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A comparison of dicloxacillin and ampicillin in the antibiotic prophylaxis of total hip replacement.

Author: AntilaP, LaurentL E, VisuriT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.

Overview

Dicloxacillin was found to be more effective than ampicillin in preventing staphylococcal infections in patients undergoing total hip replacement.
Paper Details　
Original Abstract of the Article :
The effect of two semi-synthetic penicillins, dicloxacillin and ampicillin was compared in systemic antibiotic prophylaxis in total hip replacement patients. The drugs were given in routine oral dosage for eight days to two patient groups each consisting of 50 patients. There was no fatality. In the...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1032878

データ提供：米国国立医学図書館（NLM）

Dicloxacillin vs. Ampicillin for Antibiotic Prophylaxis in Total Hip Replacement: A Tale of Two Penicillins

Total hip replacement surgery is a common procedure, but it carries a risk of infection. This study compared the effectiveness of two semi-synthetic penicillins, dicloxacillin and ampicillin, in preventing infections after total hip replacement surgery. The researchers divided 100 patients into two groups, each receiving one of the antibiotics for eight days. They then analyzed the incidence of infections and side effects in each group.

Dicloxacillin Shows Superior Performance in Preventing Infections

The results of this study demonstrated a clear advantage of dicloxacillin over ampicillin in preventing staphylococcal infections after total hip replacement surgery. While three staphylococcal infections occurred in the ampicillin group, none were observed in the dicloxacillin group. These findings suggest that dicloxacillin may be a more effective choice for antibiotic prophylaxis in this surgical setting.

Choosing the Right Antibiotic for Total Hip Replacement

This study emphasizes the importance of choosing the right antibiotic for antibiotic prophylaxis in total hip replacement surgery. The authors demonstrate that dicloxacillin may offer superior protection against staphylococcal infections, which are a significant concern in this surgical setting. The study encourages healthcare professionals to consider this evidence when making decisions about antibiotic prophylaxis for total hip replacement patients.

Dr. Camel's Conclusion

Navigating the world of antibiotics can be like traversing a desert, where the right choice can mean the difference between success and failure. This study sheds light on the effectiveness of different antibiotics for preventing infections after total hip replacement surgery, highlighting the importance of carefully selecting the right medication to ensure patient safety and optimal outcomes.

Date :
  1. Date Completed 1978-08-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1032878

DOI: Digital Object Identifier

1032878

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in preparation
Languages

English

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