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Novel hypotensive agents from Verbesina caracasana. 6. Synthesis and pharmacology of caracasandiamide.

Author: BottaB, BottaM, CarmignaniM, CorelliF, De BonnevauxS C, De LucaC, Delle MonacheF, EspinalR, MonacheG D, RipantiG, TafiA, VolpeA R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Caracasandiamide, a cyclobutane dimer isolated from Verbesina caracasana, has hypotensive and antihypertensive effects. It does not affect heart rate and does not have significant actions on the central nervous system or baroreflex pathways. Caracasandiamide may be considered a more effective hypotensive and antihypertensive drug than caracasanamide with fewer negative side effects.
Paper Details　
Original Abstract of the Article :
Caracasandiamide, a second hypotensive agent isolated from Verbesina caracasana, is the cyclobutane dimer (truxinic type) of the previously reported 1-[(3, 4-dimethoxycinnamoyl)amino]-4-[(3-methyl-2-butenyl)guanidino]butane (caracasanamide) (Delle Monache, G.; et al. BioMed. Chem. Lett. 1992, 25, 41...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10447956

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of the Desert Plant: Verbesina caracasana

The desert is a treasure trove of natural wonders, offering a rich tapestry of flora and fauna with unique properties. This study, like a botanical expedition through this landscape, explores the hypotensive potential of a compound derived from the plant Verbesina caracasana. The study aimed to understand the pharmacological effects of caracasandiamide, a cyclobutane dimer isolated from this plant.

Caracasandiamide: A Potential Oasis for Hypertension

The study revealed that caracasandiamide had a complex effect on the cardiovascular system, with the ability to both increase and decrease blood pressure depending on the dose. At lower doses, it stimulated breathing and increased cardiac inotropism, while at higher doses, it induced hypotension by reducing peripheral vascular resistance. These findings suggest that caracasandiamide, like a carefully balanced ecosystem in the desert, has a complex and potentially beneficial effect on blood pressure regulation.

A New Path for Hypertension Management

This study offers a glimpse into the potential of natural compounds for managing hypertension. Caracasandiamide, derived from a desert plant, holds promise as a novel hypotensive agent, potentially offering a new approach for treating this prevalent condition. Further research is needed to fully understand its therapeutic potential and explore its potential applications in human health.

Dr.Camel's Conclusion

This study, like a journey through the desert, unveils the hidden potential of Verbesina caracasana. Caracasandiamide, a compound derived from this plant, shows promise as a novel hypotensive agent, potentially offering a new path for managing hypertension. This research underscores the importance of exploring the diverse world of natural compounds for their potential therapeutic benefits, reminding us that even in the harshest landscapes, valuable discoveries can be found.

Date :
  1. Date Completed 1999-09-02
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

10447956

DOI: Digital Object Identifier

jm991004l

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