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Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.

Author: AsfahaS, ChapmanK, Del SoldatoP, FiorucciS, McKnightW, MorelliA, MuscaráM N, VergnolleN, WallaceJ L

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A nitric oxide (NO)-releasing derivative of mesalamine, NCX-456 (NO-mesalamine), was significantly more effective than mesalamine in reducing the severity of colitis in a rat model. NO-mesalamine suppressed leukocyte adherence to the vascular endothelium in vivo and inhibited interleukin (IL)-1beta and interferon (IFN)-gamma release and caspase 1 activity in splenocytes.
Paper Details　
Original Abstract of the Article :
BACKGROUND & AIMS: Nitric oxide (NO)-releasing derivatives of cyclooxygenase inhibitors exhibit enhanced anti-inflammatory activity and greatly reduced gastrointestinal toxicity. We evaluated whether a similar derivatization of mesalamine (5-aminosalicylic acid) would improve its anti-inflammatory a...See full text at original site
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引用元：
https://doi.org/10.1016/s0016-5085(99)70448-8

データ提供：米国国立医学図書館（NLM）

Boosting Mesalamine's Power: Nitric Oxide for Inflammation Relief

This research investigates the potential of nitric oxide (NO)-releasing derivatives of mesalamine, a drug used to treat inflammatory bowel disease (IBD), to enhance its anti-inflammatory activity. The study explores the effects of an NO-releasing derivative of mesalamine (NCX-456) in a rat model of colitis.

Nitric Oxide: A Potential Game Changer for IBD

The study found that the NO-releasing derivative of mesalamine was significantly more effective than mesalamine alone in reducing colitis severity, indicating that the addition of NO may enhance the drug's anti-inflammatory effects. These findings suggest that NO-releasing derivatives of mesalamine may offer a promising new approach to treating IBD.

Fighting Inflammation: A Desert Oasis for Gut Health

Imagine a desert traveler suffering from a severe sandstorm, a metaphor for the inflammation and discomfort experienced by those with IBD. This research explores the potential of nitric oxide to calm the storm, providing relief and promoting gut health. This study offers hope for a new approach to treating IBD and alleviating the suffering caused by this debilitating disease.

Dr.Camel's Conclusion

This research highlights the potential of NO-releasing derivatives of mesalamine to enhance anti-inflammatory activity and offers a promising new avenue for treating IBD. Like a desert oasis providing relief from the heat, this innovative approach could offer a much-needed respite for those suffering from chronic inflammation in their gut.

Date :
  1. Date Completed 1999-09-16
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

10464131

DOI: Digital Object Identifier

10.1016/s0016-5085(99)70448-8

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SNS
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in preparation
Languages

English

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