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Thioguanine for refractory psoriasis: a 4-year experience.

Author: KruegerG G, MasonC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that thioguanine was an effective treatment for patients with severe recalcitrant psoriasis. The primary side effect was myelosuppression, which can be more accurately predicted by determining thiopurine methyltransferase levels before starting treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A variety of systemically administered drugs are used to treat psoriasis, including methotrexate, cyclosporine, acitretin, and hydroxyurea. Unfortunately, some patients are unresponsive to these agents. For others, side effects and cumulative toxicity prevent continued use. OBJECTIVE: O...See full text at original site
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引用元：
https://doi.org/10.1067/mjd.2001.109296

データ提供：米国国立医学図書館（NLM）

Thioguanine: A Treatment for Refractory Psoriasis

In the vast landscape of [dermatology], psoriasis remains a challenging condition for many patients. This study explores the potential of [thioguanine] as a treatment option for individuals with refractory psoriasis, those who haven't responded to conventional therapies.

The researchers conducted a retrospective analysis of 21 patients with psoriasis who received thioguanine treatment. They observed remarkable improvement in 78% of the patients, with significant reduction in psoriasis symptoms. However, they also noted that thioguanine can cause myelosuppression, a condition where the bone marrow doesn't produce enough blood cells. This side effect is manageable with careful monitoring.

Thioguanine: A Potential Solution for Refractory Psoriasis

This study highlights the potential of thioguanine as a valuable treatment option for patients with severe, recalcitrant psoriasis. The positive outcomes observed, like an oasis in a desert, offer hope for individuals struggling with this chronic condition.

A Note of Caution: Monitoring Side Effects

The researchers emphasize the importance of carefully monitoring patients for myelosuppression while on thioguanine treatment. This is similar to a camel navigating a treacherous desert landscape, requiring vigilance to avoid potential dangers.

Dr.Camel's Conclusion

Thioguanine presents a potential treatment option for refractory psoriasis, offering a beacon of hope for patients who have exhausted other treatment options. However, the potential side effects require careful monitoring, emphasizing the importance of a collaborative approach between patients and their healthcare providers.

Date :
  1. Date Completed 2001-02-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11148479

DOI: Digital Object Identifier

10.1067/mjd.2001.109296

Related Literature

Article Analysis
・Side Effects of thioguanine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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