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Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men.

Author: ChittickG E, CrouchM A, GouldinW, IsraelD S, LouY, PastorA, PolkR E, SadlerB M, SymondsW T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Coadministration of ketoconazole and amprenavir resulted in a statistically significant increase in AUC for both agents, but the changes were not likely to be clinically important.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: To determine the effects of coadministration of amprenavir and ketoconazole on the pharmacokinetics of both drugs, and to assess the utility of the erythromycin breath test (ERMBT) to predict and explain these effects. DESIGN: Open-label, randomized, balanced, single-dose, three-pe...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1592/phco.19.18.1378.30905

データ提供：米国国立医学図書館（NLM）

The Intricate Dance of Drugs: Ketoconazole and Amprenavir

The world of [pharmacokinetic interactions] is like a complex dance in the desert, with each drug playing a unique role and influencing the others. This research examines the [interaction between ketoconazole and amprenavir], two medications often used for [HIV treatment]. The study explored the [effects of coadministration] on the [pharmacokinetics] of both drugs using a [single-dose, three-period crossover study] design.

Understanding the Impact of Coadministration

The study revealed that [coadministration of ketoconazole and amprenavir] resulted in [statistically significant increases in AUC for both agents]. While these changes were considered [not clinically important], the research highlights the importance of [understanding drug interactions] to ensure patient safety and optimal treatment outcomes. It's like observing the intricate dance of sand dunes – each drug's behavior is influenced by the presence of the other.

Navigating the Desert of Medications

This research reminds us that even seemingly straightforward medications can interact in complex ways, just like the shifting sands of a desert. Understanding the [potential for drug interactions] is crucial for healthcare professionals to ensure the safety and effectiveness of patient treatments.

Dr.Camel's Conclusion

This study reminds us that the world of medications is like a vast and unpredictable desert. By understanding the [complex interactions] between drugs, we can navigate this landscape more effectively, ensuring the safety and well-being of those seeking treatment.

Date :
  1. Date Completed 2000-01-07
  2. Date Revised 2020-12-08
Further Info :

Pubmed ID

10600086

DOI: Digital Object Identifier

10.1592/phco.19.18.1378.30905

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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