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The teratogenic effects of 6-mercaptopurine on chick embryos in ovo.

Author: GrubbR B, MontiegelE C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Injected 6-MP into fertilized chicken eggs resulted in gross morphological abnormalities in embryos, particularly in limbs, beak, and eyes. Treatment at 70 hours of incubation resulted in more severe abnormalities than at 96 hours.
Paper Details　
Original Abstract of the Article :
Fertilized eggs of single-combed White Leghorn hens were each injected through a shell window directly beneath the embryo at 70 or 96 h of incubation with 2 mg of the sodium salt of 6-MP dissolved in 0.1 M phosphate buffer, and at 11 days of incubation the embryos were examined for gross morphologic...See full text at original site
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引用元：
https://doi.org/10.1002/tera.1420110206

データ提供：米国国立医学図書館（NLM）

The Teratogenic Effects of 6-Mercaptopurine on Chick Embryos: A Study of Developmental Toxicity

This study investigates the teratogenic effects of 6-mercaptopurine (6-MP), a drug commonly used in cancer treatment, on chick embryos. The researchers injected 6-MP into fertilized chicken eggs at different stages of development, observing the embryos for morphological abnormalities. They found that 6-MP caused various malformations and growth retardation in the embryos, particularly affecting the limbs, beak, and eyes. The study highlights the potential developmental toxicity of 6-MP, emphasizing the importance of understanding its effects during pregnancy.

A Warning Sign: The Potential Risks of 6-Mercaptopurine During Pregnancy

This study serves as a reminder of the potential risks associated with 6-MP during pregnancy. The findings underscore the importance of careful consideration and monitoring when using this drug in pregnant women. It's like a desert mirage, a seemingly harmless oasis that can lead to unexpected dangers.

Navigating Pregnancy with Caution: Understanding Drug Effects

This research emphasizes the importance of understanding the potential effects of medications during pregnancy. It highlights the need for careful consideration and appropriate monitoring to minimize risks to the developing fetus. It's like carefully navigating a desert landscape, understanding the potential dangers and choosing safe pathways.

Dr. Camel's Conclusion

This study provides valuable insights into the potential teratogenic effects of 6-MP. It underscores the importance of carefully considering the risks and benefits of this drug during pregnancy. It's a reminder that the delicate journey of development requires attentive care and a thoughtful approach to medication use.

Date :
  1. Date Completed 1975-10-30
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

1154283

DOI: Digital Object Identifier

10.1002/tera.1420110206

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Languages

English

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