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Rifampin decreases the plasma concentrations and effects of repaglinide.

Author: BackmanJ T, KivistöK T, NeuvonenM, NeuvonenP J, NiemiM

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rifampin significantly decreases the plasma concentrations and effects of repaglinide, a short-acting antidiabetic drug. In a study of nine healthy volunteers, rifampin reduced the area under the concentration-time curve of repaglinide by 57% and the peak concentration by 41%.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To study the effects of rifampin (INN, rifampicin) on the pharmacokinetics and pharmacodynamics of repaglinide, a new short-acting antidiabetic drug. METHODS: In a randomized, two-phase crossover study, nine healthy volunteers were given a 5-day pretreatment with 600 mg rifampin or match...See full text at original site
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引用元：
https://doi.org/10.1067/mcp.2000.111183

データ提供：米国国立医学図書館（NLM）

The Curious Case of Rifampin and Repaglinide

Rifampin is a powerful antibiotic commonly used to treat bacterial infections. Repaglinide is a medication used to control blood sugar levels in patients with type 2 diabetes. This research explores the potential interaction between these two drugs, focusing on how rifampin affects the pharmacokinetics and pharmacodynamics of repaglinide. The study found that rifampin significantly decreased the levels of repaglinide in the bloodstream and reduced its effectiveness in lowering blood sugar. This interaction is likely due to rifampin's ability to induce the metabolism of repaglinide. The research provides important insights into the potential for drug interactions and the need for careful monitoring when patients are taking multiple medications.

Understanding Drug Interactions

This study highlights the importance of considering potential drug interactions when prescribing medications. Rifampin's ability to induce the metabolism of other drugs can lead to a decrease in their effectiveness. Therefore, healthcare professionals need to be aware of these interactions and carefully monitor patients who are taking multiple medications. This is particularly important for individuals with chronic conditions, such as diabetes, who may be taking multiple medications long-term.

Managing Drug Interactions

If you are taking multiple medications, it is essential to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and herbal supplements. This allows your healthcare provider to assess potential drug interactions and make necessary adjustments to your medication regimen. By being proactive and communicating openly with your healthcare provider, you can help ensure the safety and effectiveness of your medications.

Dr.Camel's Conclusion

This research is a reminder that the desert of medicine is vast and complex, with many unseen interactions lurking between seemingly unrelated medications. Just as a camel must navigate treacherous landscapes, healthcare professionals must carefully consider these interactions to ensure the safety and efficacy of their patients' treatment.

Date :
  1. Date Completed 2000-12-22
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

11103752

DOI: Digital Object Identifier

10.1067/mcp.2000.111183

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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