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Effects of long-term treatment with the anti-androgen bicalutamide on human testis: an ultrastructural and morphometric study.

Author: CardilloM R, D'EramoG, Di SilverioF, GradiniR, MorganteE, PerroneG A, PetrangeliE, RealacciM, RussoM, SaleP

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Overview

Long-term treatment with bicalutamide 50 mg daily has minimal impact on testicular ultrastructure and sperm maturation while effectively controlling androgen-dependent prostatic tumors.
Paper Details　
Original Abstract of the Article :
AIMS: To assess the effects of more than 4 years' treatment with the anti-androgen bicalutamide on human testis by clinical, ultrastructural and morphometric analysis. METHODS AND RESULTS: Two patients (aged 74 and 69 years) with prostate cancer were treated for more than 4 years with bicalutamide ...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2559.2001.01077.x

データ提供：米国国立医学図書館（NLM）

Bicalutamide and the Testis: A Desert of Hormonal Balance

This research examines the effects of long-term treatment with bicalutamide, an anti-androgen medication used to treat prostate cancer, on the human testis. The study assessed the impact of bicalutamide on testicular morphology and function, using clinical data, ultrastructural analysis, and morphometry.

Navigating the Desert: Bicalutamide's Effects on the Testis

The study found that long-term bicalutamide treatment had minimal impact on testicular ultrastructure and sperm maturation, suggesting that bicalutamide may be a relatively safe option for treating prostate cancer. However, the study also noted an increase in peritubular connective tissue in the testes, which may be a consequence of the age of the patients.

A Desert Oasis of Understanding: Bicalutamide and Prostate Cancer Treatment

The study provides valuable insights into the potential effects of bicalutamide on the testis, suggesting that it may be a well-tolerated treatment option for prostate cancer. However, further research is needed to confirm these findings and to explore the long-term impact of bicalutamide on testicular function.

Dr.Camel's Conclusion

This research reminds us that even in the desert of hormonal balance, carefully chosen medications can offer effective treatments. Understanding the specific effects of bicalutamide on the testis is crucial for making informed decisions about prostate cancer treatment and ensuring optimal patient outcomes.

Date :
  1. Date Completed 2001-06-28
  2. Date Revised 2019-08-22
Further Info :

Pubmed ID

11260298

DOI: Digital Object Identifier

10.1046/j.1365-2559.2001.01077.x

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in preparation
Languages

English

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