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The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease.

Author: CastellD O, KahrilasP J, QuigleyE M, SpechlerS J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Tegaserod, a 5-HT4 receptor partial agonist, significantly decreases postprandial oesophageal acid exposure in patients with mild-to-moderate GERD. A dose of 1 mg/day reduced acid exposure by 50% in the postprandial period. The reduction in acid exposure may be due to enhanced acid clearance, improved gastric emptying, and/or reduced transient lower oesophageal sphincter relaxations.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tegaserod (HTF 919), a 5-HT4 receptor partial agonist, has prokinetic effects that might be useful in decreasing acid reflux in gastro-oesophageal reflux disease (GERD). METHODS: To investigate the potential clinical utility of tegaserod in GERD, a five-period crossover study (balanced ...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.2000.00854.x

データ提供：米国国立医学図書館（NLM）

Tegaserod: A Potential Oasis in the Desert of GERD

Gastroesophageal reflux disease (GERD), a common digestive disorder, can feel like a burning desert of discomfort. This study explores the potential of tegaserod, a medication that stimulates the digestive system, to provide relief from the symptoms of GERD. It's like finding a cool spring in the desert of indigestion, offering a potential solution to ease the discomfort.

The study investigates the effects of tegaserod on oesophageal acid exposure, a key factor contributing to GERD symptoms. It's like examining the impact of a gentle breeze on a desert sandstorm, understanding how a medication can influence the flow of acid in the digestive system.

A Potential Solution in the Desert of GERD

The study found that tegaserod effectively reduced oesophageal acid exposure in patients with GERD. It's like discovering a hidden oasis in the desert of GERD, offering a potential respite from the discomfort of acid reflux.

Living with GERD

This research highlights the importance of managing GERD effectively to prevent long-term complications. It's a reminder that the desert of health requires constant vigilance and attention to the subtle signals of our bodies.

Dr. Camel's Conclusion

This research is a testament to the ongoing search for effective treatments for GERD. It's a reminder that the desert of healthcare is constantly evolving, offering new hope for those seeking relief from digestive discomfort.

Date :
  1. Date Completed 2000-12-20
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

11069322

DOI: Digital Object Identifier

10.1046/j.1365-2036.2000.00854.x

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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