A safety and pharmacokinetic study of intravenous natalizumab in patients with MS.

Author: KollerM, SheremataW A, StoneL A, VollmerT L, Willmer-HulmeA J

Paper Details 
Original Abstract of the Article :
A phase 1, randomized, placebo-controlled, five-level dose escalation safety and tolerability and pharmacokinetic study of a single IV dose of natalizumab was performed. Doses of 0.03 to 3.0 mg/kg natalizumab or placebo were studied in 28 stable relapsing-remitting or secondary-progressive MS. All d...See full text at original site
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引用元:
https://doi.org/10.1212/wnl.52.5.1072

データ提供:米国国立医学図書館(NLM)

Natalizumab: A New Oasis in the Desert of Multiple Sclerosis Treatment

The world of multiple sclerosis (MS) treatment is a vast and challenging desert, with ongoing efforts to find new and effective therapies. This study, published in the journal '[Journal Name]', investigates the safety and pharmacokinetics of natalizumab, a monoclonal antibody that targets the alpha-4 integrin, in patients with MS. The researchers conducted a phase 1, randomized, placebo-controlled, dose-escalation study to assess the safety and tolerability of intravenous natalizumab in patients with MS.

The study found that natalizumab was safe and well-tolerated in patients with MS, even at high doses. The researchers also observed that serum concentrations of natalizumab were detectable for several weeks after a single intravenous dose, justifying further investigation of its potential efficacy in treating MS.

Navigating the Desert of Multiple Sclerosis

This study offers a promising new oasis in the desert of MS treatment. The findings demonstrate the safety and tolerability of natalizumab, paving the way for further investigation into its potential efficacy as a treatment for MS. This discovery is a testament to the power of continued research and innovation in developing new and effective therapies for complex neurological conditions.

Seeking a Cool Oasis in the Desert of Neurological Disease

The desert of neurological disease can be a harsh and unforgiving landscape for patients. This study suggests that natalizumab, like a refreshing oasis, may offer a potential path to managing the debilitating symptoms of MS. The findings underscore the importance of continued research in developing new and effective treatments to navigate the challenging landscape of neurological disease.

Dr.Camel's Conclusion

This study investigates the safety and pharmacokinetics of natalizumab, a monoclonal antibody that targets the alpha-4 integrin, in patients with MS. The research demonstrates the safety and tolerability of natalizumab, paving the way for further investigation into its potential efficacy as a treatment for MS. The study serves as a reminder that continued exploration and innovation are crucial in finding new and effective solutions for a variety of medical conditions, especially those with complex neurological underpinnings.

Date :
  1. Date Completed 1999-05-06
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

10102433

DOI: Digital Object Identifier

10.1212/wnl.52.5.1072

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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