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Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.

Author: AsgariK, CornblattB S, De MarzoA M, DeWeeseT L, GageW R, KumarA, LinX, NelsonW G, PiantadosiS, PutziM J, YuX

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effects of procainamide, a nonnucleoside inhibitor of DNA methyltransferases, on GSTP1 CpG island hypermethylation and expression in prostate cancer cells. Procainamide reversed hypermethylation and restored GSTP1 expression in vitro and in vivo, suggesting its potential as a therapeutic agent for prostate cancer.
Paper Details　
Original Abstract of the Article :
Among the many somatic genome alterations present in cancer cells, changes in DNA methylation may represent reversible "epigenetic" lesions, rather than irreversible "genetic" alterations. Cancer cell DNA is typically characterized by increases in the methylation of CpG dinucleotides clustered into ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11751372

データ提供：米国国立医学図書館（NLM）

Reversing Cancer Cell Silencing: A Camel's Journey Through Epigenetics

Cancer cells often exhibit abnormal epigenetic modifications, including changes in DNA methylation, which can lead to the silencing of genes that normally protect against cancer. This study investigates the potential of procainamide, a nonnucleoside inhibitor of DNA methyltransferases, to reverse the silencing of the GSTP1 gene in human prostate cancer cells.

Procainamide Reverses GSTP1 Silencing

The study found that procainamide effectively reversed GSTP1 CpG island hypermethylation and reactivated GSTP1 expression in human prostate cancer cells. This suggests that procainamide could be a potential therapeutic agent for treating prostate cancer, potentially reversing the epigenetic silencing of tumor suppressor genes and restoring normal cellular function. This discovery is a significant step in the journey towards finding new and effective treatments for cancer.

Exploring Epigenetic Therapies

This research highlights the potential of epigenetic therapies for treating cancer. Just as a camel adapts to the harsh desert environment, cancer cells undergo epigenetic changes to survive and proliferate. By targeting these epigenetic modifications, researchers are developing novel therapeutic strategies that can potentially reverse the silencing of tumor suppressor genes and restore normal cell function. This research offers a promising glimpse into the future of cancer treatment, where therapies are tailored to the unique epigenetic landscape of each tumor.

Dr. Camel's Conclusion

This study demonstrates the potential of procainamide to reverse the epigenetic silencing of tumor suppressor genes, offering a new avenue for treating prostate cancer. The findings underscore the importance of understanding and targeting epigenetic modifications in cancer, paving the way for more personalized and effective therapies. As we continue to explore the mysteries of epigenetics, we're gaining valuable insights into the complexities of cancer and discovering new strategies to combat this devastating disease.

Date :
  1. Date Completed 2002-01-10
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

11751372

DOI: Digital Object Identifier

11751372

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SNS
PICO Info
in preparation
Languages

English

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