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A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures.

Author: AldenkampA P, BakerG, ChadwickD, CooperP, DoelmanJ, DuncanR, Gassmann-MayerC, HughsonC, HulsmanJ, MulderO G, OverwegJ, PledgerG, RentmeesterT W, RiazH, WroeS, de HaanG J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Topiramate and valproate, two anticonvulsant medications, were compared for their cognitive effects when used as adjunctive therapy to carbamazepine. The study found that a more gradual introduction of topiramate improved tolerability and prevented cognitive impairment.
Paper Details　
Original Abstract of the Article :
This study compares the cognitive effects of topiramate (TPM) with those of valproate (VPA) using efficacious doses of each drug when used as adjunctive therapy to carbamazepine (CBZ). A key question of the study is to what extent a more gradual introduction of TPM improves tolerability and prevents...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1157.2000.tb00322.x

データ提供：米国国立医学図書館（NLM）

Topiramate vs. Valproate: Navigating the Cognitive Landscape of Epilepsy Treatment

Epilepsy, like a desert mirage, can be a challenging condition to manage. This study explores the cognitive effects of topiramate (TPM) and valproate (VPA) when used as add-on therapy to carbamazepine (CBZ) in patients with partial-onset seizures. The study aims to compare the cognitive impact of these two medications, seeking to optimize treatment while minimizing cognitive side effects.

Cognitive Effects: A Balancing Act in Epilepsy Treatment

The study investigates the cognitive effects of TPM and VPA, highlighting the potential benefits and challenges associated with each medication. The study also examines the impact of different dosing strategies on cognitive function.

Optimizing Epilepsy Treatment: A Quest for Cognitive Preservation

This study provides valuable insights into the complex relationship between antiepileptic medications and cognitive function. It emphasizes the importance of considering cognitive effects when selecting and adjusting medications for patients with epilepsy.

Dr. Camel's Conclusion

This study is like a desert expedition, carefully navigating the terrain of epilepsy treatment. It highlights the importance of considering the cognitive impact of medications, seeking to optimize seizure control while preserving cognitive function. The findings offer valuable insights for clinicians seeking to provide the best possible care for patients with epilepsy.

Date :
  1. Date Completed 2000-09-26
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

10999556

DOI: Digital Object Identifier

10.1111/j.1528-1157.2000.tb00322.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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