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Lipid abnormalities associated with protease inhibitors.

Author: HenryK, HuebschJ, KopaczewskiJ, MelroeN H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Protease inhibitors are effective for HIV treatment but may cause significant lipid abnormalities. This study found that 56% of patients on three different protease inhibitor therapies had elevated lipids. The increase in cholesterol was 80% for norvir/saquinavir, 51% for indinavir, and 47% for nelfinavir.
Paper Details　
Original Abstract of the Article :
Treatment for HIV infection in the past 3 years has significantly improved the prognosis of people infected with HIV. Protease inhibitors have played a critical role in this improved prognosis. Recent findings indicate, however, that protease inhibitors may cause significant alterations in lipid met...See full text at original site
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引用元：
https://doi.org/10.1016/S1055-3290(06)60296-3

データ提供：米国国立医学図書館（NLM）

The Hidden Dunes of Protease Inhibitors: Unexpected Side Effects

The field of [HIV treatment] has witnessed remarkable advancements, with protease inhibitors playing a pivotal role in improving patient outcomes. However, this research highlights a potentially serious side effect associated with these medications: [lipid abnormalities]. Through [a comprehensive review], the researchers identified that a significant proportion of patients treated with protease inhibitors experienced [elevated lipid levels]. This discovery underscores the importance of [ongoing monitoring and management] of lipid profiles in HIV-infected individuals receiving protease inhibitor therapy.

A Shifting Landscape in HIV Treatment

The findings suggest that protease inhibitors, while effective in combating HIV, may carry an [unexpected risk] for patients. The study revealed that [56%] of patients treated with protease inhibitors developed abnormal lipid levels, emphasizing the need for [close medical supervision] and timely intervention to mitigate potential complications.

Navigating the Oasis of HIV Treatment

The study's findings serve as a reminder that even with significant advancements in medical treatment, potential side effects must be carefully considered. This knowledge empowers both healthcare professionals and patients to make informed decisions regarding treatment options and monitor their health closely.

Dr. Camel's Conclusion

Protease inhibitors have revolutionized HIV treatment but can come with the unexpected side effect of lipid abnormalities. This research underscores the importance of comprehensive patient care and close monitoring of lipid levels in HIV-infected individuals receiving protease inhibitor therapy.

Date :
  1. Date Completed 1999-04-23
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

10065407

DOI: Digital Object Identifier

10.1016/S1055-3290(06)60296-3

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Article Analysis
・Side Effects of saquinavir
SNS
PICO Info
in preparation
Languages

English

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