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Maximum urine concentrating ability in children with Hb SC disease: effects of hydroxyurea.

Author: BaligaR, BrugnaraC, HoganS, IyerR, KirchnerK, NagelR L, SteinbergM H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Hydroxyurea was not associated with increased urine concentrating ability in children with Hb SC disease.
Paper Details　
Original Abstract of the Article :
Studies in adults with Hb SC disease suggested that hydroxyurea reduced hemolysis and increased red cell hydration. Because increased hydration should diminish the polymerization tendency of Hb S we hypothesized that hydroxyurea might repair the urine concentration defect of HbSC disease. Eight Hb S...See full text at original site
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引用元：
https://doi.org/10.1002/(sici)1096-8652(200005)64:1<47::aid-ajh8>3.0.co;2-1

データ提供：米国国立医学図書館（NLM）

Hydroxyurea and Urine Concentration Ability in Children with Hb SC Disease

In the vast desert of pediatric hematology, we encounter a variety of challenges. This research focuses on sickle cell anemia, a genetic blood disorder characterized by abnormal red blood cells. The study investigates the effects of hydroxyurea, a medication used to treat sickle cell anemia, on urine concentrating ability in children with Hb SC disease, a milder form of sickle cell anemia.

Hydroxyurea's Effects on Urine Concentration

The study explores whether hydroxyurea improves urine concentration ability in children with Hb SC disease. This is like testing a new irrigation system in the desert, hoping it can restore the flow of water and revitalize the oasis. The researchers found no evidence that hydroxyurea improved urine concentrating ability in children with Hb SC disease, suggesting that other factors might be responsible for impaired renal function in this population.

Implications for Hb SC Disease Management

This research provides valuable insights into the management of Hb SC disease. While hydroxyurea has been shown to improve other aspects of the disease, its impact on urine concentrating ability remains unclear. Further research is needed to understand the underlying mechanisms of renal dysfunction in Hb SC disease and to identify potential interventions to address this issue.

Dr. Camel's Conclusion

This research sheds light on the complex interplay between hydroxyurea treatment and renal function in children with Hb SC disease. While the study suggests that hydroxyurea may not directly improve urine concentrating ability, it highlights the need for further investigation into the underlying causes and potential treatments for renal dysfunction in this population.
Date :
  1. Date Completed 2000-05-31
  2. Date Revised 2019-08-22
Further Info :

Pubmed ID

10815787

DOI: Digital Object Identifier

10.1002/(sici)1096-8652(200005)64:1<47::aid-ajh8>3.0.co;2-1

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Article Analysis
・Effects of hydroxyurea
SNS
PICO Info
in preparation
Languages

English

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