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Effects of the inhaled corticosteroids fluticasone propionate, triamcinolone acetonide, and flunisolide and oral prednisone on the hypothalamic-pituitary-adrenal axis in adult patients with asthma.

Author: EdwardsL, LaForceC, LincourtW R, RogenesP R, SorknessC A, StormsW

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Inhaled corticosteroids are commonly used to treat asthma. This study investigated the effects of four weeks of treatment with inhaled corticosteroids on hypothalamic-pituitary-adrenal (HPA) axis function in patients with mild-to-moderate persistent asthma. Results showed that therapeutic doses of fluticasone propionate, triamcinolone acetonide, and flunisolide did not suppress adrenal function, while prednisone significantly suppressed HPA-axis function.
Paper Details　
Original Abstract of the Article :
Two multicenter, randomized, double-masked, placebo-controlled, parallel-group studies were conducted in adult patients with mild-to-moderate persistent asthma to assess the effects of 4 weeks of treatment with inhaled corticosteroids on hypothalamic-pituitary-adrenal (HPA) axis function. The first ...See full text at original site
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引用元：
https://doi.org/10.1016/S0149-2918(00)88292-2

データ提供：米国国立医学図書館（NLM）

Inhaled Corticosteroids: Navigating the Desert of HPA Axis Effects

The field of inhaled corticosteroids research often feels like a desert of complex interactions, particularly concerning their effects on the hypothalamic-pituitary-adrenal (HPA) axis. This study aimed to clarify the impact of different inhaled corticosteroids on HPA axis function in adult patients with asthma. The authors conducted two randomized, double-masked, placebo-controlled studies, comparing the effects of fluticasone propionate, triamcinolone acetonide, flunisolide, and oral prednisone.

Inhaled Corticosteroids: A Balanced Approach in the Asthma Desert

The research found that therapeutic doses of fluticasone propionate, triamcinolone acetonide, and flunisolide did not significantly suppress HPA axis function, suggesting that these inhaled corticosteroids have minimal systemic effects. However, prednisone produced significantly greater suppression of HPA axis function than any of the inhaled corticosteroids or placebo, highlighting the potential risks associated with oral prednisone use.

Health Implications

The study provides valuable information for clinicians in managing asthma patients, allowing them to choose the most appropriate corticosteroid treatment based on individual needs and potential risks. While inhaled corticosteroids offer a relatively safe option for managing asthma, it is crucial to be aware of potential HPA axis suppression and consult with your healthcare provider for individualized care.

Dr.Camel's Conclusion

This research navigates the complex landscape of inhaled corticosteroids and their effects on the HPA axis. The findings offer valuable guidance for clinicians in choosing the safest and most effective treatment for patients with asthma. The study highlights the importance of considering individual patient factors and weighing the potential benefits and risks of different corticosteroid options.

Date :
  1. Date Completed 1999-05-25
  2. Date Revised 2021-09-01
Further Info :

Pubmed ID

10211538

DOI: Digital Object Identifier

10.1016/S0149-2918(00)88292-2

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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