Paper Details 
Original Abstract of the Article :
We have immobilized the mineralizing agent alkaline phosphatase (AlkP) in a hydrophilic polymer (poly 2(hydroxyéthyl) methacrylate) (pHEMA) in a copolymerization technique. Histochemical study on polymer sections revealed that AlkP has retained its biological activity. The image analysis of sections...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/10923337

データ提供:米国国立医学図書館(NLM)

The Mineralization Puzzle: A New Approach to Bone and Cartilage Research

This study delves into the fascinating world of bone and cartilage mineralization, exploring the complex interactions between various molecules and their influence on the formation of mineral deposits. The study utilizes a novel system, immobilizing alkaline phosphatase (AlkP), an enzyme crucial for mineralization, within a hydrophilic polymer. This innovative approach allows researchers to study the effects of bisphosphonates, a class of drugs used to treat bone diseases, on the mineralization process, offering valuable insights into bone and cartilage formation.

Bisphosphonates: A Key to Understanding Bone and Cartilage Formation

The study reveals the inhibitory effects of bisphosphonates on AlkP activity and the subsequent formation of mineral deposits, providing valuable insights into their mechanism of action and their role in bone and cartilage metabolism. This research sheds light on the intricate interplay of molecules and their impact on the formation of bone and cartilage, paving the way for a better understanding of bone diseases and the development of more effective treatments.

Unraveling the Mysteries of Bone and Cartilage: A Journey Towards Healthier Bones

This study offers a glimpse into the intricate world of bone and cartilage mineralization, providing valuable insights into the mechanisms of action of bisphosphonates and their role in bone health. This research is essential for understanding the complexities of bone and cartilage diseases and developing innovative approaches to maintain healthy bones throughout life.

Dr.Camel's Conclusion

This study sheds light on the fascinating world of bone and cartilage mineralization, utilizing a novel system to investigate the effects of bisphosphonates on this crucial process. The findings provide valuable insights into the mechanism of action of these drugs and their role in bone health, paving the way for a better understanding of bone and cartilage diseases and the development of more effective treatments.

Date :
  1. Date Completed 2000-09-12
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

10923337

DOI: Digital Object Identifier

10923337

Related Literature

SNS
PICO Info
in preparation
Languages

French

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