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Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity.
Author: AokiI, FujikawaT, HasegawaT, HiroseH, KimuraT, MaseT, MitsuyaM, NishikibeM, NoguchiK, NumazawaT, OhtakeN, SasakiK, SatoA
Original Abstract of the Article :
We evaluated the pharmacological profiles of (2R)-N-[1-(6- aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide(compound A), which is a novel muscarinic receptor antagonist with M(2)-sparing antagonistic activity. Compound A inhibited [(3)H]NMS binding...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11303071
データ提供:米国国立医学図書館(NLM)
(2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: A Novel Muscarinic Antagonist
The field of [pharmacology] involves the intricate study of drug interactions with receptors in the body. This research delves into the pharmacological properties of a novel muscarinic receptor antagonist, a medication that blocks the action of a neurotransmitter called acetylcholine.
M(2)-Sparing Antagonistic Activity: A Targeted Approach
The research highlights the unique M(2)-sparing antagonistic activity of the compound, meaning it selectively inhibits the activity of specific muscarinic receptors. This targeted approach could potentially minimize side effects associated with non-selective muscarinic antagonists. It's like a camel choosing a specific path through a desert, avoiding treacherous areas while accessing the desired destination.
Potential for Therapeutic Applications: A Promising Path
The study's findings suggest that this compound may have therapeutic potential in conditions like asthma and bladder dysfunction. Further research is necessary to explore its safety and efficacy in clinical settings. It's like a camel discovering a new route through the desert, offering hope for a more efficient and effective journey.
Dr.Camel's Conclusion
This study offers a promising glimpse into the potential of novel muscarinic antagonists for treating various conditions. It's like a camel encountering a hidden spring in the desert, offering a source of hope for a more comfortable and manageable life. As research progresses, we can anticipate the development of more targeted and effective therapies for a range of medical needs.
Date :
- Date Completed 2001-05-21
- Date Revised 2014-11-20
Related Literature
English
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