Paper Details

  1. Home
  2. Paper Details

Evaluation of the pharmacokinetics and electrocardiographic pharmacodynamics of loratadine with concomitant administration of ketoconazole or cimetidine.

Author: AffrimeM B, BatraV K, CayenM N, KosoglouT, LimJ M, SalfiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that ketoconazole or cimetidine significantly increased the plasma concentrations of loratadine and its metabolite, desloratadine, but did not change the QTc interval in healthy volunteers.
Paper Details　
Original Abstract of the Article :
AIMS: To evaluate whether ketoconazole or cimetidine alter the pharmacokinetics of loratadine, or its major metabolite, desloratadine (DCL), or alter the effects of loratadine or DCL on electrocardiographic repolarization in healthy adult volunteers. METHODS: Two randomized, evaluator-blind, multip...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1046/j.1365-2125.2000.00290.x

データ提供：米国国立医学図書館（NLM）

Loratadine, Ketoconazole, and Cimetidine: A Pharmacokinetic Dance

The human body is a complex system, a vast and intricate desert with many interconnected pathways. This study investigates the pharmacokinetic interactions between loratadine, an antihistamine, and two medications, ketoconazole and cimetidine, both known to affect the body’s ability to break down drugs. The researchers, equipped with their scientific tools, conducted two studies to evaluate the effects of co-administering loratadine with either ketoconazole or cimetidine.

No Change in Electrocardiogram

The study found that co-administration of loratadine with either ketoconazole or cimetidine led to increased levels of loratadine in the blood. However, despite these increased levels, there were no significant changes in electrocardiogram results, a measure of heart function. This finding suggests that, while the drug interactions did increase loratadine levels, they did not significantly affect the heart’s electrical activity.

Navigating the Desert of Drug Interactions

This study is like a guide for navigating the desert of drug interactions. It shows that even though drug interactions can occur, they may not always lead to significant side effects. However, it’s important to be aware of potential drug interactions and to consult with a healthcare provider if you’re taking multiple medications. This study reminds us to be mindful of the intricate pathways within our bodies and how various medications can interact with each other.

Dr.Camel's Conclusion

This research is like a camel navigating a complex desert landscape, revealing the intricate interplay of medications within the body. The study shows that even when drug interactions occur, they may not always lead to significant side effects. However, it’s important to be aware of potential interactions and to communicate openly with your healthcare provider about all the medications you are taking.
Date :
  1. Date Completed 2001-01-25
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

11136297

DOI: Digital Object Identifier

10.1046/j.1365-2125.2000.00290.x

Related Literature

Article Analysis
・Effects of loratadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.