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Side effects and time course of response in a placebo-controlled trial of fluoxetine for the treatment of geriatric depression.

Author: AckermanD L, BystritskyA, GreenlandS, SmallG W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study analyzed data from a clinical trial of fluoxetine for geriatric depression. Fluoxetine was superior to placebo, and early and persistent improvement occurred in both groups. Pretreatment somnolence was associated with early improvement and may serve as a marker for placebo response.
Paper Details　
Original Abstract of the Article :
A high rate of improvement among patients who receive placebo in controlled trials of antidepressants can complicate the evaluation of true drug effect. Placebo response may be a reaction to the psychosocial factors of study participation or a function of changes in the natural course of depression....See full text at original site
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引用元：
https://doi.org/10.1097/00004714-200012000-00012

データ提供：米国国立医学図書館（NLM）

Fluoxetine for Geriatric Depression: Side Effects and Time Course of Response

Depression, a common mental health condition, can be particularly challenging in older adults. This study examined the efficacy of fluoxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, in treating geriatric depression. The researchers reanalyzed data from a large, multicenter, placebo-controlled clinical trial of fluoxetine treatment for geriatric depression. They focused on evaluating similarities and differences between responders and nonresponders in both treatment groups, examining weekly somatic complaints as possible predictors of response and dropout, as well as the time course and onset of response.

Fluoxetine Shows Promise for Geriatric Depression

The study found that fluoxetine was superior to placebo in treating geriatric depression. The results suggest that fluoxetine can effectively alleviate depressive symptoms in older adults. The study also identified specific somatic complaints, such as headache and anxiety, that could potentially predict response to fluoxetine treatment.

Understanding Depression Treatment in Older Adults

This study provides valuable insights into the treatment of depression in older adults. While fluoxetine shows promise as a treatment option, it's important to consider individual patient factors and potential side effects. Consulting with a healthcare professional is crucial to develop a personalized treatment plan that addresses the unique needs of each patient.

Dr.Camel's Conclusion

Think of depression as a heavy sandstorm obscuring the path ahead for an aging camel. Fluoxetine, like a refreshing breeze, can help clear the storm, restoring clarity and vitality. This study helps us understand the nuances of depression treatment in older adults, reminding us that each camel's journey is unique, requiring tailored care and support. Remember, a little guidance can make a big difference in navigating the desert of depression.

Date :
  1. Date Completed 2001-05-31
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

11106138

DOI: Digital Object Identifier

10.1097/00004714-200012000-00012

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・Side Effects of fluoxetine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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