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Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

Author: GernerE W, MeyskensF L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

DFMO is an inhibitor of ornithine decarboxylase, an enzyme involved in polyamine synthesis. DFMO is being investigated as a potential chemopreventive agent for various cancers.
Paper Details　
Original Abstract of the Article :
D,L-alpha-difluoromethylornithine (DFMO) was synthesized over 20 years ago. It was hoped that this enzyme-activated, irreversible inhibitor of ornithine decarboxylase, the first enzyme in polyamine synthesis, would be effective as a chemotherapy for hyperproliferative diseases, including cancer and/...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10353725

データ提供：米国国立医学図書館（NLM）

The Potential of DFMO as a Cancer Chemoprevention Agent

The realm of cancer research is a vast and sandy desert, filled with endless possibilities and challenges. We, as researchers, are constantly searching for oases of knowledge that can lead us to better treatments and preventative measures. This research delves into the intriguing world of DFMO, a promising chemoprevention agent. The study used [research method] to investigate the potential of DFMO to inhibit cancer development in [study subjects]. The authors discovered that DFMO, a potent inhibitor of ornithine decarboxylase, can effectively suppress carcinogen-induced cancer development in various rodent models. This finding is particularly promising as it suggests that DFMO could potentially play a key role in preventing cancer in humans.

DFMO's Role in Cancer Prevention

This study provides valuable insights into the potential of DFMO as a cancer chemoprevention agent. The researchers found that DFMO, when administered in [dose and duration], can effectively suppress polyamine contents in gastrointestinal and other epithelial tissues, without causing any significant adverse effects. This finding highlights the potential of DFMO as a safe and effective tool for preventing cancer development in high-risk individuals.

DFMO and Cancer Prevention: A Promising Future

The research suggests that DFMO could be a valuable addition to our arsenal of cancer prevention strategies. Its ability to inhibit carcinogen-induced cancer development, combined with its favorable safety profile, makes it a promising candidate for future clinical trials. This research opens up a new avenue for exploring the potential of DFMO as a preventive agent.

Dr.Camel's Conclusion

The findings of this research offer a glimmer of hope in the vast desert of cancer research. DFMO's potential as a chemoprevention agent is a beacon of promise, offering a potential oasis for those at risk of developing cancer. While further research is needed to confirm these findings in humans, this study provides valuable insights into the potential of DFMO as a cancer prevention tool.

Date :
  1. Date Completed 1999-07-30
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

10353725

DOI: Digital Object Identifier

10353725

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Languages

English

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