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Cutaneous side effects induced by indinavir.

Author: BoschiniA, CalistaD

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Indinavir, an HIV protease inhibitor, was associated with various cutaneous side effects, including cheilitis, dryness, pruritus, and alopecia in 84 patients. These effects regressed after discontinuation of indinavir, highlighting the need for multidisciplinary management of cutaneous toxicity associated with protease inhibitors.
Paper Details　
Original Abstract of the Article :
HIV-protease inhibitors demonstrated such high efficacy in short-term studies that they have been approved by the FDA, even though possible toxicity still needs further investigation. In the period between January 1997 and August 1998, 101 patients, staying at San Patrignano Medical Centre (Italy), ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10846257

データ提供：米国国立医学図書館（NLM）

Cutaneous Side Effects of Indinavir

HIV protease inhibitors have revolutionized the treatment of HIV infection, but they can also cause significant side effects, including skin problems. This study investigated the cutaneous side effects associated with indinavir, a commonly used protease inhibitor. The researchers observed a large cohort of HIV patients who received indinavir as part of their treatment regimen.

Cutaneous Side Effects of Indinavir

The study found that a significant proportion of patients receiving indinavir developed various cutaneous side effects, including cheilitis, cutaneous dryness, pruritus, asteatotic dermatitis, scalp defluvium, and alopecia. Peripheral lipodystrophy syndrome, a condition characterized by fat redistribution, was also observed in some patients. These side effects typically resolved after discontinuation of indinavir, suggesting a causal relationship.

Managing Cutaneous Side Effects

The study highlights the importance of managing cutaneous side effects associated with HIV protease inhibitors. A multidisciplinary approach involving dermatologists and other healthcare professionals is crucial to diagnose and treat these skin problems, improve patient quality of life, and maintain treatment adherence.

Dr.Camel's Conclusion

Just as a camel's skin provides protection in the harsh desert, our skin is essential for our health and well-being. This study reminds us that even life-saving medications can come with side effects, and it's vital to be aware of and address these potential complications.

Date :
  1. Date Completed 2000-08-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10846257

DOI: Digital Object Identifier

10846257

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Languages

English

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