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Prevention of nonsteroidal anti-inflammatory drug-induced gastropathy: clinical and economic implications of a single-tablet formulation of diclofenac/misoprostol.

Author: GoldsteinJ L, LarsonL R, YamashitaB D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

NSAID use is associated with gastroduodenal injury and a 2%-4% annual risk for symptomatic gastroduodenal ulceration, hemorrhage, and perforation. Diclofenac/misoprostol is effective in treating signs and symptoms of arthritis and in reducing the incidence of NSAID-induced gastroenteropathy.
Paper Details　
Original Abstract of the Article :
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage arthritis. While controlling symptoms and improving quality of life, NSAID use is associated with gastroduodenal injury and a 2%-4% annual risk for symptomatic gastroduodenal ulceration, hemorrhage, and perforation. This requi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10179922

データ提供：米国国立医学図書館（NLM）

Preventing Nonsteroidal Anti-inflammatory Drug-Induced Gastropathy

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to manage arthritis, providing relief from pain and improving quality of life. However, NSAID use is associated with a significant risk of gastroduodenal injury, including ulceration, hemorrhage, and perforation. The research delves into the clinical and economic implications of NSAID-induced gastropathy. It examines the challenges faced by clinicians in balancing the benefits of NSAIDs with the potential risks, exploring strategies for risk assessment and management. The authors delve into the economic burden associated with NSAID-induced gastroenteropathy and present a compelling case for the use of preventive therapies, particularly for high-risk patients.

Balancing Pain Relief with Gastrointestinal Risks

This study serves as a reminder that while NSAIDs are valuable tools in pain management, their use must be carefully considered. The risk of gastrointestinal complications is significant, particularly for patients with pre-existing conditions or risk factors. The authors present a comprehensive overview of the economic and clinical implications of NSAID-induced gastropathy, urging clinicians to prioritize the prevention of these complications, particularly for those at higher risk.

The Importance of Preventive Therapies in Managing Arthritis

This research highlights the importance of preventive therapies in managing arthritis. The study emphasizes the need to identify and stratify patients based on their risk for developing NSAID-induced gastropathy. Early intervention and preventative measures can significantly reduce the incidence of serious complications and improve patient outcomes.

Dr. Camel's Conclusion

Just as a wise traveler in a desert knows the importance of carrying water, clinicians must be vigilant in mitigating the gastrointestinal risks associated with NSAID use. This research emphasizes the importance of preventive therapies and risk assessment in managing arthritis, guiding clinicians towards a more informed and safer approach to pain management.
Date :
  1. Date Completed 1998-07-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10179922

DOI: Digital Object Identifier

1733

Related Literature

Article Analysis
・Effects of diclofenac and misoprostol
SNS
PICO Info
in preparation
Languages

English

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