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A randomized, double-blind comparison of risedronate and etidronate in the treatment of Paget's disease of bone. Paget's Risedronate/Etidronate Study Group.

Author: AxelrodD W, BekkerP J, BrownJ P, HoseyniM S, MillerP D, SirisE S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study found that risedronate was more effective than etidronate in treating Paget's disease of bone. It offered a shorter duration of therapy, better and longer-lasting remission, significant reductions in pain, and provided additional remission in subjects with incomplete response to previous etidronate treatment.
Paper Details　
Original Abstract of the Article :
PURPOSE: To compare the efficacy and tolerability of oral risedronate and etidronate for treatment of Paget's disease of bone. PATIENTS AND METHODS: Patients from 12 centers in North America received risedronate 30 mg daily for 2 months (62 patients) or etidronate 400 mg daily for 6 months (61 pati...See full text at original site
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引用元：
https://doi.org/10.1016/s0002-9343(99)00062-5

データ提供：米国国立医学図書館（NLM）

Alosetron for Irritable Bowel Syndrome: A Desert Oasis or a False Promise?

The [gastrointestinal system] is a complex and sensitive desert, prone to imbalances that can lead to conditions like [irritable bowel syndrome] (IBS). This study explores the effects of [alosetron], a [5-HT3-receptor antagonist], on [gastrointestinal transit] and [rectal sensation] in patients with [IBS].

The researchers conducted a [double-blind, placebo-controlled, two-dose study] in [25 patients] with [IBS] and found that [alosetron] had no significant effects on [gastrointestinal transit] or [rectal sensation] compared to [placebo]. These findings suggest that [alosetron] may not be an effective treatment for all [IBS] patients.

Exploring the Desert of IBS: A Camel's Perspective

As a camel, I've learned that finding the right oasis in the desert of [IBS] can be a challenging journey. This study reminds us that what works for one traveler may not work for another, and the search for effective treatments for [IBS] continues.

Dr.Camel's Conclusion

This study found that alosetron had no significant effect on gastrointestinal transit or rectal sensation in non-constipated irritable bowel syndrome patients. Further research is needed to evaluate the potential role of alosetron in the management of IBS and to explore its effects on colonic sensorimotor function and central sensory mechanisms.

Date :
  1. Date Completed 1999-06-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

10335722

DOI: Digital Object Identifier

10.1016/s0002-9343(99)00062-5

Related Literature

Article Analysis
・Effective treatment of paget's disease of bone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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