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Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell lines.

Author: BurgaudJ L, Del SoldatoP, LavagnaC, RampalP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Nitrosulindac, a nitric oxide-releasing derivative of sulindac, exhibits stronger anti-cancer effects on colon adenocarcinoma cells compared to its parent compound. It achieves this through a cytostatic mechanism rather than the classical apoptosis pathway, potentially making it a superior option for colon cancer treatment.
Paper Details　
Original Abstract of the Article :
Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the incidence of colon cancer, but their use is limited by toxicity in the gastrointestinal tract. The coupling of a nitric oxide-releasing moiety to NSAIDs strongly reduces these side effects. We demonstrated that the NO-releasing sulindac (nitro...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11396974

データ提供：米国国立医学図書館（NLM）

Nitrosulindac: A New Weapon in the Desert of Colon Cancer

The desert of colon cancer is a formidable foe, demanding innovative approaches to treatment. This research explores the potential of nitrosulindac, a novel nitric oxide-releasing derivative of the anti-inflammatory drug sulindac, as a treatment for colon adenocarcinoma. The authors investigated the antiproliferative effects of nitrosulindac on human colon cancer cell lines, seeking to identify its potential as a promising anticancer agent. Their findings provide evidence for the effectiveness of nitrosulindac in inhibiting colon cancer cell growth, suggesting a potential breakthrough in colon cancer treatment.

A New Oasis in the Desert: Nitrosulindac and Colon Cancer

This research offers a glimmer of hope in the desert of colon cancer treatment. The authors demonstrate the effectiveness of nitrosulindac in inhibiting colon cancer cell growth, highlighting its potential as a promising therapeutic agent. This study paves the way for further research into the use of nitrosulindac, offering a potential weapon in the fight against this devastating disease.

Navigating Towards a Cure: The Promise of Nitrosulindac

The findings of this study offer a promising new direction in colon cancer treatment. The authors' research provides compelling evidence for the effectiveness of nitrosulindac in combating colon cancer cells. This study paves the way for further research and clinical trials, offering a potential breakthrough in the fight against this challenging disease.

Dr. Camel's Conclusion

This research offers a glimmer of hope in the desert of colon cancer treatment. Nitrosulindac, like a new oasis, provides a potential solution for combating this devastating disease. This research serves as a beacon of hope, guiding us towards a brighter future for those battling colon cancer.
Date :
  1. Date Completed 2001-08-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11396974

DOI: Digital Object Identifier

S0006-291X(01)95057-0

Related Literature

Article Analysis
・Side Effects of sulindac
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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