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Morphine responses in humans: a retrospective analysis of sex differences.

Author: ZacnyJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

There is increasing evidence that sex modulates the effects of opioid analgesics in nonhumans, but few studies have examined this issue in humans. Females reported higher ratings of 'coasting (spaced out),' 'heavy or sluggish feeling' and 'dry mouth.' No differences in degree of psychomotor impairment or physiological effects (miosis and respiration rate) of morphine emerged between males and females.
Paper Details　
Original Abstract of the Article :
There is increasing evidence that sex modulates the effects of opioid analgesics in nonhumans, but few studies have examined this issue in humans. Over the past seven years we have conducted several studies in which the subjective, psychomotor, and physiological effects of intravenous morphine were ...See full text at original site
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引用元：
https://doi.org/10.1016/s0376-8716(00)00186-1

データ提供：米国国立医学図書館（NLM）

Morphine Responses in Humans: A Desert of Sex Differences

The desert of pain management research is vast and complex, and the effects of opioid analgesics, like morphine, are a constant source of exploration. This study investigated sex differences in the effects of morphine, seeking to understand how this powerful drug affects men and women differently. It's like exploring two different oases, each with its unique flora and fauna, reflecting the subtle yet significant variations in response to the same environmental conditions.

The researchers conducted a retrospective analysis of six studies, comparing the subjective, psychomotor, and physiological effects of intravenous morphine in 57 males and 27 females. They found some notable differences in the subjective effects of morphine, with females reporting higher levels of certain side effects. This is like finding two different types of camels, one more sensitive to the desert heat, while the other tolerates the arid climate better.

Different Responses to Morphine

The study results suggest that there are sex-related differences in the way humans respond to morphine, with females experiencing more pronounced subjective effects. This discovery is like finding two different pathways through the desert, each leading to the same destination but offering different experiences along the way.

Tailoring Treatments for Individual Needs

These findings highlight the importance of considering individual differences, particularly sex, when administering opioid analgesics. This is like recognizing that different travelers may require different types of camels for a successful journey through the desert, with some needing more resilient camels to withstand the harsh conditions, while others may prefer faster, more agile companions.

Dr.Camel's Conclusion

This study illuminates a previously overlooked aspect of opioid research, highlighting the importance of considering sex differences in responses to morphine. It's like discovering a hidden oasis in the desert of pain management, where recognizing individual needs can lead to more effective and personalized treatments.

Date :
  1. Date Completed 2001-08-23
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

11297828

DOI: Digital Object Identifier

10.1016/s0376-8716(00)00186-1

Related Literature

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・Effects of morphine
SNS
PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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