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Phase I pharmacologic study of oral topotecan and intravenous cisplatin: sequence-dependent hematologic side effects.

Author: BrouwerE, DoyleE, GelderblomH, HearnS, LoosW J, MantelM A, PlantingA S, RossG, SparreboomA, VerweijJ, de JongeM J, van BeurdenV, van der BurgM E

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

This phase I study assessed the feasibility of combining oral topotecan and cisplatin.
Paper Details　
Original Abstract of the Article :
In in vitro studies, synergism and sequence-dependent effects were reported for the combination of topotecan and cisplatin. Recently, an oral formulation of topotecan became available. This phase I study was performed to assess the feasibility of the combination of oral topotecan and cisplatin, the ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1200/JCO.2000.18.10.2104

データ提供：米国国立医学図書館（NLM）

The Dance of Drugs: Exploring the Synergy of Topotecan and Cisplatin

This research investigates the potential of a combination therapy involving [topotecan] and [cisplatin] to combat [cancer]. It's like a well-rehearsed dance between two desert nomads; each step and movement is crucial for success. The study explores the [pharmacokinetic interaction] and potential [sequence-dependent effects] of this drug combination, hoping to find the perfect rhythm for optimal treatment.

A New Rhythm in the Desert of Cancer Treatment

This research explores the possibility of harnessing the power of combination therapies to [treat cancer] more effectively. It's like discovering a new oasis in the vast desert of cancer research, offering hope for improved treatment outcomes.

Navigating the Desert of Cancer Treatment: A Symphony of Therapies

This research is a reminder that cancer treatment often requires a multi-faceted approach, just like a symphony with many instruments playing together. It's essential to carefully consider the potential benefits and risks of different therapies and to work with a healthcare professional to find the best treatment plan for each individual.

Dr.Camel's Conclusion

This research highlights the importance of exploring new combinations of therapies to improve cancer treatment. It's like finding a new melody in the vast desert of cancer research, offering hope for more effective and less toxic treatment options.

Date :
  1. Date Completed 2000-06-15
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

10811676

DOI: Digital Object Identifier

10.1200/JCO.2000.18.10.2104

Related Literature

Article Analysis
・Effects of topotecan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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