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Targeting the HIV-protease in AIDS therapy: a current clinical perspective.

Author: HeinriksonR L, TomasselliA G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the clinical applications of HIV protease inhibitors. These drugs are effective in the treatment of AIDS but can cause viral resistance and side effects.
Paper Details　
Original Abstract of the Article :
This review deals with clinical applications of compounds that inhibit the action of the protease encoded within the genome of human immunodeficiency virus (HIV). The HIV-protease is essential for viral maturation and represents an important therapeutic target in the fight against AIDS. Following a ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/s0167-4838(99)00273-3

データ提供：米国国立医学図書館（NLM）

HIV Protease Inhibitors: A Powerful Weapon in the Fight Against AIDS

This research takes us on a journey through the complex world of HIV protease inhibitors, a vital class of drugs used to combat the devastating effects of AIDS. The study dives into the clinical applications of these inhibitors, which target the HIV protease enzyme, a critical player in the virus's maturation process. The researchers shed light on the mechanisms of action of various peptide and non-peptide-based HIV protease inhibitors currently employed in clinical practice. They also explore the challenges associated with these drugs, including the emergence of viral resistance and potential side effects. This research provides valuable insights into the effectiveness and limitations of HIV protease inhibitors, paving the way for further advancements in the treatment of AIDS.

Understanding the Challenges of HIV Protease Inhibitors

The study highlights the effectiveness of HIV protease inhibitors in combating AIDS. However, it also emphasizes the challenges posed by viral resistance and potential side effects. This underscores the need for continued research and development to overcome these obstacles and improve the lives of individuals living with HIV/AIDS.

Harnessing the Power of HIV Protease Inhibitors

This research provides a comprehensive overview of HIV protease inhibitors, a critical component of the fight against AIDS. By understanding the mechanisms of action, benefits, and challenges associated with these drugs, healthcare professionals can effectively manage HIV/AIDS and improve patient outcomes.

Dr.Camel's Conclusion

Fighting AIDS is like navigating a treacherous desert storm. HIV protease inhibitors are like sturdy camels, providing strength and support to those affected by this devastating disease. However, just as a caravan must be prepared for unforeseen challenges, we must continue to research and develop new strategies to overcome viral resistance and minimize side effects.
Date :
  1. Date Completed 2000-05-24
  2. Date Revised 2020-12-08
Further Info :

Pubmed ID

10708858

DOI: Digital Object Identifier

10.1016/s0167-4838(99)00273-3

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Languages

English

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