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Zaleplon and triazolam in humans: acute behavioral effects and abuse potential.

Author: FreyJ M, GriffithsR R, RushC R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Zaleplon, a hypnotic drug, produced comparable dose-related effects on several subject-rated drug-effect questionnaires and performance tasks to triazolam, a triazolobenzodiazepine hypnotic.
Paper Details　
Original Abstract of the Article :
Zaleplon, a pyrazolopyrimidine that is under development as a hypnotic, produces its pharmacological effects at the benzodiazepine-recognition site on the GABA(A) benzodiazepine-receptor complex. Unlike most benzodiazepines, zaleplon binds selectively to the BZ1 (omega1) subtype of the benzodiazepin...See full text at original site
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引用元：
https://doi.org/10.1007/s002130051030

データ提供：米国国立医学図書館（NLM）

Zaleplon and Triazolam: Comparing Hypnotics

The quest for effective and safe sleep medications is an ongoing journey in the field of medicine. This research compares the effects of zaleplon and triazolam, two hypnotic drugs, on healthy individuals with a history of drug abuse. The study, which was conducted using a double-blind, crossover design, examined various aspects of the drugs, including subject-rated effects, performance-impairing effects, and abuse potential. The findings indicate that both drugs produced similar effects in terms of subjective experience, performance impairment, and abuse potential, although the onset, peak, and duration of action differed.

Zaleplon and Triazolam: Similarities and Differences

The study found that both zaleplon and triazolam produced similar effects on subjective experiences, performance, and abuse potential. However, zaleplon's effects were more rapid and shorter in duration than triazolam's. This information is valuable for clinicians considering these drugs for their patients.

Understanding the Effects of Hypnotics

It is important to be aware of the potential side effects and risks associated with hypnotic medications, including impaired performance and potential for abuse. Consulting with a healthcare professional to determine the appropriate medication and dosage is essential for safe and effective use.

Dr.Camel's Conclusion

This research provides valuable insights into the comparative effects of zaleplon and triazolam. While both drugs exhibit similar effects, their different time-action profiles may influence their suitability for different patients and clinical situations.

Date :
  1. Date Completed 1999-09-14
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

10445371

DOI: Digital Object Identifier

10.1007/s002130051030

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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