Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy.

Author: ChoR, JonesC, KapurS, McKayG, ZipurskyR B

Paper Details 
Original Abstract of the Article :
All currently available atypical antipsychotics have, at clinically relevant doses: i) high serotonin (5-HT)2 occupancy; ii) greater 5-HT2 than dopamine (D)2 occupancy; and iii) a higher incidence of extrapyramidal side effects when their D2 occupancy exceeds 80%. A review of pharmacologic and behav...See full text at original site
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引用元:
https://doi.org/10.1016/s0006-3223(98)00204-2

データ提供:米国国立医学図書館(NLM)

Delving into the Neurobiology of Amoxapine: Atypical Antipsychotic or Not?

The world of [psychiatry] is always looking for new ways to understand and treat [mental illness]. This study examines the [neurochemical properties] of [amoxapine], a medication used to treat [depression] and [psychosis], to see if it qualifies as an [atypical antipsychotic]. It's like carefully examining a desert flower, seeking clues to its unique properties.

Unveiling the Neurochemical Profile of Amoxapine

The study utilized [positron-emission tomography (PET)] to investigate how [amoxapine] interacts with [dopamine (D)2] and [serotonin (5-HT)2] receptors in the brain. The results show that [amoxapine] shares some characteristics with [atypical antipsychotics] but also exhibits some differences. It's like discovering a new desert plant that has some familiar traits but also some unique characteristics.

A Deeper Understanding of Antipsychotic Medications: A Journey of Exploration

This study is a valuable step in understanding the [neurobiology] of [amoxapine] and its potential role in the treatment of [mental illness]. It's a reminder that [medical research] is an ongoing journey of exploration, seeking to unlock the mysteries of the human brain and improve patient care. It's like embarking on a journey through a vast and complex desert, seeking knowledge and understanding along the way.

Dr. Camel's Conclusion

This study adds to our knowledge of the [neurochemical mechanisms] involved in [mental illness] and the potential role of [amoxapine] in treating these conditions. It's a reminder that the world of [psychiatry] is a dynamic field, where ongoing research and exploration are key to finding new solutions and improving patient outcomes. The desert of [mental illness] is vast and complex, but with continued research and understanding, we can find new oases of hope and healing.

Date :
  1. Date Completed 2000-01-05
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

10331115

DOI: Digital Object Identifier

10.1016/s0006-3223(98)00204-2

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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