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Oral versus transdermal selegiline: antidepressant-like activity in rats.
Author: AzzaroA J, GordonM N, MorganD G, MullerC D, ShermanK A, WeckerL
Original Abstract of the Article :
These studies compared the dose-response effects of oral vs. transdermal selegiline on antidepressant-like activity and brain monoamine oxidase (MAO) activities in rats. Rats received selegiline by gavage (0-100 mg/kg) or via transdermal patches (0-4.8 cm2, 0-8.7 mg/kg) daily for 7 days; antidepress...See full text at original site
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引用元:
https://doi.org/10.1016/s0091-3057(99)00016-7
データ提供:米国国立医学図書館(NLM)
Oral vs. Transdermal Selegiline: A Comparative Study
Depression, a common mental health challenge, affects millions worldwide. This study explores the effectiveness of selegiline, a medication used to treat depression, when administered through different routes: orally and transdermally. The researchers investigated the antidepressant-like activity of selegiline in rats, comparing the effects of oral and transdermal administration.
Exploring the Potential of Transdermal Selegiline
The study found that both oral and transdermal selegiline demonstrated antidepressant-like activity in rats. However, transdermal administration, which bypasses first-pass metabolism, allowed for using lower doses than oral administration. This finding suggests that transdermal selegiline may be a promising alternative for patients seeking a more effective and potentially safer treatment option for depression.
Finding the Right Path to Relief in the Desert of Depression
This study highlights the importance of exploring different treatment options and delivery methods to find the most effective approach for individual patients. Like a resourceful traveler navigating a vast desert, researchers are constantly seeking new pathways and solutions to improve treatment outcomes for depression.
Dr.Camel's Conclusion
This study, like a seasoned traveler sharing valuable insights about different routes through the desert of depression, provides a comprehensive analysis of oral and transdermal selegiline. The research offers hope for developing more effective and personalized treatment strategies for individuals struggling with this challenging mental health condition.
Date :
- Date Completed 1999-09-14
- Date Revised 2022-03-11
Further Info :
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