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The safety of cluster immunotherapy with aluminium hydroxide-adsorbed honey bee venom extract.

Author: PuccinelliP, QuerciaO, RafanelliS, StefaniniG F

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the tolerance of aqueous cluster or rush venom immunotherapy (VIT) versus cluster depot VIT in patients sensitized to Apis mellifera venom. Aqueous cluster VIT resulted in large local reactions in 4 patients, while 4 patients in the aqueous rush VIT group experienced systemic side effects. Depot VIT was well-tolerated and showed better tolerance compared to aqueous-rush VIT.
Paper Details　
Original Abstract of the Article :
Venom immunotherapy (VIT) with aqueous extracts is considered a life-saving treatment in insect allergy, but systemic side effects are quite common, especially in patients sensitized to Apis mellifera venom. Only a few studies are available regarding depot VIT administered according to the standard ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11436967

データ提供：米国国立医学図書館（NLM）

Venom Immunotherapy: Balancing Benefits and Risks

Venom immunotherapy (VIT), a life-saving treatment for severe insect allergies, involves gradually desensitizing patients to insect venom. However, VIT can trigger systemic side effects, particularly in patients allergic to honey bee venom. This study compared the tolerability of two VIT delivery methods: aqueous cluster VIT and depot cluster VIT. The researchers aimed to determine the safety and efficacy of these approaches, evaluating the frequency and severity of local and systemic side effects.

Cluster VIT: Exploring a Safer Approach

The study found that depot cluster VIT, where venom is adsorbed to aluminum hydroxide, was well-tolerated and resulted in fewer systemic side effects compared to aqueous cluster VIT. The researchers observed a significantly lower incidence of systemic side effects in the depot cluster VIT group, suggesting that this approach may offer a safer alternative for patients with severe honey bee allergies. While both cluster VIT methods demonstrated a similar incidence of large local reactions, the depot cluster VIT group experienced significantly fewer systemic reactions.

Finding the Right Path: Navigating Venom Immunotherapy

This study underscores the importance of carefully selecting the appropriate VIT approach based on individual patient factors. The findings suggest that depot cluster VIT may offer a safer option for patients with severe honey bee allergies, reducing the risk of systemic reactions. This information empowers healthcare providers to make informed decisions about treatment strategies, ensuring patient safety and maximizing the benefits of VIT.

Dr. Camel's Conclusion

This study provides valuable insights into the safety and efficacy of different VIT delivery methods. The findings suggest that depot cluster VIT may offer a safer approach for patients with severe honey bee allergies. Just as a camel navigates the desert with caution, healthcare professionals must carefully choose the right VIT approach to ensure patient safety and maximize treatment effectiveness.

Date :
  1. Date Completed 2001-12-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11436967

DOI: Digital Object Identifier

11436967

Related Literature

Article Analysis
・Side Effects of aluminum hydroxide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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