
Contraindicated in immunocompromised patients
Life-threatening side effects

This study examined the risk of yellow fever vaccine (YFV) in transplant patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

16.

[Immunization against yellow fever].

Author: LandryP, GentonB

Yellow fever protection
Neurological side effects
Vaccine side effects

Yellow fever vaccine is highly effective in preventing the disease, which is severe but rare in travelers. However, rare but serious systemic side effects have been reported, particularly in older adults. Strict adherence to vaccine indications and contraindications is crucial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

17.

Safety and immunogenicity of a primary yellow fever vaccination under low-dose methotrexate therapy-a prospective multi-centre pilot study1.

Author: BühlerSilja, JaegerVeronika Katharina, EperonGilles, FurrerHansjakob, FuxChristoph A, JansenStephanie, NeumayrAndreas, RochatLaurence, SchmidSabine, Schmidt-ChanasitJonas, StaehelinCornelia, de VisserAdriëtte W, VisserLeonardus G, NiedrigMatthias, HatzChristoph

Yellow fever vaccination

This study compared the safety and immunogenicity of yellow fever vaccination (YFVV) in travelers on methotrexate, an immunosuppressant medication, and controls. Methotrexate can suppress the immune system, potentially affecting vaccine efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

19.

Low frequency of side effects following an incidental 25 times concentrated dose of yellow fever vaccine.

Author: RabelloAna, OrsiniMarcela, DischJolande, MarcialTânia, Leal MdMaria da Luz F, Freire MdMarcos da Silva, YamamuraAnna M Yoshida, VianaAngelo

Yellow fever vaccine safety

This study investigates the safety of a 25 times concentrated dose of the 17-DD yellow fever vaccine given to 14 adults. The results show that the concentrated vaccine was well-tolerated, with no significant adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

A public health risk assessment for yellow fever vaccination: a model exemplified by an outbreak in the state of São Paulo, Brazil.

Author: RibeiroAna Freitas, TenganCiléa, SatoHelena Keico, SpinolaRoberta, MascherettiMelissa, FrançaAna Cecilia Costa, Port-CarvalhoMarcio, PereiraMariza, SouzaRenato Pereira de, AmakuMarcos, BurattiniMarcelo Nascimento, CoutinhoFrancisco Antonio Bezerra, LopezLuis Fernandez, MassadEduardo

Minimized deaths
YF vaccine-induced fatalities

A mathematical model was used to calculate the optimal vaccination proportion for yellow fever (YF) outbreaks in São Paulo, Brazil. This was done to minimize the total number of deaths, considering the risk of vaccine-induced fatalities and the risk of YF outbreaks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Yellow fever vaccine and risk of developing serious adverse events: a systematic review.

Author: PorudominskyRuben, GotuzzoEduardo H

YFV safety
AEs in risk groups

YFV safety has been confirmed based on data from many vaccination campaigns and multiple studies. AEs seem more frequent after a first-time dose, mainly in risk groups, but the vaccine was found to be safe in most of them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Cutaneous lesions caused by the yellow fever vaccine - have you ever seen them?

Author: LiseMichelle Larissa Zini, LiseMichael Laurence Zini

Skin rash

This case report describes a rash on a toddler who received the yellow fever vaccine. Although skin rash is a known side effect of the vaccine, no detailed description or images of the lesions have been reported in the literature.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Tolerance and humoral immune response to the yellow fever vaccine in sickle cell disease children treated with hydroxyurea: a multicentre prospective study.

Author: KoehlBerengere, AupiaisCamille, SchinckelNelly, MornandPierre, OdièvreMarie-Hélène, NiakateAssa, BrousseValentine, IthierGhislaine, MissudFlorence, HolvoetLaurent, BenkerrouMalika, SorgeFrederic, FayeAlbert

YF vaccination in SCD

This study compared the tolerance and immune response to yellow fever (YF) vaccination in sickle cell disease (SCD) children treated or not with hydroxyurea (HU).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

25.

Vaccination of patients with diabetes mellitus--a retrospective study.

Author: Mad'arRastislav, BenesováDagmar, BrandejskáDana, CermákováMiriam, DvorkováAlena, GazárkováOlga, JakubalováSilvana, KochováIlona, LastovickováJana, NebázniváDagmar, OrolinováMarta, PolomisKarel, RehkaVáclav, SattranováLudmila, SchejbalováMiriam, SlámováAlena, SkalleováDeanna, SevcíkováHana, TkadlecováHana, TmejováMarta, TrmalJosef, TurkováDagmar

Vaccination safety

This retrospective study examined the safety of vaccination in diabetic patients. 402 diabetic patients were vaccinated during a 9.5-month period, with no unexpected side effects observed. Vaccination is generally safe for diabetic patients, but live attenuated vaccines should be considered cautiously.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Awareness of Inadvertent Use of Yellow Fever Vaccine Among Recipients of Renal Transplant.

Author: MirandaLara Judith Cabral, AgenaFabiana, SartoriAna Marli Christovam, David-NetoElias, AzevedoLuiz Sergio, PierrottiLígia Camera

Inadvertent vaccination
Life-threatening side effects

Renal transplant recipients are at risk of serious side effects from yellow fever vaccine (YFV) due to their immunosuppressed state. This study found that 11 out of 116 patients (9.5%) received YFV despite the contraindication, and most of them were unaware of the risk. This highlights the importance of counseling renal transplant recipients about the contraindications of YFV.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

17DD yellow fever vaccine: a double blind, randomized clinical trial of immunogenicity and safety on a dose-response study.

Author: MartinsReinaldo M, MaiaMaria de Lourdes S, FariasRoberto Henrique G, CamachoLuiz Antonio B, FreireMarcos S, GallerRicardo, YamamuraAnna Maya Yoshida, AlmeidaLuiz Fernando C, LimaSheila Maria B, NogueiraRita Maria R, SáGloria Regina S, HokamaDarcy A, de CarvalhoRicardo, FreireRicardo Aguiar V, Pereira FilhoEdson, LealMaria da Luz Fernandes, HommaAkira

Immunogenic at lower doses
Safe at lower doses

Bio-Manguinhos/Fiocruz yellow fever vaccine can be used in much lower doses than usual.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases.

Author: VasconcelosP F, LunaE J, GallerR, SilvaL J, CoimbraT L, BarrosV L, MonathT P, RodiguesS G, LavalC, CostaZ G, VilelaM F, SantosC L, PapaiordanouP M, AlvesV A, AndradeL D, SatoH K, RosaE S, FroguasG B, LacavaE, AlmeidaL M, CruzA C, RoccoI M, SantosR T, OlivaO F, PapaiordanouC M,

Hemorrhagic fever

Two fatal cases of hemorrhagic fever associated with yellow fever 17DD substrain vaccine were reported in Brazil. Yellow fever virus was recovered from blood and viscera of both patients, suggesting a rare and serious complication of the vaccine.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

An Atypical Local Vesicular Reaction to the Yellow Fever Vaccine.

Author: WautersRobert H, HernandezCamellia L, PetersenMaureen M

Yellow fever protection
Vesicular lesions

This case report describes a rare adverse reaction to yellow fever vaccine in which a patient developed vesicular lesions, bullae, and hyperpigmentation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

30.

Safety profile of the yellow fever vaccine Stamaril®: a 17-year review.

Author: CottinPascale, NiedrigMatthias, DomingoCristina

YF vaccine
Anaphylaxis

This review of an electronic pharmacovigilance database for Stamaril® yellow fever vaccine found that the vaccine's safety profile in routine practice is favorable and consistent with the summary of product characteristics. Reporting rates of serious adverse events associated with Stamaril vaccination are lower than previously published estimates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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