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Tc-99m-PEG-Liposomes for the evaluation of colitis in Crohn's disease.

Author: BoermanO C, BrouwersA H, CorstensF H, DamsE T, De JongD J, LavermanP, NaberT H, OyenW J, StormG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

99mTc-PEG-liposome scintigraphy can be used to determine the extent of Crohn's colitis non-invasively. However, the study was prematurely terminated due to unacceptable side effects in 3 out of 9 patients, which consisted of dyspnea and facial erythema.
Paper Details　
Original Abstract of the Article :
In the present study, the potential role of 99mTc-PEG-liposome to determine the extent and severity of active disease of Crohn's colitis was investigated. Patients suspected of having an exacerbation of Crohn's disease underwent a 99mTc-PEG-liposome scan (740 MBq, imaging at 4 and 24 h p.i.). A bari...See full text at original site
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引用元：
https://doi.org/10.3109/10611860008997901

データ提供：米国国立医学図書館（NLM）

Tc-99m-PEG-Liposomes: Navigating the Complexities of Crohn's Disease

This research explores the potential of 99mTc-PEG-liposomes, a radioactive tracer, to help diagnose and assess the severity of Crohn's disease, an inflammatory bowel disorder. It's like using a compass to navigate the complex landscape of Crohn's disease, allowing clinicians to identify the extent and severity of the disease. The researchers aimed to evaluate the effectiveness of this tracer in imaging the inflamed areas of the colon, providing a more precise assessment of the disease.

Tc-99m-PEG-Liposomes: A Potential Compass in the Desert of Crohn's Disease

The researchers found that 99mTc-PEG-liposomes could be a valuable tool for visualizing inflamed areas of the colon in patients with Crohn's disease. It's like finding a hidden oasis in the desert, revealing the extent and severity of the disease. However, the study also noted some side effects that need to be addressed before this tracer can be widely used in clinical practice.

Improving Crohn's Disease Management

This research highlights the need for continued research to develop safe and effective diagnostic tools for Crohn's disease. It's like exploring a desert, searching for the best ways to map and understand the complex landscape of this disease. The study emphasizes the importance of careful evaluation and optimization of new diagnostic techniques before they are used in clinical practice.

Dr.Camel's Conclusion

This research offers a glimpse into the potential of 99mTc-PEG-liposomes as a diagnostic tool for Crohn's disease. It's like finding a new compass in the desert, offering a potentially valuable tool for navigating this complex disease. Further research is needed to address the side effects and optimize the use of this tracer, ensuring the safety and effectiveness of this diagnostic approach.

Date :
  1. Date Completed 2001-02-08
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11144233

DOI: Digital Object Identifier

10.3109/10611860008997901

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English

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