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Phosphorylation of AZT-resistant human immunodeficiency virus type 1 reverse transcriptase by casein kinase II in vitro: effects on inhibitor sensitivity.
Author: BorettoJ, CanardB, CaponyJ P, LazaroJ B, SelmiB
Original Abstract of the Article :
Casein kinase II (CKII) phosphorylates wild-type (WT) recombinant reverse transcriptase (RT) mainly in the p66 subunit in vitro. Phosphorylation of T215F RT and D67N/K70R/T215F/K219Q RT (AZT-resistant RT) in vitro increases discrimination against AZTTP 2. 5- and 3.6-fold, respectively. This in vitro...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/10944435
データ提供:米国国立医学図書館(NLM)
Phosphorylation of Reverse Transcriptase: A Potential Factor in HIV Drug Resistance
Human immunodeficiency virus (HIV) reverse transcriptase (RT) is a key enzyme involved in HIV replication. This study investigates the role of phosphorylation of RT in the development of drug resistance, particularly against the antiretroviral drug AZT. Like a curious camel investigating the hidden secrets of the desert, this research explores the intricate mechanisms of drug resistance in HIV.
Phosphorylation and Drug Resistance
The researchers found that phosphorylation of AZT-resistant RT in vitro increased discrimination against AZTTP, a derivative of AZT. This suggests that phosphorylation might play a role in the development of drug resistance. However, further research is needed to confirm this finding in vivo.
Implications for HIV Drug Resistance
This study raises important questions about the role of phosphorylation in HIV drug resistance. Understanding the mechanisms of drug resistance is crucial for developing new drugs and treatment strategies to combat HIV infection effectively.
Dr. Camel's Conclusion
This study delves into the complexities of HIV drug resistance, revealing the potential influence of phosphorylation on RT function. It highlights the ongoing need for research to understand the intricate interplay of molecular mechanisms and drug resistance in HIV infection.
Date :
- Date Completed 2000-09-21
- Date Revised 2021-12-03
Further Info :
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