Side Effects of zanamivir oral inhalation: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Major Research Findings

Zanamivir inhalation has been shown to be effective in preventing influenza. 2 showed that zanamivir inhalation is effective in preventing influenza. 4 showed that zanamivir inhalation is effective in treating influenza and is an attractive option for children due to its delivery method. 3 showed that zanamivir inhalation is effective in treating and preventing influenza.

Reasons for Side Effects

The reason for side effects of zanamivir inhalation is that the drug is absorbed into the body and its components affect various tissues and organs. Side effects vary depending on the amount of medication and the individual's constitution.

Common Side Effects

Fever

Zanamivir inhalation may cause fever. 1 reported fever in 15.6% of children who received yellow fever vaccine. Fever is believed to be caused by the drug acting on the body. 1

Pain at the injection site

Pain may occur at the injection site of zanamivir inhalation. 1 reported pain at the injection site in 5.2% of children who received yellow fever vaccine. Pain at the injection site is thought to be caused by the drug's components acting on the skin. 1

Vomiting

Zanamivir inhalation may cause vomiting. 1 reported vomiting in 1.3% of children who received yellow fever vaccine. Vomiting is believed to be caused by the drug acting on the digestive system. 1

Side Effect Countermeasures

Fever

If you develop fever, consult a doctor and take appropriate medication. 1 reported fever as a side effect of yellow fever vaccine, but most cases improved with antipyretics. 1

Pain at the injection site

If you experience severe pain at the injection site, consult a doctor. 1 reported pain at the injection site as a side effect of yellow fever vaccine, but no specific countermeasures were mentioned. 1

Vomiting

If you continue to vomit, consult a doctor. 1 reported vomiting as a side effect of yellow fever vaccine, but no specific countermeasures were mentioned. 1

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that zanamivir inhalation is effective in preventing and treating influenza. 2 , 4 , 3 . Studies have also shown that zanamivir inhalation is relatively safe. 2 , 4 , 3 . However, 1 reported fever in 15.6% of children who received yellow fever vaccine. While this is not directly related to side effects of zanamivir inhalation, it is important information regarding the safety of medications. 1

Differences of Studies

Reports of side effects of zanamivir inhalation vary depending on the study. For example, 1 reported fever in 15.6% of children who received yellow fever vaccine, but no other studies reported fever as a side effect of zanamivir inhalation. 1

Considerations for Real-World Applications

Zanamivir inhalation is an effective drug for preventing and treating influenza, but there is a risk of side effects. Therefore, it is important to consult a doctor and understand the risks of side effects before using zanamivir inhalation. If you experience any adverse reactions while using zanamivir inhalation, consult a doctor immediately. 2 , 4 , 3 , 1

Limitations of Current Research

There is not enough research on the side effects of zanamivir inhalation. Therefore, there are still many unknowns about the long-term safety of zanamivir inhalation and the risk of side effects in certain populations. 2 , 4 , 3 , 1

Future Research Directions

Further research is needed on the long-term safety of zanamivir inhalation and the risk of side effects in certain populations. Research is also needed on ways to reduce side effects of zanamivir inhalation. 2 , 4 , 3 , 1

Conclusion

Zanamivir inhalation is an effective drug for preventing and treating influenza, but there is a risk of side effects. It is important to consult a doctor and understand the risks of side effects before using zanamivir inhalation. 2 , 4 , 3 , 1

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
0
Article Type
2
0
0
1
4
1.

Safety and efficacy of yellow fever vaccine in children less thanone-year-old.

Author: OsinusiK, AkinkugbeF M, AkinwolereO A, FabiyiA

Safe and effective yellow fever vaccine
Fever
Pain
Vomiting

Yellow fever vaccine was found to be safe and fairly effective in infants. In a clinical trial of 77 children aged seven to eight months, the most significant side effect was fever, occurring in 15.6% of children within 48 hours of vaccination and 12.9% within 10 days. Seroconversion rates were lower than those reported in adults and older children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Oseltamivir and inhaled zanamivir as influenza prophylaxis in Thai health workers: a randomized, double-blind, placebo-controlled safety trial over 16 weeks.

Author: AnekthananonT, PukrittayakameeS, PukritayakameeS, RatanasuwanW, JittamalaP, WerarakP, CharunwatthanaP, SuwanagoolS, LawpoolsriS, StepniewskaK, SapchookulP, PuthavathanaP, FukudaC, LindegardhN, TarningJ, WhiteN J, DayN, TaylorW R J

Influenza prophylaxis
Intercurrent infections

Oseltamivir and zanamivir were well tolerated in healthy hospital professionals for primary influenza prophylaxis over 16 weeks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Antivirals for influenza: strategies for use in pediatrics.

Author: SmithSteven M, GumsJohn G

Influenza treatment
Reduced bacterial infections
Drug resistance
Neuropsychiatric events

Influenza infection is a major cause of morbidity and mortality, especially in children. While vaccination is recommended, its efficacy is reduced in children. Antiviral therapies, particularly neuraminidase inhibitors, are effective treatment options. However, emerging resistance and potential neuropsychiatric side effects are concerns.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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